10 completed, 2 unknown, 1 active not recruiting, 1 recruiting. 14 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 14 | Completed 10, Unknown 2, Active not recruiting 1, Recruiting 1 |
Follow Hyperhomocysteinemia: new trials by email Literature Review of Hyperhomocysteinemia trials Research Report on Hyperhomocysteinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Dietary Management and Cysteine Supplementation on Growth Parameters and Biochemical Control for Pediatric Qatari Patients Affected with Classical B6 Non-responsive Homocystinuria. Cysteine - Classical Homocystinuria | Not applicable | Unknown | Hamad Medical Corporation | 50 | 2024-12-01 | 2024-10-02 |
| Proof of Concept Creatine Supplementation for Homocystinuria Study Creatine, Dietary methionine tracer and protein intake - Homocystinuria | Not applicable | Active not recruiting | University of British Columbia | 9 | 2024-08-19 | 2026-02-12 |
| Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels. B-TMG supplementation, B-SAM supplementation, B-TMG placebo - Hyperhomocysteinemia | Not applicable | Recruiting | S.LAB (SOLOWAYS) | 111 | 2023-10-23 | 2025-06-08 |
| Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms. Vitamin B, Placebo - Hyperhomocysteinemia, Hyperlipoproteinemias | Not applicable | Completed | S.LAB (SOLOWAYS) | 54 | 2022-03-02 | 2025-03-27 |
| Evaluation of the Express Plus Range PKU express plus - Phenylketonurias, PKU | Not applicable | Completed | Vitaflo International, Ltd | 28 | 2021-06-14 | 2026-05-18 |
| Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke Methylenetetrahydrofolate reductase (MTHFR) deficiency - Hyperhomocysteinemia, Thrombotic, Cbs-Related, Ischemic Stroke | Not applicable | Completed | Istanbul Medeniyet University | 32 | 2019-10-31 | 2020-02-27 |
| Effects of Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adults With Hyperhomocysteinemia supplementation of compound nutrients, placebo control - Hyperhomocysteinemia | Not applicable | Unknown | Huilian Zhu | 100 | 2019-05-20 | 2019-05-14 |
| Effects of Oral Supplementation With Creatine on Systemic Microvascular Endothelial Function in Vegetarian Individuals monohydrate and micronized creatine, placebo - Endothelial Dysfunction, Hyperhomocysteinemia | Not applicable | Completed | National Institute of Cardiology, Laranjeiras, Brazil | 49 | 2015-01-01 | 2017-07-31 |
| Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function Verum, Placebo - Endothelial Dysfunction, Hyperhomocysteinemia | Not applicable | Completed | Dr. Loges & Co. GmbH | 25 | 2014-10-01 | 2016-05-02 |
| Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial Inactive lozenge, Methylcobalamin - Vitamin B12 Deficiency | Not applicable | Completed | University of West London | 50 | 2012-03-01 | 2014-05-20 |
| Effect of Vitamin B12 Supplementation on Glycaemic Control in Uncontrolled Hyperhomocysteinemic Type 2 Diabetic Patients METHYLCOBALAMIN 500 micrograms - Type 2 Diabetes, Vitamin B12 Deficiency | Not applicable | Completed | Smt. Kashibai Navale Medical College and General Hospital | 38 | 2010-10-01 | 2018-03-15 |
| The Effect of Folic Acid Administration in the Progression of Microalbuminuria Folic acid, Placebo - Diabetic Nephropathies, Hyperhomocysteinemia | Not applicable | Completed | Hospital Universitario Dr. Jose E. Gonzalez | 40 | 2004-01-01 | 2008-08-19 |
| Randomized Study of Folic Acid Therapy for Hyperhomocysteinemia in Patients With End Stage Renal Disease Receiving Hemodialysis cyanocobalamin, folic acid, pyridoxine - End Stage Renal Disease, Hyperhomocysteinemia | Not applicable | Completed | Georgetown University | 84 | 1999-06-01 | 2015-03-25 |
| 5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients 5-MTHF (5-methyltetrahydrofolate), folic acid - Mortality, Hyperhomocysteinemia | Not applicable | Completed | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 341 | 1998-01-01 | 2021-03-18 |
Homocystinuria (3) · Cardiovascular Diseases (2) · Vitamin B 12 Deficiency (2) · Diabetes Mellitus, Type 2 (1) · Diabetic Nephropathies (1) · Epilepsy (1) · Glutaric Acidemia I (1) · Hyperlipoproteinemias (1) · Hypertension (1) · Inflammation (1) · Ischemic Stroke (1) · Kidney Failure, Chronic (1) · Maple Syrup Urine Disease (1) · Phenylketonurias (1)
Amino Acid Metabolism, Inborn Errors (14) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (14) · Genetic Diseases, Inborn (14) · Metabolic Diseases (14) · Metabolism, Inborn Errors (14) · Nutritional and Metabolic Diseases (14) · Avitaminosis (11) · Deficiency Diseases (11) · Malabsorption Syndromes (11) · Malnutrition (11) · Nutrition Disorders (11) · Vitamin B Deficiency (11) · Brain Diseases (4) · Central Nervous System Diseases (4) · Nervous System Diseases (4)
Folic Acid (4) · Vitamin B 12 (3) · 5-methyltetrahydrofolate (1) · Betaine (1) · Creatine (1) · Cysteine (1) · Methylenetetrahydrofolate Reductase (NADPH2) (1) · Pyridoxine (1) · calcium D-pantothenate, L-cysteine drug combination (1) · mecobalamin (1)
S.LAB (SOLOWAYS) (2) · Dr. Loges & Co. GmbH (1) · Georgetown University (1) · Hamad Medical Corporation (1) · Hospital Universitario Dr. Jose E. Gonzalez (1) · Huilian Zhu (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Istanbul Medeniyet University (1) · National Institute of Cardiology, Laranjeiras, Brazil (1) · Smt. Kashibai Navale Medical College and General Hospital (1) · University of British Columbia (1) · University of West London (1) · Vitaflo International, Ltd (1)
Russia (2) · United Kingdom (2) · Brazil (1) · Canada (1) · China (1) · Germany (1) · India (1) · Italy (1) · Mexico (1) · Qatar (1) · Turkey (Türkiye) (1) · United States (1)
Amalia A Tsiami, PhD (1) · Anita MacDonald (1) · Birgit Goyvaerts, Dr. (1) · Christopher S. Wilcox (1) · David C Chappell, PhD (1) · Eduardo Tibirica, MD, PhD (1) · Fernando J Lavalle, MD (1) · Huilian Zhu, professor (1) · Rajavel Elango, PhD (1) · Sergio Stefoni, Professor (1)