57 completed, 11 unknown, 3 not yet recruiting, 2 active not recruiting. 34 Not applicable, 5 Phase 4, 4 Phase 2, 2 Phase 3, 1 Early Phase 1.
Follow Vitamin B 12 Deficiency: new trials by email Literature Review of Vitamin B 12 Deficiency trials Research Report on Vitamin B 12 Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Versus Intravenous Vitamin B12 Replacement in Hemodialysis Patients Mecobalamin IV Injection, Mecobalamin Tablets - Vitamin B12 Deficiency, Renal Failure , Chronic | Not applicable | Completed | Jinnah Hospital | 60 | 2026-02-22 | 2026-08-24 |
| Effectiveness of a Modified Cost-Effective Dietary Plan in Promoting Weight Loss and Preservation of Lean Body Mass in Patients After Bariatric Surgery Low-Cost Post-Bariatric Diet, Standard High-cost Post-Bariatric Diet - Obesity, Bariatric Surgery | Not applicable | Not yet recruiting | Khyber Teaching Hospital | 122 | 2025-10-01 | 2025-08-08 |
| THE B-BABIES STUDY: An Observational Study of Group B Vitamins in Preterm Infants Vitamin B-12 Deficiency | Not yet recruiting | Norfolk and Norwich University Hospitals NHS Foundation Trust | 40 | 2025-09-01 | 2025-09-09 | |
| Oral Sucrosomial® Vitamin B12 in the Management of B12 Deficiency Among Metformin-Treated Type 2 Diabetes Patients Sucrosomial® Vitamin B12, Placebo (Oral) - Vitamin B 12 Deficiency, Type 2 Diabetes Mellitus (T2DM) | Not applicable | Completed | Liaquat University of Medical & Health Sciences | 50 | 2025-08-15 | 2025-12-10 |
| Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Neuropathic Pain Neuropathic Pain, Vitamin B 12 Deficiency | Completed | Gaziosmanpasa Research and Education Hospital | 96 | 2025-06-15 | 2025-09-30 | |
| Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Fibromyalgia: Retrospective Study Fibromyalgia (FM), Vitamin B 12 Deficiency | Completed | Gaziosmanpasa Research and Education Hospital | 104 | 2025-06-11 | 2026-01-26 | |
| A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by Mouth Vitamin B12, Vitamin B6, Folic acid, Vitamin B12 (Cyanocobalamin) - Vitamin B12 Deficiency | Phase 4 | Completed | Medice Arzneimittel Pütter GmbH & Co KG | 46 | 2025-04-16 | 2026-09-04 |
| Challenges in Achieving Adequate Dietary Status of Women Assessement of nutritional status, Dermis density and thickness, Skin elasticity - Nutritional Status, Nutrient Deficiency | Enrolling by invitation | Institute of Nutrition, Slovenia (Nutris) | 300 | 2025-01-06 | 2025-03-19 | |
| Diet Quality of Pregnant Women With a Strict Plant-based Diet Versus an Omnivorous Diet Daily nutritional intake - Vitamin B 12 Deficiency, Pregnancy | Not yet recruiting | Maastricht University Medical Center | 256 | 2025-01-01 | 2024-03-13 | |
| Neurological Recovery Following NOS-SACD Observational study with no interventions - Nitrous Oxide Abuse, Subacute Combined Cord Degeneration | Recruiting | Nottingham University Hospitals NHS Trust | 100 | 2024-08-19 | 2025-07-25 | |
| Vitamin B12 Status and Its Impact on Chronic Haemodialysis Patient Vitamin b12 measure - End Stage Renal Disease on Dialysis, Vitamin B 12 Deficiency | Unknown | Assiut University | 60 | 2024-07-05 | 2024-06-06 | |
| Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid Iodized salt, Experimental: Iodized salt with lower-dose folic acid fortification, Experimental: Iodized salt with higher-dose folic acid fortification - Folate Deficiency, Iodine Deficiency | Not applicable | Completed | University of California, Davis | 360 | 2024-04-25 | 2025-03-13 |
| Assessing the Efficacy of Different Carrier Systems in Oral Vitamin B12 Supplementation Vit B12 - Vitamin B 12 Deficiency | Not applicable | Completed | Liaquat University of Medical & Health Sciences | 70 | 2024-04-12 | 2024-07-18 |
| Relationship Between Vitamin D and Vitamin B12 Levels and Neuropathic Pain in Lipedema Vitamin B12 Level - Vitamin D Deficiency, B12 Deficiency Vitamin | Unknown | Fatih Sultan Mehmet Training and Research Hospital | 200 | 2024-03-01 | 2024-03-29 | |
| Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls Folic acid and vitamin B12 fortified flour, Unfortified cereal flour - Folate Deficiency, Vitamin B 12 Deficiency | Not applicable | Completed | University Ghent | 472 | 2023-12-11 | 2026-08-14 |
| Quadruple Fortified Salt Trial in India + Folic acid, + Vitamin B12, DFS - Anemia, Folate Deficiency | Not applicable | Unknown | Cornell University | 1000 | 2023-10-01 | 2024-04-01 |
