43 completed, 11 unknown, 9 terminated, 6 recruiting. 77 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 77 | Completed 43, Unknown 11, Terminated 9, Recruiting 6, Not yet recruiting 3, Active not recruiting 2, Withdrawn 2, Enrolling by invitation 1 |
Follow Heart Failure, Diastolic: new trials by email Literature Review of Heart Failure, Diastolic trials Research Report on Heart Failure, Diastolic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Exercise, Mediterranean Diet and Inflammation in Heart Failure Structured exercise training program, Mediterranean diet counseling, Standard heart failure management - Heart Failure, Heart Failure Preserved Ejection Fraction | Not applicable | Not yet recruiting | Hospital Severo Ochoa | 214 | 2026-11-01 | 2026-10-21 |
| PrEcision Pacing in HFpEF: the PEP-HFpEF Trial Individualized myPACE pacemaker programming - Heart Failure and Preserved Ejection Fraction, Heart Failure New York Heart Association Class III | Not applicable | Recruiting | Tufts Medical Center | 36 | 2026-10-01 | 2026-10-29 |
| eHealth Lifestyle Intervention To Enhance Outcomes in HFpEF Digital lifestyle education program, Usual Care - Heart Failure and Preserved Ejection Fraction, Obesity & Overweight | Not applicable | Not yet recruiting | Maimónides Biomedical Research Institute of Córdoba | 52 | 2026-09-01 | 2026-06-22 |
| Dancing as an Alternative to the Traditional Exercising in Older Adults With Cardiac Diseases Dancing Intervention, Exercising - Heart Failure and Preserved Ejection Fraction | Not applicable | Active not recruiting | University College, London | 120 | 2026-08-01 | 2026-09-11 |
| Coronary Sinus Reducer For The Management Of Symptomatic Heart Failure Coronary Sinus Reducer - Heart Failure Preserved Ejection Fraction | Not applicable | Enrolling by invitation | Mayo Clinic | 35 | 2025-10-16 | 2026-08-05 |
| Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure Acetazolamide, Metolazone - Acute Decompensated Heart Failure, Heart Failure, Diastolic | Not applicable | Recruiting | University of Health Sciences Lahore | 320 | 2025-10-11 | 2025-10-03 |
| Mechanistic Insights From Temporary Pacing in HFpEF Acute Haemodynamic Study - Heart Failure Preserved Ejection Fraction, Pacing | Not applicable | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 10 | 2024-07-01 | 2024-06-20 |
| Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure Aortix System - Heart Failure, Cardiorenal Syndrome | Not applicable | Recruiting | Procyrion | 320 | 2023-08-23 | 2026-08-25 |
| External Body Pressure in Heart Failure With Preserved Ejection Fraction Positive or negative pressure - Heart Failure, Diastolic | Not applicable | Terminated | Duke University | 27 | 2023-04-21 | 2026-09-11 |
| Pilot Study Lp299v Supplementation in Chronic Heart Failure Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule - Heart Failure, Heart Failure With Reduced Ejection Fraction | Not applicable | Completed | Medical College of Wisconsin | 10 | 2023-02-20 | 2026-05-01 |
| RESPONDER-HF Trial Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE) - Heart Failure, Heart Failure, Diastolic | Not applicable | Active not recruiting | Corvia Medical | 750 | 2022-11-17 | 2026-03-18 |
| Safety and Efficacy Study of AI LVEF Automated annotation of the left ventricle through deep learning, Sonographer Measurement of LVEF - Heart Failure, Systolic, Heart Failure, Diastolic | Not applicable | Completed | Cedars-Sinai Medical Center | 3495 | 2022-04-01 | 2022-07-05 |
| Parasympathetic Augmentation Via Respiratory Training for Patients With Systolic Heart Failure Meo Health Breathing and humming exercises - Diastolic Heart Failure | Not applicable | Terminated | Lancaster General Hospital | 65 | 2022-02-07 | 2025-10-23 |
| Assessment of CCM in HF With Higher Ejection Fraction Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, OPTIMIZER™ Smart Mini System - Heart Failure, Heart Failure With Preserved Ejection Fraction | Not applicable | Recruiting | Impulse Dynamics | 1500 | 2022-02-03 | 2026-10-23 |
| The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function Parasym - Atrial Fibrillation, Heart Failure, Diastolic | Not applicable | Unknown | University of Oklahoma | 90 | 2021-11-30 | 2024-02-21 |
