23 completed, 18 unknown, 3 terminated, 1 recruiting. 29 Not applicable, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 29 | Unknown 13, Completed 12, Terminated 3, Recruiting 1 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
Follow Hypercapnic Respiratory Failure: new trials by email Literature Review of Hypercapnic Respiratory Failure trials Research Report on Hypercapnic Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Automated Oxygen Titration With the EMILY.AI Device in a Respiratory Intermediate Care Unit Emily.AI, Manual oxygen titration - Chronic Respiratory Failure, Acute Respiratory Failure | Not applicable | Recruiting | Aether Tech S.L. | 60 | 2026-01-23 | 2026-10-29 |
| Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV) - Type II Respiratory Failure, Hypercapnic Respiratory Failure | Not applicable | Completed | Benha University | 200 | 2025-04-15 | 2026-08-25 |
| Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor IscAlert sensor - Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive | Completed | The Hospital of Vestfold | 21 | 2025-01-30 | 2026-06-11 | |
| Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients Respiratory Support - Hypercapnic Respiratory Failure, COPD | Not applicable | Unknown | Aalborg University Hospital | 138 | 2024-03-31 | 2024-02-14 |
| Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure | Unknown | Yonsei University | 100 | 2023-11-01 | 2023-10-03 | |
| NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP Average Volume-Assured Pressure Support (AVAPS), Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T) - Hypercapnic Respiratory Failure | Not applicable | Unknown | Northwell Health | 100 | 2023-10-07 | 2023-10-31 |
| Novel ECCO2R Device for Hypercapnic Respiratory Failure Prismalung + treatment - Hypercapnic Respiratory Failure | Unknown | University of Zurich | 60 | 2023-06-05 | 2023-12-28 | |
| Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure High flow nasal cannula, Conventional low flow oxygenation - Hypercapnic Respiratory Failure, Acute Copd Exacerbation | Not applicable | Unknown | Hôpital de Verdun | 84 | 2022-10-01 | 2022-08-11 |
| Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation Remote monitoring of home mechanical ventilation (NIV) using SRETT, Home mechanical ventilation (NIV) without remote monitoring - Hypercapnic Respiratory Failure, Sleep Disordered Breathing | Not applicable | Completed | Guy's and St Thomas' NHS Foundation Trust | 32 | 2022-03-28 | 2024-06-18 |
| Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients Information-Motivation-Behavioral skills (IMB) model-based intervention, Control - usual care - Hypercapnic Respiratory Failure, Noninvasive Ventilation | Not applicable | Completed | The University of Hong Kong | 124 | 2021-09-16 | 2025-11-28 |
| NHF vs. COT in Hypoxemic Pandemic Viral Illness Standard oxygen, Nasal high-flow - Acute Viral Bronchitis, Hypoxemic Respiratory Failure | Not applicable | Unknown | Jens Bräunlich | 52 | 2021-01-22 | 2022-03-31 |
| Clinical Stabilization of Hypercapnia: NIPPV v HVNI High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV) - Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease | Not applicable | Completed | Vapotherm, Inc. | 68 | 2020-11-11 | 2024-08-09 |
| Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome ECCO2R - ARDS, Hypercapnic Respiratory Failure | Not applicable | Completed | University of Giessen | 20 | 2020-05-03 | 2025-03-04 |
| High-flow Air Via Nasal Cannula vs Non-invasive Continuous Positive Airway Pressure for Hypercapnic Respiratory Failure High flow nasal cannula, Continuous positive airway pressure - Hypercapnic Respiratory Failure | Not applicable | Unknown | Medical University of Vienna | 62 | 2020-01-01 | 2020-02-20 |
