26 completed. 26 Phase 2, 4 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 26 | Completed 26 |
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 3 | Completed 3 |
Follow Hemangioma: new trials by email Literature Review of Hemangioma trials Research Report on Hemangioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Tolerability Study of QLS-101 in Adolescents With Sturge-Weber Syndrome (SWS)-Related Glaucoma Due to Elevated Episcleral Venous Pressure (EVP) QLS-101 ophthalmic solution, 2.0 % - Sturge-Weber Syndrome, Glaucoma | Phase 2 | Completed | Qlaris Bio, Inc. | 2 | 2022-11-23 | 2025-01-20 |
| The Symptomatic Cerebral Cavernous Malformation Trial of REC-994 REC-994, Placebo - Cerebral Cavernous Malformation | Phase 2 | Completed | Recursion Pharmaceuticals Inc. | 62 | 2022-03-17 | 2026-10-22 |
| A Study to Determine the Safety and Tolerability of 2 Concentrations of QLS-101 QLS-101ophthalmic solution 1%, QLS-101ophthalmic solution 2% - Sturge-Weber Syndrome (SWS), Glaucoma | Phase 2 | Completed | Qlaris Bio, Inc. | 3 | 2021-10-19 | 2025-01-20 |
| Timolol Maleate Gel for the Treatment of Infantile Hemangioma Timolol Maleate Gel+Placebo, Timolol Maleate Gel, Placebo - Infantile Hemangioma | Phase 2 / Phase 3 | Completed | Auson Pharmaceuticals Inc. | 168 | 2020-10-28 | 2024-11-07 |
| Novel Cognitive Treatment Targets for Epidiolex in Sturge- Weber Syndrome Cannabidiol - Sturge-Weber Syndrome | Phase 2 | Completed | Anne Comi, MD | 11 | 2019-10-14 | 2023-05-25 |
| Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Atorvastatin, Placebo - Cerebral Cavernous Malformation | Phase 1 / Phase 2 | Completed | University of Chicago | 80 | 2018-07-17 | 2025-08-22 |
| Treat_CCM: Propranolol in Familial Cerebral Cavernous Malformation Propranolol - Cerebral Cavernous Malformation | Phase 2 | Completed | Mario Negri Institute for Pharmacological Research | 71 | 2018-04-11 | 2022-02-25 |
| Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE) Eribulin - Angiosarcoma, Epithelioid Hemangioendothelioma | Phase 2 | Completed | Massachusetts General Hospital | 13 | 2018-01-18 | 2026-08-28 |
| Trametinib in Treating Patients With Epithelioid Hemangioendothelioma That is Metastatic, Locally Advanced, or Cannot Be Removed by Surgery Questionnaire Administration, Trametinib - Locally Advanced Epithelioid Hemangioendothelioma, Metastatic Epithelioid Hemangioendothelioma | Phase 2 | Completed | National Cancer Institute (NCI) | 44 | 2017-06-20 | 2024-11-26 |
| Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma Sirolimus, Prednisolone - Kaposiform Hemangioendothelioma, Kasabach Merritt Phenomenon | Phase 2 | Completed | West China Hospital | 30 | 2017-06-01 | 2022-04-21 |
| Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas Sunitinib 37.5 MG, Sunitinib 25 MG [Sutent], Nivolumab 100 MG/10 ML [Opdivo], Epirubicin - Soft Tissue Sarcoma, Bone Sarcoma | Phase 1 / Phase 2 | Completed | Grupo Espanol de Investigacion en Sarcomas | 197 | 2017-05-31 | 2024-08-13 |
| Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) 0.25% Timolol Maleate Gel Forming Solution, 0.5% Timolol Maleate Gel Forming Solution - Infantile Hemangioma | Phase 2 | Completed | Kanecia Obie Zimmerman | 105 | 2017-05-05 | 2024-03-12 |
| Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Sirolimus - Sturge-Weber Syndrome | Phase 2 / Phase 3 | Completed | Anne Comi, MD | 10 | 2017-01-01 | 2021-11-01 |
| Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes Durvalumab, Tremelimumab - Advanced and/or Metastatic Sarcoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 57 | 2016-08-16 | 2025-06-12 |
| Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Cannabidiol - Sturge-Weber Syndrome | Phase 1 / Phase 2 | Completed | Anne Comi, MD | 5 | 2014-12-01 | 2022-03-02 |
| Topical Timolol Gel for the Treatment of Infantile Hemangiomas timolol maleate 0.5% gel - Hemangioma | Phase 2 | Completed | Rady Children's Hospital, San Diego | 26 | 2014-05-01 | 2017-02-13 |
| Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Timolol, Placebo - Hemangioma | Phase 2 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 70 | 2014-03-01 | 2018-11-14 |
| Gemcitabine With or Without Pazopanib in Treating Patients With Refractory Soft Tissue Sarcoma Gemcitabine, Gemcitabine Hydrochloride, Laboratory Biomarker Analysis - Adult Alveolar Soft Part Sarcoma, Adult Angiosarcoma | Phase 2 | Completed | OHSU Knight Cancer Institute | 54 | 2012-03-13 | 2021-09-27 |
| Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo propranolol gel, Placebo - Infantile Hemangioma | Phase 2 | Completed | Pierre Fabre Dermatology | 82 | 2012-01-01 | 2014-10-30 |
| Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Gamma-Secretase Inhibitor RO4929097, Laboratory Biomarker Analysis, Pharmacological Study - Adult Alveolar Soft Part Sarcoma, Adult Angiosarcoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 78 | 2010-06-01 | 2018-08-15 |
Showing 20 of 26. Sign in to see all of them.
