11 completed, 6 terminated, 4 recruiting, 2 unknown. 24 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 24 | Completed 11, Terminated 6, Recruiting 4, Unknown 2, Enrolling by invitation 1 |
Follow Heart Failure, Diastolic: new trials by email Literature Review of Heart Failure, Diastolic trials Research Report on Heart Failure, Diastolic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Incretin Therapies in Obesity-related HFpEF Tirzepatide - Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction | Phase 4 | Recruiting | Columbia University | 50 | 2026-08-07 | 2026-08-24 |
| Investigation on the Impact of Finerenone on Myocardial Remodeling in Patients With Diabetic Kidney Disease and Heart Failure Finerenone - Heart Failure and Preserved Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Cathay General Hospital | 40 | 2026-04-01 | 2026-03-02 |
| DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis Empagliflozin + Carvedilol, Carvedilol - Cirrhotic Cardiomyopathy, Empagliflozin | Phase 4 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 400 | 2026-04-01 | 2026-05-14 |
| Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction GLP-1RA - Heart Failure Preserved Ejection Fraction, Epicardial Adipose Tissue | Phase 4 | Recruiting | University of Virginia | 192 | 2025-11-20 | 2026-08-11 |
| The Efficacy of Enavogliflozin in Heart Failure With Preserved Ejection Fraction SGLT2 inhibitor - Heart Failure, Preserved Ejection Fraction | Phase 4 | Unknown | Samsung Medical Center | 154 | 2024-05-01 | 2024-04-08 |
| A Preliminary Study for INFORMED Beta blocker - Heart Failure, Heart Failure, Diastolic | Phase 4 | Recruiting | Weill Medical College of Cornell University | 18 | 2024-02-07 | 2026-08-21 |
| Impact of Empagliflozin on Functional Capacity in Heart Failure with Preserved Ejection Fraction Empagliflozin 10 MG - Heart Failure with Preserved Ejection Fraction, Heart Failure, Diastolic | Phase 4 | Completed | University of Texas Southwestern Medical Center | 8 | 2021-11-09 | 2024-09-19 |
| Impact of Beta-blockers on Physical Function in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2023-09-08 |
| Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2024-04-09 |
| Exercise Pulmonary Transit Time contrast echocardiography - Heart Failure, Diastolic | Phase 4 | Completed | Vanderbilt University Medical Center | 14 | 2020-08-27 | 2024-04-09 |
| Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure Catheter ablation, Rate or Rhythm control antiarrhythmic drugs for atrial fibrillation, Insertion of CardioMems Hemodynamic monitor - Atrial Fibrillation, Heart Failure | Phase 4 | Unknown | Electrophysiology Research Foundation | 360 | 2020-07-26 | 2024-05-23 |
| Evaluating Metabolic Mechanisms of Ertugliflozin in Diabetes & Heart Failure Ertugliflozin 5 mg, Placebo oral tablet - Heart Failure, Diastolic, Diabetes Mellitus, Type 2 | Phase 4 | Terminated | University Hospitals Cleveland Medical Center | 9 | 2020-03-01 | 2023-12-13 |
| Effects of Empagliflozin on Exercise Capacity and Left Ventricular Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction and Type-2 Diabetes Mellitus Empagliflozin, Standard care - Heart Failure, Diastolic, Diabetes Mellitus, Type 2 | Phase 4 | Completed | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | 70 | 2019-01-16 | 2022-01-11 |
| Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection Fraction Entresto™ 49Mg-51 mg tablet - Heart Failure With Preserved Ejection Fraction | Phase 4 | Completed | Mayo Clinic | 40 | 2018-06-25 | 2022-02-04 |
| Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF regadenoson - Heart Failure, Diastolic, Diastolic Heart Failure | Phase 4 | Completed | Marvin W. Kronenberg, M.D. | 55 | 2015-11-01 | 2021-02-02 |
| Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure Nebivolol - Pulmonary Hypertension, Diastolic Heart Failure | Phase 4 | Terminated | University of Florida | 11 | 2014-01-01 | 2022-02-10 |
| Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction Furosemide, Dopamine - Heart Failure, Diastolic | Phase 4 | Completed | Johns Hopkins University | 90 | 2013-08-01 | 2018-08-16 |
| Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart aldactone - Diastolic Heart Failure | Phase 4 | Completed | National Taiwan University Hospital | 40 | 2010-08-01 | 2013-09-17 |
| SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Sildenafil, Placebo - Heart Failure, Diastolic | Phase 4 | Completed | Jacob E Mueller | 70 | 2009-12-01 | 2012-05-24 |
| Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure Exenatide - Diabetes Mellitus, Type 2, Heart Failure, Diastolic | Phase 4 | Terminated | Baylor College of Medicine | 2 | 2009-07-01 | 2020-09-04 |
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Heart Failure (9) · Heart Diseases (4) · Diabetes Mellitus (3) · Diabetes Mellitus, Type 2 (3) · Cardiovascular Diseases (2) · Hypertension, Pulmonary (2) · Ascites (1) · Atrial Fibrillation (1) · Dyspnea (1) · Edema (1) · Endocrine System Diseases (1) · Fatigue (1) · Fibrosis (1) · Glucose Metabolism Disorders (1)
Cardiovascular Diseases (22) · Heart Diseases (20) · Heart Failure (15) · Nutritional and Metabolic Diseases (5) · Metabolic Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Endocrine System Diseases (3) · Glucose Metabolism Disorders (3) · Respiratory Tract Diseases (3) · Vascular Diseases (3) · Hypertension (2) · Lung Diseases (2) · Pathologic Processes (2) · Signs and Symptoms (2) · Arrhythmias, Cardiac (1)
Adrenergic beta-Antagonists (3) · Carvedilol (3) · Nebivolol (3) · empagliflozin (3) · Acebutolol (2) · Atenolol (2) · Betaxolol (2) · Bisoprolol (2) · Labetalol (2) · Metoprolol (2) · Nadolol (2) · Penbutolol (2) · Pindolol (2) · Propranolol (2) · Sotalol (2)
Weill Medical College of Cornell University (3) · Baylor College of Medicine (2) · University of Texas Southwestern Medical Center (2) · Cathay General Hospital (1) · Columbia University (1) · Electrophysiology Research Foundation (1) · Jacob E Mueller (1) · Johns Hopkins University (1) · M.D. Anderson Cancer Center (1) · Marvin W. Kronenberg, M.D. (1) · Mayo Clinic (1) · National Medical Research Center for Cardiology, Ministry of Health of Russian Federation (1) · National Taiwan University Hospital (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Samsung Medical Center (1)
United States (17) · Denmark (1) · Germany (1) · India (1) · Russia (1) · South Korea (1) · Switzerland (1) · Taiwan (1)
Parag Goyal, MD (2) · Amit Patel, MD (1) · Andrea Natale, MD (1) · Anton Borisov, MD (1) · David Aguilar, MD (1) · Elissa A Driggin, MD (1) · Fernando Torres, MD (1) · Jean-Bernard Durand, MD (1) · Jeong Hoon Yang, MD, PhD (1) · Julio Duarte, PharmD, PhD (1) · Karla M Kurrelmeyer, MD (1) · Kavita Kavita, MD (1) · Kelly M Chin, MD (1) · Ken Monahan, MD (1)
PMID 23406672, PMID 23671819, PMID 24331202, PMID 24905296, PMID 30098962, PMID 36356959, PMID 38775253, PMID 40346546
K76AG064428 (2), 2009 (1), K01HL092585 (1), K23GM112014 (1), R21AG053512 (1)