34 completed, 6 unknown, 4 terminated, 2 withdrawn. 49 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 49 | Completed 34, Unknown 6, Terminated 4, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1, Recruiting 1 |
Follow Hypoglycemia: new trials by email Literature Review of Hypoglycemia trials Research Report on Hypoglycemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-Prandial Carbohydrate Metabolism in Individuals With and Without Post-Bariatric Surgery Hypoglycemia (PBH) Glucagon for Injection (Fresenius Kabi USA), [6,6-2H2] glucose, [13C9, 15N1]-glucagon - Hypoglycemia, Hypoglycemia, Reactive | Phase 4 | Recruiting | Joslin Diabetes Center | 40 | 2026-01-27 | 2026-09-14 |
| Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration? Dapagliflozin (DAPA), Pioglitazone 45 mg, Placebo - Type 1 Diabetes | Phase 4 | Not yet recruiting | Dasman Diabetes Institute | 60 | 2025-09-15 | 2025-08-29 |
| Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. Metformin, Dulaglutide, Semaglutide 1.0 mg - Diabetes Mellitus Type 2 | Phase 4 | Completed | Fundación para la Investigación del Hospital Clínico de Valencia | 92 | 2025-05-26 | 2026-09-04 |
| Glucagon Dose-Response in Patients With Post-Bariatric Hypoglycemia Glucagon for Injection (Fresenius Kabi USA) - Hypoglycemia, Hypoglycemia, Reactive | Phase 4 | Active not recruiting | Joslin Diabetes Center | 28 | 2024-11-26 | 2026-02-06 |
| Investigating the Impact of the SGLT2 Inhibitor Empagliflozin on Postprandial Hypoglycaemia After Gastric Bypass Empagliflozin 25 MG, Placebo - Dumping Syndrome, Hypoglycemia, Reactive | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 22 | 2021-12-01 | 2023-03-14 |
| Dual-hormone Closed-loop Glucose Control in Type 1 Diabetes Glucagon, Closed-loop system - Type 1 Diabetes, Hypoglycemia | Phase 4 | Completed | Steno Diabetes Center Copenhagen | 13 | 2019-07-16 | 2022-08-18 |
| Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) Naloxone, Diazoxide, Placebo (for Naloxone) - Diabetes Mellitus, Type 1, Hypoglycemia | Phase 4 | Terminated | Albert Einstein College of Medicine | 4 | 2019-01-08 | 2025-09-11 |
| Pasireotide in the Treatment of Hypoglycemia Following Gastric Bypass Surgery Pasireotide 0.3 MG/ML, Meal tolerance test (MTT) - Hypoglycemia, Reactive | Phase 4 | Unknown | Zealand University Hospital | 5 | 2018-06-01 | 2018-07-05 |
| Effect of Ciprofloxacin Versus Levofloxacin on QTc-interval and Dysglycemia Ciprofloxacin 400 MG/200 ML Intravenous Solution, Levofloxacin 750 MG - QTc Prolongation, Hyperglycemia, Hypoglycemia | Phase 4 | Completed | Beni-Suef University | 200 | 2018-06-01 | 2020-07-02 |
| Ramadan Fasting in Patients With Corticotrope Deficiency Treated Either by Hydrocortisone or by Prednisolone Hydrocortisone, Prednisolone - Corticotropin Deficiency, Fasting | Phase 4 | Completed | University Tunis El Manar | 53 | 2018-05-17 | 2019-04-29 |
| Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia NPH Insulin, glargine, Insulin Aspart - Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes | Phase 4 | Terminated | Northwestern University | 3 | 2018-03-27 | 2020-09-11 |
| Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study-STAT Study Technosphere insulin - Diabetes Mellitus, Type 1 | Phase 4 | Completed | University of Colorado, Denver | 60 | 2017-09-30 | 2022-02-22 |
| Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan Metformin and Glimepiride (Low Dosage), Metformin and Vildagliptin (Low Dosage), Metformin and Insulin Glargine U100 (Low Dosage) - Diabetes Mellitus, Type 2 | Phase 4 | Completed | University of Jordan | 687 | 2017-02-14 | 2020-02-11 |
| The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes Alcohol, Placebo - Hypoglycemia, Diabetes Mellitus, Type 1 | Phase 4 | Completed | Hvidovre University Hospital | 12 | 2016-08-01 | 2017-07-24 |
| Pasireotide Treatment for Neuroendocrine Tumor Pasireotide, Diazoxide - Gastro-enteropancreatic Neuroendocrine Tumor | Phase 4 | Withdrawn | University of Maryland, Baltimore | 2016-04-01 | 2022-03-04 | |
