11 recruiting, 10 not yet recruiting, 9 completed, 3 active not recruiting. 16 Not applicable, 9 Phase 4, 5 Phase 2, 3 Phase 1, 2 Phase 3.
Follow Heart Failure With Reduced Ejection Fraction (HFrEF): new trials by email Literature Review of Heart Failure With Reduced Ejection Fraction (HFrEF) trials Research Report on Heart Failure With Reduced Ejection Fraction (HFrEF)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure AC01, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 2 | Not yet recruiting | AnaCardio AB | 400 | 2026-11-15 | 2026-09-14 |
| Implementation of an Encounter-based Patient Decision Aid for Heart Failure Medications in Heart Function Clinics: the SHARE-HF Pragmatic, Stepped-wedge Trial SHARE-HF decision aid - Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Not yet recruiting | University of British Columbia | 1350 | 2026-11-02 | 2026-06-26 |
| Yiqi Fumai Lyophilized Injection for Chronic Heart Failure Caused by Coronary Heart Disease Yiqi Fumai Lyophilized Injection(YQFM), Stable Guideline-Directed Medical Therapy - Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Not yet recruiting | China Academy of Chinese Medical Sciences | 100 | 2026-09-01 | 2026-09-09 |
| Achieving Optimal Medical Therapy Through Percutaneous Treatment of Secondary Mitral Regurgitation to Improve Outcome in Patients With HFrEF M-TEER, Standardized GDMT Up-Titration - Mitral Regurgitation Functional, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Not yet recruiting | University Medical Center Mainz | 520 | 2026-08-10 | 2026-08-11 |
| Comparing the Efficacy and Safety of Vericiguat With Standard Medical Treatment in Heart Failure Patients Vericiguat tablet, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 4 | Not yet recruiting | National Institute of Cardiovascular Diseases, Pakistan | 500 | 2026-07-15 | 2026-07-13 |
| A Trial of CRD-4730 in HFrEF CRD-4730, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 2 | Recruiting | Cardurion Pharmaceuticals, Inc. | 525 | 2026-07-15 | 2026-08-06 |
| Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction Extra-virgin olive oil - Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Recruiting | Old Dominion University | 40 | 2026-07-01 | 2026-10-16 |
| RELIEVE METAB Study cardiac MRI, Functional Testing - Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Not yet recruiting | Heinrich-Heine University, Duesseldorf | 15 | 2026-06-01 | 2026-04-29 |
| Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? Guideline-Directed Medical Therapy (GDMT) - Heart Failure, Acute Heart Failure | Phase 4 | Recruiting | IRCCS Policlinico S. Donato | 368 | 2026-03-31 | 2026-10-16 |
| Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure Telemedicine-based follow-up, Standard follow-up - Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Recruiting | Azienda Unita Sanitaria Locale di Piacenza | 80 | 2026-03-20 | 2026-05-18 |
| Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction Right Greater Splanchnic Nerve (GSN) ablation, Sham Control - Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Not yet recruiting | Axon Therapies, Inc. | 50 | 2026-03-01 | 2026-02-11 |
| Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not yet recruiting | Xinjiang Medical University | 600 | 2026-01-01 | 2026-01-21 | |
| Heart Failure Management for Patient With CIED Remotely Monitored SmartSignalHF, HF RM standard of care - Heart Failure, Heart Failure NYHA Class II | Not applicable | Recruiting | Implicity | 1132 | 2025-12-19 | 2026-03-31 |
| Vericiguat and Reverse Remodeling Indices in Heart Failure Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT) - Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure | Phase 4 | Recruiting | University Medical Centre Ljubljana | 70 | 2025-11-01 | 2026-09-29 |
| Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator Metoprolol Succinate, Carvedilol - Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death | Phase 4 | Recruiting | University of Rochester | 2000 | 2025-08-17 | 2025-09-18 |
| AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices Intervention Group (Device Group - AI-Based Remote Monitoring), Standard Clinical Follow-Up - Chronic Heart Failure, Cardiovascular Diseases | Recruiting | University of Salerno | 205 | 2025-08-01 | 2026-03-11 | |
| Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure Ramipril - Chronic Kidney Disease, Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 4 | Recruiting | Evi Liliek Wulandari | 80 | 2025-06-30 | 2025-12-10 |
| Evaluating Dashboard-Integrated Pharmacist-Led Education on Improving Sacubitril/Valsartan Adherence in Heart Failure (PharmD ASSIST HFrEF) interactive visualization dashboard (the Enhancing Sacubitril/valsartan Adherence from Initiation to Continuation [ESAIC] dashboard) - Heart Failure With Reduced Ejection Fraction (HFrEF), Sacubitril/Valsartan | Not applicable | Not yet recruiting | National Taiwan University Hospital | 200 | 2025-04-07 | 2025-04-02 |
| IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches Ferric Carboxymaltose, Ferrous Sulfate - Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 4 | Terminated | Syed Hamza Mufarrih | 42 | 2025-04-02 | 2026-07-20 |
| Metabolomic Profiling in Ischemic and Non-Ischemic Cardiomyopathy Patients With Ventricular Arrhythmias Heart Failure With Reduced Ejection Fraction (HFrEF), Ventricular Tachycardia (VT) | Completed | Muhammed Heja Geçit | 60 | 2025-03-02 | 2026-04-02 |
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Heart Failure (20) · Cardiomyopathies (4) · Cardiovascular Diseases (3) · Arrhythmias, Cardiac (2) · Iron Deficiencies (2) · Anemia, Iron-Deficiency (1) · Bundle-Branch Block (1) · Cardiomyopathy, Dilated (1) · Coronary Disease (1) · Death, Sudden, Cardiac (1) · Diabetes Mellitus, Type 2 (1) · Euthyroid Sick Syndromes (1) · Fibrosis (1) · Heart Diseases (1) · Heart Failure, Diastolic (1)
Heart Diseases (23) · Cardiovascular Diseases (22) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Cardiac Conduction System Disease (2) · Chronic Disease (2) · Disease Attributes (2) · Endocrine System Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Glucose Metabolism Disorders (2) · Iron Metabolism Disorders (2) · Kidney Diseases (2)
vericiguat (3) · dapagliflozin (2) · Angiotensin-Converting Enzyme Inhibitors (1) · Carvedilol (1) · Control Groups (1) · Dopamine (1) · Fosfomycin (1) · Iron (1) · Metoprolol (1) · Ramipril (1) · Self Care (1) · Sodium Chloride (1) · Triiodothyronine (1) · ferric carboxymaltose (1) · ferrous sulfate (1)
AstraZeneca (2) · Xinjiang Medical University (2) · AnaCardio AB (1) · Ancora Heart, Inc. (1) · Antai Medical Care Corperation Antai Tian-Sheng Memorial Hospital/ Department of Nursing/National Ta (1) · Axon Therapies, Inc. (1) · Azienda Unita Sanitaria Locale di Piacenza (1) · Beijing Anzhen Hospital (1) · Cardurion Pharmaceuticals, Inc. (1) · Cheng-Hsin General Hospital (1) · China Academy of Chinese Medical Sciences (1) · Damanhour University (1) · Evi Liliek Wulandari (1) · Federal University of Uberlandia (1) · Heinrich-Heine University, Duesseldorf (1)
United States (10) · Italy (5) · China (4) · Taiwan (3) · Brazil (2) · Czechia (2) · France (2) · Germany (2) · Greece (2) · Indonesia (2) · Japan (2) · Netherlands (2) · Poland (2) · South Korea (2) · Sweden (2)
Anne R Cappola, MD,ScM (1) · Chih-Wen Chen (1) · Ghazala Irfan, FCPS (1) · Gregor Poglajen, MD, PhD (1) · Guangyuan Song, M.D. (1) · Josef Stehlik, M.D, M.P.H. (1) · Kaveh Azizi, MD (1) · Kazutaka Aonuma, MD (1) · Klaus Witte, MD (1) · Lianxin Wang (1) · Malte Kelm, MD (1) · Marat Fudim, MD, MHS (1) · Martin B Leon, MD (1) · Megan Coylewright, MD, MPH, FSCAI, FACC (1)
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