Hemangioendothelioma, Epithelioid (6) · Hemangioma, Capillary (6) · Hemangiosarcoma (5) · Sturge-Weber Syndrome (5) · Histiocytoma, Malignant Fibrous (4) · Leiomyosarcoma (4) · Sarcoma, Synovial (4) · Chondrosarcoma, Extraskeletal Myxoid (3) · Hemangioma, Cavernous, Central Nervous System (3) · Osteosarcoma (3) · Sarcoma (3) · Sarcoma, Alveolar Soft Part (3) · Chondrosarcoma (2) · Cognitive Dysfunction (2)
Neoplasms by Histologic Type (26) · Neoplasms, Vascular Tissue (26) · Neoplasms (25) · Nervous System Diseases (13) · Cardiovascular Diseases (11) · Vascular Diseases (11) · Neurocutaneous Syndromes (7) · Angiomatosis (6) · Brain Diseases (6) · Central Nervous System Diseases (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Congenital Abnormalities (5) · Hemangioendothelioma (5) · Hematologic Diseases (5)
Propranolol (3) · Cannabidiol (2) · Sirolimus (2) · Sunitinib (2) · Timolol (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Adrenal Cortex Hormones (1) · Adrenergic beta-Antagonists (1) · Atorvastatin (1) · Cisplatin (1) · Dacarbazine (1) · Doxorubicin (1) · Epirubicin (1) · Gels (1) · Gemcitabine (1)
Anne Comi, MD (3) · National Cancer Institute (NCI) (2) · Pierre Fabre Dermatology (2) · Qlaris Bio, Inc. (2) · Auson Pharmaceuticals Inc. (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Grupo Espanol de Investigacion en Sarcomas (1) · Kanecia Obie Zimmerman (1) · M.D. Anderson Cancer Center (1) · Mario Negri Institute for Pharmacological Research (1) · Massachusetts General Hospital (1) · Memorial Sloan Kettering Cancer Center (1) · Novartis Pharmaceuticals (1) · OHSU Knight Cancer Institute (1) · Rady Children's Hospital, San Diego (1)
United States (17) · Spain (4) · Canada (3) · Italy (3) · China (2) · France (2) · Poland (2) · Australia (1) · Brazil (1) · Czechia (1) · Germany (1) · Hungary (1) · Lithuania (1) · Mexico (1) · New Zealand (1)
Anne M Comi, MD (2) · Alba Rubio (1) · Anne M Comi, M.D. (1) · Antonio Casado (1) · B. Wirostko, M.D. (1) · Catherine McCuaig, M.D. (1) · Christine Labreze, MD (1) · Christopher W Ryan (1) · Claudia Valverde (1) · Cristina Mata (1) · Daniel F Hanley, MD (1) · Dov C Goldenberg, MD (1)
PMID 31401903, PMID 19419474, PMID 25693013, PMID 32398113, PMID 33203665, PMID 35030255, PMID 35443056, PMID 35934010, PMID 36403580, PMID 38419711, PMID 39356980, PMID 40120614, PMID 40570636, PMID 41117517, PMID 41608890, PMID 41836677
2017 (1), N01CM62206 (1), P30CA008748 (1), P30CA046592 (1), U01CA069856 (1), U54NS065705 (1)