| Comparison of 2 Hyperglycemia-correction Scales in Hospitalized Patients Insulin, insulin - Diabete Type 2, Hyperglycemia | Phase 4 | Completed | Hospital Universitario Clinica San Rafael | 116 | 2016-01-01 | 2023-03-03 |
| Treatment of Hypoglycemia Following Gastric Bypass Surgery Glucobay (acarbose), Januvia (sitagliptin), Verapamil HEXAL (verapamil) - Hypoglycemia, Obesity | Phase 4 | Completed | Zealand University Hospital | 11 | 2015-10-01 | 2018-03-07 |
| Glucagon Efficiency After High and Low Carbohydrate Diet High carbohydrate intake, Low carbohydrate intake - Type 1 Diabetes, Hypoglycemia | Phase 4 | Completed | Hvidovre University Hospital | 10 | 2015-10-01 | 2016-08-16 |
| Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes Insulin glargine, Insulin aspart, Supplemental insulin aspart - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Emory University | 226 | 2015-10-01 | 2023-09-28 |
| Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Insulin, Aspart - Gestational Diabetes, Hypoglycemia, Neonatal | Phase 4 | Unknown | Tampere University Hospital | 50 | 2015-09-01 | 2019-10-23 |
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Diabetes Mellitus, Type 1 (16) · Diabetes Mellitus (12) · Diabetes Mellitus, Type 2 (11) · Hyperglycemia (11) · Insulin Resistance (5) · Fasting (3) · Adrenocorticotropic hormone deficiency (1) · Autoimmune Diseases (1) · Brain Injuries, Traumatic (1) · Congenital Hyperinsulinism (1) · Critical Illness (1) · Diabetes, Gestational (1) · Diabetic Ketoacidosis (1) · Dumping Syndrome (1)
Nutritional and Metabolic Diseases (49) · Glucose Metabolism Disorders (48) · Metabolic Diseases (48) · Endocrine System Diseases (31) · Diabetes Mellitus (20) · Immune System Diseases (16) · Autoimmune Diseases (15) · Behavior (6) · Hyperinsulinism (6) · Pathological Conditions, Signs and Symptoms (6) · Feeding Behavior (4) · Pathologic Processes (4) · Acid-Base Imbalance (2) · Acidosis (2) · Body Weight (2)
Insulin Glargine (8) · Insulin Aspart (6) · Vildagliptin (6) · Insulin (4) · Metformin (4) · Sitagliptin Phosphate (4) · Diazoxide (3) · Glucagon (3) · Insulin Detemir (3) · pasireotide (3) · Glucose (2) · Injections (2) · Isophane Insulin, Human (2) · Liraglutide (2) · Pioglitazone (2)
Joslin Diabetes Center (3) · Emory University (2) · Hvidovre University Hospital (2) · Lund University (2) · Northwestern University (2) · Novartis Pharmaceuticals (2) · Steno Diabetes Center Copenhagen (2) · Tampere University Hospital (2) · Zealand University Hospital (2) · Albert Einstein College of Medicine (1) · Bassett Healthcare (1) · Baylor College of Medicine (1) · Beni-Suef University (1) · Brigham and Women's Hospital (1) · Buckinghamshire Healthcare NHS Trust (1)
United States (11) · Denmark (9) · United Kingdom (6) · Egypt (2) · France (2) · Germany (2) · Italy (2) · Jordan (2) · Kuwait (2) · Saudi Arabia (2) · Spain (2) · Sweden (2) · Tunisia (2) · Turkey (Türkiye) (2) · Australia (1)
Ahmed A Elberry, professor (1) · Ajenthen G Ranjan, MD, PhD (1) · Ajenthen Ranjan, MD (1) · Ananda Basu, MD (1) · Andreas Fritsche, MD (1) · Ayman A. Zayed, MD (1) · Caroline C Gormsen, M.D. (1) · Colin McArthur, MBBS (1) · Dalit Modan, M.D. (1) · Dario Giugliano, MD,PhD (1) · Deborah Cook, MBBS (1)
PMID 37526194, PMID 11889147, PMID 15793249, PMID 17513708, PMID 19158048, PMID 19190104, PMID 19318384, PMID 19719706, PMID 19885233, PMID 21228246, PMID 21387555, PMID 21697252, PMID 22223765, PMID 22727048, PMID 22784834, PMID 22855332, PMID 22992074, PMID 22996038, PMID 23435159, PMID 24794703, PMID 24920915, PMID 25838513, PMID 26474657, PMID 26537183, PMID 26656289, PMID 27068361, PMID 27326862, PMID 27797928, PMID 27995731, PMID 30207748, PMID 30679302, PMID 31337371, PMID 31907828, PMID 34305809, PMID 35467938, PMID 35675498, PMID 36123073, PMID 37093196, PMID 37435938, PMID 37671755, PMID 37853343, PMID 8422838
R01DK137518 (2), 2005 (1), 2019 (1), 2025 (1), K24HL103845 (1), R01DK079974 (1), R01HL109634 (1), UL1TR001102 (1)