27 completed, 3 terminated, 2 withdrawn, 1 active not recruiting. 14 Phase 4, 7 Not applicable, 6 Phase 3, 5 Phase 2, 3 Phase 1.
Follow this drug Literature Review of Isophane Insulin, Human trials Research Report on Isophane Insulin, Human
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes Insulin Isophane Human, NPH, Pre-emptive Algorithm, Triamcinolone Acetonide Knee Injection - Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus | Phase 1 / Phase 2 | Active not recruiting | Shifa International Hospital | 125 | 2026-08-10 | 2026-09-15 |
| Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin premix insulin human isophane suspension and insulin human, Humulin N plus Humulin R - Type 1 Diabetes | Phase 4 | Completed | Université NAZI BONI | 22 | 2023-06-15 | 2024-12-12 |
| Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia NPH Insulin, glargine, Insulin Aspart - Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes | Phase 4 | Terminated | Northwestern University | 3 | 2018-03-27 | 2020-09-11 |
| Comparative Study of Rinsulin® NPH, Suspension for Subcutaneous Administration, 100 IU/ml (GEROPHARM LLC, Russia) and Humulin® NPH, Suspension for Subcutaneous Administration, 100 IU/ml (Lilly France, France) Using the Euglycemic Hyperinsulinemic Clamp Method Rinsulin NPH, Humulin NPH - Pharmacokinetics, Bioequivalence | Not applicable | Completed | Geropharm | 52 | 2017-10-23 | 2020-08-06 |
| Pharmacokinetic (PK) Bioequivalence and Pharmacodynamics (PD) of Julphar Insulin N and Huminsulin® Basal Julphar Insulin N (human isophane insulin), Huminsulin® Basal (NPH, human isophane insulin) - Diabetes Mellitus | Phase 1 | Completed | Julphar Gulf Pharmaceutical Industries | 85 | 2016-11-16 | 2020-07-02 |
| Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus Metformin, Insulin - Gestational Diabetes Mellitus in Pregnancy | Phase 3 | Completed | Services Institute of Medical Sciences, Pakistan | 278 | 2016-02-01 | 2017-10-27 |
| A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulin in Patients Already Using Basal Insulin insulin glargine (U300), insulin glargine (U100), NPH insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 609 | 2015-12-21 | 2022-04-25 |
| A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulins in Insulin Naïve Patients Initiating Insulin insulin glargine (U300), insulin glargine (U100), NPH insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 705 | 2015-11-05 | 2022-04-25 |
| The Inova Type 2 Diabetes Mellitus Study Glargine, NPH - Diabetes, Type 2 | Not applicable | Withdrawn | Inova Health Care Services | 2015-04-01 | 2016-08-05 | |
| Glucose Control for Glucocorticoid Induced Hyperglycemia During Chemotherapy Sliding scale insulin, Intermediate acting insulin, Dietary advice - Hyperglycemia Steroid-induced | Phase 4 | Completed | Slotervaart Hospital | 26 | 2014-05-01 | 2016-01-07 |
| Glargine Versus NPH in Patients With Chronic Kidney Disease Glargine insulin, NPH insulin - Type 2 Diabetes Mellitus, Chronic Kidney Disease | Phase 4 | Completed | University of Sao Paulo General Hospital | 34 | 2013-12-01 | 2017-12-20 |
| Comparison of Insulin Therapy in Treating Post-Transplant Diabetes Insulin, Isophane, insulin glargine - Diabetes Mellitus | Phase 4 | Terminated | Inova Health Care Services | 2 | 2013-11-27 | 2022-07-26 |
| Comparison Study of Insulin Glargine and NPH Insulin Switching to NPH insulin, Continuation of insulin glargine - Diabetes | Phase 4 | Withdrawn | Providence Health & Services | 2013-04-01 | 2020-03-10 | |
| Comparator Trial Using Insulin Glulisine vs. Insulin Lispro for Treatment of Gestational Diabetes NPH, Insulin LISPRO, Insulin glulisine - Diabetes During Pregnancy | Phase 2 | Completed | Sansum Diabetes Research Institute | 17 | 2013-04-01 | 2018-04-18 |
