10 completed, 5 terminated, 3 recruiting, 3 withdrawn. 8 Phase 2, 6 Phase 1, 5 Phase 4, 2 Phase 3, 1 Not applicable.
Follow Diazoxide: new trials by email Literature Review of Diazoxide trials Research Report on Diazoxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Insulin Lowering on Lipogenesis Placebo, Diazoxide Oral Suspension, 2 mg per kg per dose, Deuterated water (2H2O/D2O), 70% - Hyperinsulinemia, Insulin Resistance | Phase 1 | Recruiting | Columbia University | 25 | 2026-07-01 | 2026-07-06 |
| Diazoxide Suppression Test P&F Study Diazoxide, 3 mg/kg per dose - Insulin Resistance, Hyperinsulinemia | Phase 1 | Terminated | Columbia University | 1 | 2024-10-23 | 2026-08-07 |
| Safety and Feasibility of Hyperkalemic Cardioplegia With Diazoxide in Cardiac Surgery (CPG-DZX) Trial IV Diazoxide - Myocardial Stunning | Phase 1 | Completed | Johns Hopkins University | 30 | 2024-07-08 | 2025-07-14 |
| Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass IV Diazoxide, Placebo - Myocardial Stunning | Phase 1 | Withdrawn | Johns Hopkins University | 2023-09-01 | 2022-09-19 | |
| Glycemic Effect of Diazoxide in NAFLD Diazoxide oral suspension, 1 mg per kg per dose, Diazoxide oral suspension, 2 mg per kg per dose, Placebo - Hyperinsulinemia, Insulin Resistance | Phase 1 | Completed | Columbia University | 22 | 2023-08-01 | 2026-09-30 |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: - Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension | Recruiting | Duke University | 5000 | 2020-03-05 | 2026-08-21 | |
| The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients Diazoxide, Placebo (for diazoxide), Nicotinic acid - Diabetes Mellitus, Type 2, Glucose, High Blood | Phase 2 | Withdrawn | Albert Einstein College of Medicine | 2019-04-21 | 2023-06-05 | |
| Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) Naloxone, Diazoxide, Placebo (for Naloxone) - Diabetes Mellitus, Type 1, Hypoglycemia | Phase 4 | Terminated | Albert Einstein College of Medicine | 4 | 2019-01-08 | 2025-09-11 |
| Regulation of Endogenous Glucose Production by Central KATP Channels Diazoxide, Nicotinic acid, Placebo - Diabetes Mellitus, Glucose Metabolism Disorders | Phase 2 | Recruiting | Albert Einstein College of Medicine | 100 | 2018-08-01 | 2026-04-28 |
| Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide Diazoxide, Placebo - Diabetes Mellitus, Type 2, Glucose, High Blood | Phase 2 | Terminated | Meredith Hawkins | 37 | 2018-06-12 | 2025-05-31 |
| Pasireotide Treatment for Neuroendocrine Tumor Pasireotide, Diazoxide - Gastro-enteropancreatic Neuroendocrine Tumor | Phase 4 | Withdrawn | University of Maryland, Baltimore | 2016-04-01 | 2022-03-04 | |
| Does Enhanced Glutamate Transporter Function Produce Antidepressant Effects in People With Major Depression? Diazoxide, Placebo - Depression | Phase 1 / Phase 2 | Terminated | National Institute of Mental Health (NIMH) | 10 | 2014-01-03 | 2017-10-13 |
| Use of Diazoxide in Acute Hypoglycaemia Diazoxide, Placebo - Type 1 Diabetes | Phase 4 | Completed | University of Dundee | 12 | 2012-01-01 | 2019-10-14 |
| Diazoxide In the Management Of Hypoglycemic Neonates Diazoxide, Ora-plus - Infant, Newborn, Diseases, Pregnancy in Diabetics | Phase 2 / Phase 3 | Unknown | University of Saskatchewan | 100 | 2009-10-01 | 2009-10-14 |
| DZX Mediated Insulin Suppression in Obese Men Placebo, Diazoxide, Metformin + Diazoxide - Obesity | Phase 2 | Completed | Rijnstate Hospital | 51 | 2008-07-01 | 2014-11-06 |
| Central Mechanisms That Regulate Glucose Metabolism in Humans Diazoxide, Placebo - Type 2 Diabetes, Glucose Metabolism Disorders | Phase 4 | Terminated | Meredith Hawkins | 10 | 2006-11-02 | 2025-05-16 |
| Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy Diazoxide, Metformin - Hypothalamic Obesity | Phase 2 | Completed | The Hospital for Sick Children | 9 | 2006-05-01 | 2017-11-17 |
| Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions DIAZOXIDE - Hypothalamic-pituitary Lesions, Craniopharyngiomas | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 40 | 2006-04-01 | 2011-02-18 |
| Insulin and Polycystic Ovary Syndrome diazoxide - PCOS | Not applicable | Completed | Virginia Commonwealth University | 21 | 2005-11-01 | 2017-06-14 |
| Efficacy of Diazoxide in Type 1 Diabetes diazoxide - Diabetes Mellitus, Type 1 | Phase 4 | Completed | Grill, Valdemar, M.D. | 40 | 2005-02-01 | 2011-07-18 |
Showing 20 of 22. Sign in to see all of them.
Diabetes Mellitus (6) · Hyperinsulinism (6) · Insulin Resistance (5) · Obesity (5) · Diabetes Mellitus, Type 1 (4) · Diabetes Mellitus, Type 2 (4) · Glucose Metabolism Disorders (4) · Hypoglycemia (4) · Myocardial Stunning (2) · Non-alcoholic Fatty Liver Disease (2) · Prediabetic State (2) · Adrenal Insufficiency (1) · Arrhythmias, Cardiac (1) · Attention Deficit Disorder with Hyperactivity (1) · Bronchopulmonary Dysplasia (1)
Albert Einstein College of Medicine (3) · Columbia University (3) · Johns Hopkins University (2) · Meredith Hawkins (2) · Rijnstate Hospital (2) · Assistance Publique - Hôpitaux de Paris (1) · Duke University (1) · Grill, Valdemar, M.D. (1) · National Institute of Mental Health (NIMH) (1) · Radboud University Medical Center (1) · The Hospital for Sick Children (1) · University of Dundee (1) · University of Maryland, Baltimore (1) · University of Saskatchewan (1) · Virginia Commonwealth University (1)
United States (13) · Canada (3) · Netherlands (3) · France (1) · Norway (1) · United Kingdom (1)
Meredith Hawkins, M.D., M.S. (4) · Joshua R Cook, MD, PhD (3) · Jennifer Lawton, MD (2) · B. Bravenboer, MD, PhD (1) · Carlos A Zarate, M.D. (1) · Chi Hornik (1) · Gerard Rongen, MD, PhD (1) · Grill Valdemar, MD PhD (1) · Hans de Boer, MD PhD (1) · Jill Hamilton, MD (1) · John E. Nestler, MD (1) · Kashif M Munir, MD (1) · Koravangattu Sankaran, MD, BS, FRCPC, F.C.C.M. (1) · Marc Mol, MD, PhD (1) · Meredith Hawkins, MD, MS (1)
PMID 22056385, PMID 23051145, PMID 27603903, PMID 29618011, PMID 30202851
R01DK069861 (3), K12DK133995 (1), K23DK140614 (1), R01DK079974 (1), R01HD035629 (1)