| sPERMIdine supplemenTation on Metabolic, Neuronal and Cardiovascular Response to Exercise TRAINING spermidineLife, Placebo - Heart Failure, Diastolic | Not applicable | Unknown | University Medicine Greifswald | 30 | 2021-08-11 | 2022-05-25 |
| Effect of Different Types of Aerobic Training on Peak VO2 and Ejection Fraction for Diastolic Heart Failure Patients; a Comparative Randomized Control Trial aerobic exercise for upper limb, aerobic exercise for lower limb - Effect of Different Types of Aerobic Training on Diastolic Heart Failure Patients | Not applicable | Completed | Beni-Suef University | 40 | 2021-08-01 | 2022-12-05 |
| Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease Optical coherence tomography(-angiography) OCT(A), Fundus pictures, DVA 3.0 - Kidney Diseases, Diastolic Heart Failure | Not applicable | Unknown | Universitaire Ziekenhuizen KU Leuven | 1000 | 2021-07-06 | 2024-07-03 |
| Effects of Postural Balance Exercises in Patients With Heart Failure Core stabilization group(CSG), Wobble board group (WBG) - Heart Failure, Systolic Heart Failure | Not applicable | Completed | Giresun University | 42 | 2021-06-15 | 2023-01-31 |
| Physiologic Accelerated Pacing as a Treatment in Patients With Heart Failure With Preserved Ejection Fraction Dual chamber pacemaker, Accelerated Physiologic Pacing, Nocturnal Pacing - Heart Failure, Diastolic | Not applicable | Completed | Daniel L Lustgarten | 20 | 2021-02-23 | 2023-07-28 |
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Heart Failure (34) · Heart Failure, Systolic (12) · Motor Activity (7) · Obesity (4) · Cardio-Renal Syndrome (3) · Heart Murmurs (3) · Hypertension (3) · Atrial Fibrillation (2) · Amyloidosis (1) · Amyloidosis, Hereditary, Transthyretin-Related (1) · Aortic Valve Stenosis (1) · Bradycardia (1) · Cardiovascular Diseases (1) · Fibrosis (1)
Heart Diseases (77) · Cardiovascular Diseases (76) · Heart Failure (43) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (8) · Behavior (7) · Pathologic Processes (7) · Body Weight (5) · Nutritional and Metabolic Diseases (5) · Vascular Diseases (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Male Urogenital Diseases (4) · Nutrition Disorders (4) · Overnutrition (4)
Exercise (7) · High-Intensity Interval Training (5) · Blood Specimen Collection (3) · Atorvastatin (2) · Diet (2) · Diet, Sodium-Restricted (2) · Dietary Approaches To Stop Hypertension (2) · Resistance Training (2) · Yoga (2) · Acetazolamide (1) · Amino Acids, Essential (1) · Biomarkers (1) · Cardiac Resynchronization Therapy Devices (1) · Control Groups (1) · Diet Therapy (1)
Mayo Clinic (5) · University of Michigan (3) · University of Texas Southwestern Medical Center (3) · Arizona State University (2) · CorAssist Cadiovascular Ltd. (2) · Hospital de Clinicas de Porto Alegre (2) · Impulse Dynamics (2) · Procyrion (2) · Tufts Medical Center (2) · University of Göttingen (2) · University of Oklahoma (2) · Abbott Medical Devices (1) · Beni-Suef University (1) · Boston Scientific Corporation (1) · CVRx, Inc. (1)
United States (40) · Germany (8) · Belgium (4) · Australia (3) · Brazil (3) · Italy (3) · Canada (2) · Czechia (2) · France (2) · Norway (2) · Spain (2) · Sweden (2) · Austria (1) · Azerbaijan (1) · China (1)
Benjamin D Levine, MD (2) · Dalane W Kitzman, MD (2) · Scott L Hummel, MD MS (2) · Andreas Schuster, MD, PhD (1) · Anne Catherine Pouleur (1) · Anthony DeMaria, MD (1) · Antonio Abbate, MD, PhD (1) · Axel Linke, M.D. (1) · Barry Borlaug, MD (1) · Burkert Pieske, M.D. (1) · Carsten Tschoepe, Prof. (1) · Celestino Sardu, MD, MSc, PhD (1) · Chaowu Yan, PhD and MD (1) · Christiaan Vrints, M.D. (1)
PMID 19850207, PMID 21869636, PMID 23033371, PMID 23108436, PMID 23985432, PMID 25190739, PMID 25354950, PMID 26053189, PMID 26497755, PMID 26746456, PMID 27693420, PMID 28673328, PMID 29550319, PMID 30007558, PMID 30055633, PMID 30086783, PMID 30560316, PMID 31273863, PMID 31865771, PMID 31964186, PMID 32063068, PMID 32168423, PMID 32269341, PMID 32434700, PMID 32831121, PMID 33472397, PMID 33560320, PMID 34046195, PMID 34344169, PMID 34427605, PMID 34461042, PMID 34508569, PMID 34543068, PMID 34713711, PMID 34774747, PMID 35222057, PMID 35266003, PMID 35361442, PMID 35855646, PMID 36200450, PMID 36314122, PMID 36423376, PMID 36456066, PMID 36524474, PMID 36691723, PMID 36723919, PMID 36842486, PMID 36871285, PMID 36892488, PMID 36897745
2014 (1), R01AG018915 (1), R03AG064371 (1), R37AG018915 (1)