20 completed, 9 recruiting, 4 unknown, 2 active not recruiting. 24 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 24 | Completed 12, Recruiting 9, Unknown 2, Not yet recruiting 1 |
| Phase 2 | 2 | Unknown 1, Withdrawn 1 |
| Phase 1 | 1 | Unknown 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Heart Failure NYHA Class II: new trials by email Literature Review of Heart Failure NYHA Class II trials Research Report on Heart Failure NYHA Class II
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure Barostim System, Usual care medical management - Heart Failure, Heart Failure NYHA Class II | Not applicable | Recruiting | CVRx, Inc. | 2500 | 2026-04-24 | 2026-10-21 |
| Heart Failure Management for Patient With CIED Remotely Monitored SmartSignalHF, HF RM standard of care - Heart Failure, Heart Failure NYHA Class II | Not applicable | Recruiting | Implicity | 1132 | 2025-12-19 | 2026-03-31 |
| Blood Flow Restricted Resistance Exercises Versus Low Level Laser on Cardiac Functions in Patients With Chronic Heart Failure Acupuncture LLLT:, Blood flow restricted resistance exercise:, Medical treatment - Heart Failure NYHA Class II | Not applicable | Completed | Cairo University | 60 | 2025-07-20 | 2026-08-31 |
| Association Between the Sit-To-Stand Test and the Prognosis of Patients With Heart Failure 1-minute sit-to-stand test - Heart Failure, Heart Failure NYHA Class IV | Active not recruiting | Centro Universitário Augusto Motta | 68 | 2025-07-16 | 2026-07-14 | |
| Optimization of STAR STAR condition 1, STAR condition 2, STAR condition 3 - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Not yet recruiting | UMC Utrecht | 320 | 2025-07-01 | 2025-07-15 |
| The Effect of Combination of Dapagliflozin and Sildenafil in Treatment of Heart Failure Patients With Secondary Pulmonary Hypertension Dapagliflozin (DAPA), Sildenafil - Heart Failure NYHA Class II | Not applicable | Completed | Fayoum University | 100 | 2025-01-20 | 2025-09-03 |
| A Preventive, Multidisciplinary Primary Care Intervention Organized Around a Therapeutic Garden: Acceptability to Patients Suffering from Cardio-neurovascular Pathology and to Those Involved in the Action. Intervention of prevention - Vascular Disease, Cardiovascular | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 157 | 2024-04-09 | 2024-10-17 |
| Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery Epicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling - Ischemic Heart Disease, Ischemic Cardiomyopathy | Not applicable | Recruiting | Hospital District of Helsinki and Uusimaa | 50 | 2024-04-01 | 2024-04-19 |
| Comprehensive Hybrid Cardiac Rehabilitation Trial on Heart Failure Comprehensive Initial Assessment, Continuous evaluation, Interval Exercise - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Recruiting | Universidad de La Frontera | 152 | 2024-04-01 | 2024-12-03 |
| Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron Deficiency Sucrosomial iron, Vitamin D, Ferric Carboxymaltose 50 MG/ML - Heart Failure, Iron-deficiency | Phase 4 | Unknown | University of Padova | 258 | 2024-01-15 | 2023-12-15 |
| PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III Cordella™ Pulmonary Artery Sensor System - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Recruiting | Endotronix, Inc. | 1750 | 2023-11-29 | 2026-06-29 |
| Gender-Based Differences in Heart Failure Hospitalizations Among Patients With Heart Failure Treated With Spironolactone Spironolactone - Heart Failure, Heart Failure With Reduced Ejection Fraction | Completed | Ahmad Abdullah Salawi | 509 | 2023-10-01 | 2025-03-24 | |
| A Study to Improve Physician-Youth Communication and Medical Decision Making We Chatt communication tool, Usual/standard care - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Completed | University of Michigan | 62 | 2023-09-14 | 2025-06-18 |
| Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure Heart Failure NYHA Class II, Heart Failure NYHA Class III | Active not recruiting | University of Pennsylvania | 40 | 2023-06-27 | 2026-06-04 | |
