6 completed, 2 terminated, 1 active not recruiting, 1 enrolling by invitation. 11 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 6, Terminated 2, Active not recruiting 1, Enrolling by invitation 1, Recruiting 1 |
Follow Familial Primary Pulmonary Hypertension: new trials by email Literature Review of Familial Primary Pulmonary Hypertension trials Research Report on Familial Primary Pulmonary Hypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EVE TRIAL , ALMA SYSTAM Alma System - Postpartum Haemorrhage (PPH), PPH | Phase 3 | Recruiting | ResQ Medical Ltd | 50 | 2026-01-11 | 2026-03-30 |
| A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension Ralinepag - PAH, Pulmonary Hypertension | Phase 3 | Enrolling by invitation | United Therapeutics | 1000 | 2019-09-23 | 2026-10-06 |
| Extension Study for Participants in LIQ861 Trials to Evaluate the Long-term Safety of Dry Powder Inhalation of Treprostinil LIQ861 Inhaled Treprostinil - Primary Pulmonary Hypertension | Phase 3 | Active not recruiting | Liquidia Technologies, Inc. | 92 | 2019-07-18 | 2025-01-29 |
| A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients Ralinepag, Placebo - PAH, Pulmonary Hypertension | Phase 3 | Completed | United Therapeutics | 687 | 2019-01-24 | 2026-06-16 |
| A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension Esuberaprost, Placebo - Pulmonary Arterial Hypertension | Phase 3 | Terminated | Lung Biotechnology PBC | 112 | 2018-12-10 | 2020-09-07 |
| Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil LIQ861 Inhaled Treprostinil - Primary Pulmonary Hypertension | Phase 3 | Completed | Liquidia Technologies, Inc. | 121 | 2018-01-02 | 2024-07-30 |
| Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol misoprostol, carbetocin - Severe Pre-eclampsia, Postpartum Condition or Complication | Phase 3 | Completed | khalid abd aziz mohamed | 60 | 2013-03-01 | 2017-02-15 |
| Inhaled Iloprost (Ventavis): Efficacy, Safety, and Pharmacokinetics (PK) Confirmation Study Iloprost (Ventavis inhaled, BAYQ6256) - Hypertension, Pulmonary | Phase 3 | Completed | Bayer | 27 | 2012-06-19 | 2017-12-07 |
| Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing Nitric Oxide for inhalation, Oxygen, Nitric Oxide plus Oxygen - Idiopathic Pulmonary Arterial Hypertension, Cardiomyopathy | Phase 3 | Completed | Mallinckrodt | 136 | 2004-09-01 | 2019-12-20 |
| Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure Inhaled nitric oxide, Placebo - Infant, Newborn, Infant, Low Birth Weight | Phase 3 | Terminated | NICHD Neonatal Research Network | 420 | 2001-01-01 | 2017-09-26 |
| Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension UT-15 - Pulmonary Hypertension | Phase 3 | Completed | United Therapeutics | 1998-10-01 | 2015-03-25 |
Hypertension, Pulmonary (6) · Pulmonary Arterial Hypertension (5) · Connective Tissue Diseases (4) · Hypertension (4) · Respiratory Tract Diseases (4) · Cardiovascular Diseases (3) · Lung Diseases (3) · Vascular Diseases (3) · Acute Lung Injury (1) · Cardiomyopathies (1) · Heart Defects, Congenital (1) · Pneumonia (1) · Postpartum Hemorrhage (1) · Pre-Eclampsia (1)
Lung Diseases (8) · Respiratory Tract Diseases (7) · Hypertension, Pulmonary (5) · Cardiovascular Diseases (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Skin and Connective Tissue Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (3) · Pregnancy Complications (3) · Urogenital Diseases (3) · Vascular Diseases (3) · Hypertension (2) · Obstetric Labor Complications (2) · Respiration Disorders (2) · Cardiovascular Abnormalities (1)
ralinepag (2) · Endothelium-Dependent Relaxing Factors (1) · Iloprost (1) · Inhalation (1) · Misoprostol (1) · Nitric Oxide (1) · Oxygen (1) · beraprost (1) · carbetocin (1) · treprostinil (1)
United Therapeutics (3) · Liquidia Technologies, Inc. (2) · Bayer (1) · Lung Biotechnology PBC (1) · Mallinckrodt (1) · NICHD Neonatal Research Network (1) · ResQ Medical Ltd (1) · khalid abd aziz mohamed (1)
United States (9) · Israel (4) · France (3) · Netherlands (3) · Spain (3) · United Kingdom (3) · Argentina (2) · Australia (2) · Austria (2) · Belgium (2) · Brazil (2) · Bulgaria (2) · Canada (2) · Chile (2) · China (2)
Nicholas S Hill, MD (2) · Abbot R. Laptook, MD (1) · Charles R. Rosenfeld, MD (1) · Dale L. Phelps, MD (1) · Edward F. Donovan, MD (1) · G. Ganesh Konduri, MD (1) · James A. Lemons, MD (1) · James Walker Crow (1) · Jon E. Tyson, MD MPH (1) · Krisa P. Van Meurs, MD (1) · Mark L. Hudak, MD (1) · Neil N. Finer, MD (1) · Richard A. Ehrenkranz, MD (1)
PMID 16000352, PMID 17443204, PMID 17517240, PMID 17586184, PMID 18337740, PMID 19067285, PMID 20405117, PMID 27001191, PMID 33282202, PMID 42520828
2004 (1), M01RR000032 (1), M01RR000044 (1), M01RR000070 (1), M01RR000633 (1), M01RR000750 (1), M01RR006022 (1), M01RR007122 (1), M01RR008084 (1), M01RR016587 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD027853 (1), U10HD027856 (1)