| Heart Failure With Reduced Ejection Fraction: Adjuvant Therapy With Neurostimulation and Chlorella Pyrenoidosa (HD-tDCS) Chlorella pyrenoidosa, High Definition Transcranial Direct Current Stimulation - Heart Failure, Reduced Ejection Fraction, Vitamin B12 Deficiency | Not applicable | Unknown | Federal University of Paraíba | 28 | 2023-09-26 | 2024-07-30 |
| Vitamin B12 Dose Escalation Trial in Pregnancy Vitamin B12 2.6 µg, Vitamin B12 10 µg, Vitamin B12 50 µg - Vitamin B 12 Deficiency | Phase 1 | Active not recruiting | George Washington University | 50 | 2023-06-05 | 2026-02-05 |
| Hydroponic Fortification and Dietary App Effect on Nutrients Level (Harvest) Recipes consumption, Hydroponic unit - Iron Deficiency (Without Anemia), B12 Deficiency Vitamin | Not applicable | Unknown | Quadram Institute Bioscience | 52 | 2023-05-04 | 2024-07-26 |
| Effect of Household Use of Multiple Micronutrient-fortified Bouillon on Micronutrient Status Among Women and Children in Two Districts in the Northern Region of Ghana Multiple micronutrient-fortified bouillon cube, Control bouillon cube (iodine-only) - Vitamin A Deficiency, Iron-deficiency | Not applicable | Completed | University of California, Davis | 2372 | 2023-01-16 | 2024-07-12 |
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Folic Acid Deficiency (16) · Anemia (12) · Vitamin D Deficiency (8) · Anemia, Iron-Deficiency (6) · Diabetes Mellitus, Type 2 (6) · Anemia, Pernicious (5) · Iron Deficiencies (5) · Arthritis, Rheumatoid (4) · Hyperhomocysteinemia (4) · Vitamin A Deficiency (4) · Autoimmune Diseases (3) · Avitaminosis (3) · Colitis, Ulcerative (3) · Crohn Disease (3)
Nutrition Disorders (76) · Nutritional and Metabolic Diseases (76) · Vitamin B Deficiency (76) · Deficiency Diseases (75) · Malnutrition (75) · Avitaminosis (73) · Hematologic Diseases (23) · Hemic and Lymphatic Diseases (23) · Metabolic Diseases (23) · Pathological Conditions, Signs and Symptoms (15) · Nervous System Diseases (12) · Anemia (11) · Iron Metabolism Disorders (11) · Endocrine System Diseases (10) · Diabetes Mellitus (9)
Vitamin B 12 (20) · Hydroxocobalamin (5) · Folic Acid (4) · mecobalamin (3) · Blood Specimen Collection (2) · Observation (2) · Vitamin B Complex (2) · 5-methyltetrahydrofolate (1) · BaseLine dental cement (1) · Control Groups (1) · Injections, Intramuscular (1) · Pyridoxine (1) · Saline Solution (1) · Sugars (1) · Therapeutics (1)
Institute of Nutrition, Slovenia (Nutris) (4) · Haukeland University Hospital (3) · University of Aarhus (3) · University of California, Davis (3) · Cornell University (2) · Gaziosmanpasa Research and Education Hospital (2) · Liaquat University of Medical & Health Sciences (2) · Northwell Health (2) · USDA, Western Human Nutrition Research Center (2) · University Hospital, Basel, Switzerland (2) · University of British Columbia (2) · Assiut University (1) · Centre For International Health (1) · Centre Hospitalier Universitaire de Liege (1) · Charite University, Berlin, Germany (1)
United States (10) · India (6) · United Kingdom (5) · Germany (4) · Norway (4) · Pakistan (4) · Slovenia (4) · Turkey (Türkiye) (4) · Austria (3) · Denmark (3) · Nepal (3) · Canada (2) · Ethiopia (2) · Ghana (2) · Mexico (2)
Igor Pravst, PhD (2) · Julia L Finkelstein, MPH SM ScD (2) · Per Magne Ueland, M.D., Ph.D. (2) · Amalia A Tsiami, PhD (1) · Andrew McGovern, MD (1) · Anne-Mette Hvas, MD, Ph.D. (1) · Anne-Mette Hvas, MD, PhD (1) · Benno Roesch, MD (1) · Chengshun R Fang, Ph.D. (1) · Christopher Hill, PhD (1) · Cyrill Jeger, MD (1) · David C Chappell, PhD (1)
PMID 18190464, PMID 21246600, PMID 24025626, PMID 10022413, PMID 11410823, PMID 11506296, PMID 14616423, PMID 16493517, PMID 17196442, PMID 17658015, PMID 18595990, PMID 18830787, PMID 19487104, PMID 2011158, PMID 20186576, PMID 20814760, PMID 21600388, PMID 21623649, PMID 22650964, PMID 22915298, PMID 23550594, PMID 23697526, PMID 25139582, PMID 25458341, PMID 27323792, PMID 27683780, PMID 27756315, PMID 28052884, PMID 28326664, PMID 28360040, PMID 28421567, PMID 28851784, PMID 29092879, PMID 29878267, PMID 29931179, PMID 30680547, PMID 31915511, PMID 32189314, PMID 32457078, PMID 32819927, PMID 33180098, PMID 33515301, PMID 33847257, PMID 34027296, PMID 34785540, PMID 35157313, PMID 35228574, PMID 35623855, PMID 36045399, PMID 36130238
2019 (1)