| Transcutaneous CO2 Measurement - From Hospital to Home Transcutaneous CO2 monitoring - Type 2 Respiratory Failure, Hypercapnic Respiratory Failure | Completed | University of Oslo | 129 | 2020-01-01 | 2024-11-19 | |
| HFNC vs NPPV After Early Extubation for Patients With COPD HFNC, NPPV - COPD, Hypercapnic Respiratory Failure | Not applicable | Unknown | Chinese PLA General Hospital | 502 | 2019-12-18 | 2020-01-23 |
| Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation AVAPS-AE mode during NIV, S/T mode during NIV - Acute Respiratory Failure, Hypercapnic Respiratory Failure | Not applicable | Terminated | University Hospital, Rouen | 14 | 2019-12-04 | 2026-04-15 |
| Ketogenic Diet for Obesity Hypoventilation Syndrome Ketogenic Diet - Obesity Hypoventilation Syndrome, Ketogenic Dieting | Not applicable | Completed | Johns Hopkins University | 24 | 2019-10-30 | 2022-07-01 |
| Mathematically Arterialised Testing of Hypercapnic Subjects Study Hypercapnic Respiratory Failure | Completed | Papworth Hospital NHS Foundation Trust | 84 | 2018-10-15 | 2022-09-28 | |
| High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure HFNC, standard - Hypercapnic Respiratory Failure | Not applicable | Unknown | University Hospital, Mahdia | 100 | 2018-07-01 | 2018-08-13 |
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Respiratory Insufficiency (45) · Pulmonary Disease, Chronic Obstructive (19) · Hypercapnia (9) · Hypoventilation (4) · Obesity Hypoventilation Syndrome (4) · Hypoxia (3) · Acidosis, Respiratory (2) · Emergencies (2) · Neuromuscular Diseases (2) · Sleep Apnea Syndromes (2) · Acidosis (1) · Apnea (1) · Dyspnea (1) · Obesity (1) · Patient Compliance (1)
Respiration Disorders (45) · Respiratory Tract Diseases (45) · Pathological Conditions, Signs and Symptoms (31) · Disease Attributes (21) · Pathologic Processes (21) · Chronic Disease (19) · Lung Diseases (19) · Lung Diseases, Obstructive (19) · Signs and Symptoms (14) · Signs and Symptoms, Respiratory (14) · Nutritional and Metabolic Diseases (6) · Dyssomnias (5) · Nervous System Diseases (5) · Nutrition Disorders (5) · Overnutrition (5)
Noninvasive Ventilation (7) · Continuous Positive Airway Pressure (2) · Clinical Protocols (1) · Diet, Ketogenic (1) · Head Protective Devices (1) · Reference Standards (1) · Respiration (1) · Snow (1) · Therapeutics (1)
Guangzhou Institute of Respiratory Disease (3) · University Hospital, Rouen (3) · Guy's and St Thomas' NHS Foundation Trust (2) · Hospital Clinic of Barcelona (2) · The First Affiliated Hospital of Guangzhou Medical University (2) · United Christian Hospital (2) · University Hospital, Montpellier (2) · University of Lausanne Hospitals (2) · Aalborg University Hospital (1) · Aether Tech S.L. (1) · Albert Einstein Healthcare Network (1) · Assistance Publique - Hôpitaux de Paris (1) · Baskent University (1) · Benha University (1) · Chinese PLA General Hospital (1)
China (7) · France (6) · Spain (4) · United States (4) · Germany (3) · Hong Kong (3) · Italy (3) · Switzerland (3) · United Kingdom (3) · Norway (2) · Turkey (Türkiye) (2) · Austria (1) · Canada (1) · Colombia (1) · Dominican Republic (1)
Mustapha Sebbane, MD, PhD (2) · Ahmed Mostafa Abdelhamid, Professor of Anesthesia (1) · Andrew Meltzer, MD, MS (1) · Anne-Marie Gabrielsen, MD, PhD (1) · Anthony Innabi, MBA, RRT-NPS (1) · Antoine Cuvelier, MD, PhD (1) · Begum Ergan (1) · Christopher W Jones, MD (1) · Chung-Ming Chu, MD (1) · Cynthia Pfeiffer, MD (1) · David Yamane, MD (1) · Doris SF Yu, PhD (1)
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