5 completed, 4 terminated, 2 recruiting, 2 unknown. 4 Phase 2, 2 Early Phase 1, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Early Phase 1 | 2 | Not yet recruiting 1, Terminated 1 |
| Not applicable | 1 | Terminated 1 |
| Phase 1 | 1 | Completed 1 |
Follow Hemangioma, Cavernous, Central Nervous System: new trials by email Literature Review of Hemangioma, Cavernous, Central Nervous System trials Research Report on Hemangioma, Cavernous, Central Nervous System
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Daratumumab for Familial Cerebral Cavernous Malformations: A Single-Arm Safety and Efficacy Study Daratumumab - Cavernous Malformation, Cerebral | Early Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 10 | 2025-07-01 | 2025-06-18 |
| Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM) Hyperventilation and CO2 challenge - Cerebral Cavernous Malformation | Not applicable | Terminated | University of New Mexico | 5 | 2023-06-15 | 2025-06-11 |
| The Symptomatic Cerebral Cavernous Malformation Trial of REC-994 REC-994, Placebo - Cerebral Cavernous Malformation | Phase 2 | Completed | Recursion Pharmaceuticals Inc. | 62 | 2022-03-17 | 2026-10-22 |
| CCM Blood Biomarker Validation Study CCM Hemorrhagic Panel - Hemorrhagic Stroke, Intracerebral, Cerebral Cavernous Malformation | Terminated | Texas Tech University Health Sciences Center, El Paso | 12 | 2021-01-01 | 2023-09-01 | |
| Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations Hemangioma, Cavernous, Central Nervous System | Recruiting | Beijing Tiantan Hospital | 1200 | 2020-09-01 | 2025-07-30 | |
| Biomarkers of CASH observational - Cerebral Cavernous Malformation, Cavernous Angioma | Active not recruiting | University of Chicago | 1040 | 2020-05-22 | 2025-08-11 | |
| Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy Cavernous Malformation, Cerebral, Cavernous Angioma | Recruiting | yuanli Zhao | 200 | 2019-09-03 | 2019-09-04 | |
| CASH (Cavernous Angiomas With Symptomatic Hemorrhage) Trial Readiness CCM, Cavernoma | Completed | University of Chicago | 123 | 2018-08-20 | 2024-06-27 | |
| Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Atorvastatin, Placebo - Cerebral Cavernous Malformation | Phase 1 / Phase 2 | Completed | University of Chicago | 80 | 2018-07-17 | 2025-08-22 |
| Treat_CCM: Propranolol in Familial Cerebral Cavernous Malformation Propranolol - Cerebral Cavernous Malformation | Phase 2 | Completed | Mario Negri Institute for Pharmacological Research | 71 | 2018-04-11 | 2022-02-25 |
| Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation Propranolol, DNA and RNA Analysis - Cerebral Cavernous Malformations | Phase 2 | Terminated | St. Joseph's Hospital and Medical Center, Phoenix | 4 | 2018-01-24 | 2024-04-19 |
| Treatments and Outcomes of Untreated Cerebral Cavernous Malformations in CHina. Surgery, Observation - Cerebral Cavernous Malformations | Unknown | First Affiliated Hospital of Fujian Medical University | 2000 | 2018-01-01 | 2018-03-19 | |
| CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study Cerebral Cavernous Malformation, Intracerebral Hemorrhage | Unknown | Seoul National University Hospital | 228 | 2016-06-01 | 2022-05-12 | |
| Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins Simvastatin - Cavernous Angioma, Familial, Cerebral Cavernous Malformations | Early Phase 1 | Terminated | University of New Mexico | 12 | 2012-03-01 | 2024-03-12 |
| Modifiers of Disease Severity in Cerebral Cavernous Malformations Cavernous Angioma, Familial, Cerebral Cavernous Malformations | Completed | University of California, San Francisco | 789 | 2010-04-27 | 2026-07-27 |
Hemangioma, Cavernous (3) · Cerebral Cavernous Malformations 2 (1) · Cerebral Cavernous Malformations 3 (1) · Cerebral Hemorrhage (1) · Epilepsy (1) · Hemangioma, Capillary (1) · Hemorrhagic Stroke (1) · Seizures (1)
Brain Diseases (15) · Cardiovascular Abnormalities (15) · Cardiovascular Diseases (15) · Cavernous Sinus Syndromes (15) · Central Nervous System Diseases (15) · Central Nervous System Vascular Malformations (15) · Congenital Abnormalities (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (15) · Hemangioma (15) · Hematologic Diseases (15) · Hemic and Lymphatic Diseases (15) · Hemorrhagic Disorders (15) · Hemostatic Disorders (15) · Neoplasms (15) · Neoplasms by Histologic Type (15)
Propranolol (2) · Atorvastatin (1) · DNA (1) · Observation (1) · Simvastatin (1) · Surgical Procedures, Operative (1) · Watchful Waiting (1) · daratumumab (1)
University of Chicago (3) · Beijing Tiantan Hospital (2) · University of New Mexico (2) · First Affiliated Hospital of Fujian Medical University (1) · Mario Negri Institute for Pharmacological Research (1) · Recursion Pharmaceuticals Inc. (1) · Seoul National University Hospital (1) · St. Joseph's Hospital and Medical Center, Phoenix (1) · Texas Tech University Health Sciences Center, El Paso (1) · University of California, San Francisco (1) · yuanli Zhao (1)
United States (9) · China (4) · Italy (1) · South Korea (1)
Issam A Awad, MD (2) · Issam Awad, MD (2) · Blaine Hart, MD (1) · Daniel F Hanley, MD (1) · Daniel Hanley, MD (1) · Dezhi Kang, MD,PHD (1) · Elisabetta Dejana, Professor (1) · Helen Kim, MPH, PhD (1) · Helen Kim, PhD (1) · JeongEun Kim, MD. PhD. (1) · Joseph Zabramski, MD (1) · Jun Zhang (1) · Kelly Flemming, MD (1) · Leslie A Morrison, MD (1) · Li Ma, MD, PhD (1)
PMID 19833796, PMID 24323376, PMID 24401931, PMID 25472749, PMID 25556204, PMID 25565562, PMID 26795600, PMID 28318403, PMID 28387823, PMID 28489816, PMID 28534135, PMID 30140608, PMID 31643041, PMID 31776290, PMID 31825263, PMID 32100472, PMID 32398113, PMID 32461638, PMID 32467184, PMID 32467778, PMID 32951540, PMID 33122314, PMID 33469662, PMID 34389651, PMID 34479577, PMID 34491620, PMID 36403580, PMID 36695309, PMID 37333396, PMID 38134265, PMID 38134268, PMID 38419711, PMID 40120614, PMID 40175401, PMID 40570636, PMID 40614265, PMID 40899314, PMID 41117517, PMID 41608890
U54NS065705 (2), 2017 (1), R01NS114552 (1), U01NS104157 (1)