| Insulin Therapy for the Prevention of New Onset Diabetes After Transplantation Prospective Study in Non-Diabetic De Novo Kidney Transplant Recipients Human insulin isophane, Humulin N (Eli Lilly), Standard of care, Insulin lispro, Humalog (Eli Lilly) in insulin pump - Hyperglycemia | Phase 3 | Completed | Medical University of Vienna | 263 | 2012-11-21 | 2019-02-19 |
| Sensor-Augmented Insulin-Pump Therapy in New-onset Diabetes After Transplantation Insulin lispro, Humalog (Eli Lilly) in insulin pump, Human insulin isophane, Humulin N (Eli Lilly), Standard of care - Hyperglycemia | Phase 3 | Completed | Medical University of Vienna | 85 | 2012-08-01 | 2018-06-06 |
| Insulin Therapy for Post-transplant Glucocorticoid Induced Hyperglycemia Neutral protamine hagedorn (NPH) insulin, Regular human insulin or Insulin Aspart, Insulin glargine - Post-Transplant Glucocorticoid Induced Diabetes | Phase 4 | Terminated | Vancouver General Hospital | 5 | 2012-08-01 | 2015-12-09 |
| Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study Dietary control, Insulin - Gestational Diabetes | Not applicable | Unknown | First Affiliated Hospital, Sun Yat-Sen University | 3 | 2012-06-01 | 2014-03-18 |
| Effect of NPH Insulin, Insulin Detemir and Insulin Glargine on GH-IGF-IGFBP Axis NPH, Detemir, Glargine - Diabetes Mellitus, Type 1 | Phase 3 | Completed | University of Aarhus | 19 | 2012-02-01 | 2012-12-04 |
| Comparative Glucose Clamp Study of Wockhardt's Human Isophane Insulin With Novolin N,in Healthy Subjects Wosulin N, Novolin N - Diabetes | Phase 1 | Completed | Wockhardt | 56 | 2010-09-01 | 2012-12-27 |
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Diabetes Mellitus (13) · Diabetes Mellitus, Type 2 (11) · Insulin Resistance (9) · Diabetes Mellitus, Type 1 (5) · Hyperglycemia (4) · Diabetes, Gestational (3) · Hypoglycemia (3) · Atherosclerosis (1) · Cardiovascular Diseases (1) · Coronary Disease (1) · Hypercholesterolemia (1) · Hypertension (1) · Obesity (1) · Osteoarthritis, Knee (1) · Renal Insufficiency, Chronic (1)
Sanofi (3) · Inova Health Care Services (2) · Medical University of Vienna (2) · University of Aarhus (2) · Amsterdam UMC, location VUmc (1) · Emory University (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Geropharm (1) · Göteborg University (1) · Julphar Gulf Pharmaceutical Industries (1) · Lise Tarnow (1) · Marcus Saemann (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Northwestern University (1) · Norwegian University of Science and Technology (1)
United States (10) · Brazil (4) · Canada (3) · Denmark (3) · United Kingdom (3) · Austria (2) · France (2) · Germany (2) · Ireland (2) · Netherlands (2) · Pakistan (2) · Romania (2) · Spain (2) · Burkina Faso (1) · China (1)
Ashley Hickman, MD (1) · Breay W Paty, MD, FRCPC (1) · David Baldwin, MD (1) · David Russell-Jones, MB BS (1) · Denise Simons-Morton, MD, PhD (1) · Doug Green (1) · Elizabeth Stephens, MD (1) · Harn-Shen Chen, MD, PhD (1) · Heidi Guthrie (1) · Jens Sandahl Christiansen, M.D. (1) · Josephine Ho, MD (1) · Kent G Lundholm, MD (1) · Kristin Castorino, DO (1)
PMID 33166419, PMID 31865758, PMID 32803882, PMID 18539917, PMID 18556343, PMID 19017758, PMID 19885233, PMID 19898642, PMID 20061358, PMID 20061360, PMID 20215456, PMID 20228401, PMID 20228404, PMID 20427682, PMID 20571135, PMID 20587587, PMID 20594588, PMID 21366473, PMID 21387555, PMID 21663644, PMID 21958949, PMID 22019270, PMID 22049171, PMID 22067102, PMID 22179956, PMID 22374637, PMID 22432114, PMID 22450889, PMID 22515638, PMID 22619083, PMID 22646230, PMID 22723577, PMID 22727048, PMID 22727547, PMID 22784834, PMID 23033246, PMID 23096052, PMID 23168248, PMID 23238658, PMID 23412077, PMID 23530004, PMID 23990163, PMID 24130356, PMID 24170759, PMID 24296848, PMID 24493100, PMID 24595629, PMID 24739875, PMID 24779562, PMID 24794703
2015 (2), 2016 (1), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1), N01HC95183 (1), N01HC95184 (1)