| Yoga Based Cardiac Rehabilitation in Heart Failure Failure Yoga-CaRe HF, Health Education - Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II | Not applicable | Recruiting | Centre for Chronic Disease Control, India | 3500 | 2023-04-24 | 2026-09-14 |
| CardioMEMS HF System Real-World Evidence Post-Approval Study CardioMEMS HF System - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Enrolling by invitation | Abbott Medical Devices | 2500 | 2022-12-15 | 2026-07-09 | |
| Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure Potassium sparing diuretic - Heart Failure, Heart Failure With Reduced Ejection Fraction | Completed | Alexandria University | 100 | 2022-10-15 | 2024-02-26 | |
| The Effect of Chan-Chuang Qigong on Fatigue, Exercise Capacity and Quality of Lifpatients With Heart Failure Chan-Chuang qigong - Heart Failure NYHA Class II | Not applicable | Completed | Chia-Lin Hsieh | 72 | 2022-09-16 | 2024-07-25 |
| Implementation and Cost-evaluation of a Smartphone-based Telemonitoring and Digital Support in Patients With HF Comunicare Solutions Smartphone Application, Completing a quality of life (QOL)-questionnaire - Heart Failure, Heart Failure NYHA Class II | Not applicable | Unknown | Comunicare Solutions SA | 330 | 2022-05-21 | 2022-08-04 |
| Biomarker Study: Heart Failure Patients at Risk Angiotensin 1-7, Saline solution - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Phase 1 / Phase 2 | Unknown | University of Arizona | 40 | 2022-04-01 | 2022-04-20 |
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Heart Failure (27) · Motor Activity (5) · Heart Failure, Systolic (3) · Coitus (2) · Amyloid Neuropathies, Familial (1) · Anemia, Iron-Deficiency (1) · Arteriovenous Fistula (1) · Atrial Fibrillation (1) · Bundle-Branch Block (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Diabetes Mellitus (1) · Heart Diseases (1) · Heart Failure, Diastolic (1)
Cardiovascular Diseases (29) · Heart Diseases (29) · Behavior (7) · Pathological Conditions, Signs and Symptoms (4) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Arrhythmias, Cardiac (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Nervous System Diseases (2) · Pathologic Processes (2) · Pathological Conditions, Anatomical (2) · Sexual Behavior (2) · Vascular Diseases (2) · Amyloid Neuropathies (1) · Amyloidosis (1)
sacubitril and valsartan sodium hydrate drug combination (2) · Activities of Daily Living (1) · BID protein, human (1) · Blood Specimen Collection (1) · Echocardiography (1) · Echocardiography, Transesophageal (1) · Enalapril (1) · Exercise (1) · Psychiatric Rehabilitation (1) · Resistance Training (1) · Saline Solution (1) · Sildenafil Citrate (1) · Sodium Channel Blockers (1) · Spironolactone (1) · Standard of Care (1)
Abbott Medical Devices (2) · Medtronic Cardiac Rhythm and Heart Failure (2) · Aalborg University (1) · Ahmad Abdullah Salawi (1) · Alexandria University (1) · Assistance Publique Hopitaux De Marseille (1) · BackBeat Medical Inc (1) · Boston Scientific Corporation (1) · CVRx, Inc. (1) · Cairo University (1) · Celestino Sardu (1) · Centre for Chronic Disease Control, India (1) · Centro Universitário Augusto Motta (1) · Chia-Lin Hsieh (1) · Clinision (1)
United States (14) · Egypt (3) · Belgium (2) · China (2) · Denmark (2) · France (2) · Pakistan (2) · Taiwan (2) · Brazil (1) · Brunei (1) · Canada (1) · Chile (1) · Finland (1) · Germany (1) · Greece (1)
Alexey B Zulkarnaev, MD, Prof. (1) · Birthe Dinesen, PhD (1) · Christopher M Celano, MD (1) · Dorairaj Prabhakaran, MD DM (Cardiology) (1) · Edward Karst (1) · Federico Capone, MD (1) · Gaetano Marrone (1) · Gohar Azhar, M.D (1) · Heleen Westland, PhD (1) · Jamie Pelzel, MD (1) · Javed Butler, MD (1) · Jens Refsgaard, MD, PhD (1) · John Parissis, MD (1) · Kazutaka Aonuma, MD (1)
PMID 28599667, PMID 29490680, PMID 31538944, PMID 33475727, PMID 34255642, PMID 34386535, PMID 34461042, PMID 34763080, PMID 35266003, PMID 35928510, PMID 36456066, PMID 36720768, PMID 36894879, PMID 36920122, PMID 37286262, PMID 37943225, PMID 39392161, PMID 39610971, PMID 40223608, PMID 41485016, PMID 42201276, PMID 42201288, PMID 42206402, PMID 42662629
K23HL145096 (1)