60 completed, 23 terminated, 15 withdrawn, 8 recruiting. 38 Phase 2, 32 Phase 3, 20 Phase 1, 16 Phase 4, 4 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + Dinutuximab Radiation: 131I-MIBG, Dinutuximab, Vorinostat - Neuroblastoma | Phase 2 | Not yet recruiting | New Approaches to Neuroblastoma Therapy Consortium | 118 | 2026-12-31 | 2026-08-21 |
| Study to Evaluate the Safety and Efficacy of the GGTA1 KO Thymokidney in Patients With ESRD GGTA1 KO Thymokidney - ESRD (End-Stage Renal Disease), Kidney Transplantation | Phase 1 / Phase 2 | Recruiting | United Therapeutics | 50 | 2026-11-01 | 2026-09-09 |
| Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With ESRD 10 GE Xenokidney - ESRD (End-Stage Renal Disease), Kidney Transplantation | Phase 1 / Phase 2 | Recruiting | United Therapeutics | 50 | 2025-10-29 | 2026-03-27 |
| Effects of Inhaled Treprostinil on Exercise Performance in Exercise Induced Pulmonary Hypertension Inhaled treprostinil - Pulmonary Hypertension | Early Phase 1 | Not yet recruiting | University of California, San Diego | 8 | 2025-10-01 | 2025-08-24 |
| Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia Inhaled Treprostinil (Tyvaso Nebulizer) - COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia | Phase 2 | Recruiting | Bastiaan Driehuys | 10 | 2025-09-29 | 2026-08-27 |
| Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension ECG-based AI Device - Results Returned to Investigator, Echocardiogram and Right Heart Catheterization, ECG-based AI Device - Results Not Returned to Investigator - Pulmonary Hypertension, Interstitial Lung Disease (ILD) | Not applicable | Recruiting | Tempus AI | 900 | 2025-07-23 | 2026-11-03 |
| DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD) Prospective study assessments - Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension | Recruiting | United Therapeutics | 900 | 2025-01-23 | 2026-08-26 | |
| NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial Universal Donor (UD) TGFβi NK Cells, Temozolomide, Irinotecan - Neuroblastoma | Phase 2 | Recruiting | New Approaches to Neuroblastoma Therapy Consortium | 62 | 2024-12-16 | 2026-07-20 |
| Home Rehabilitation Improves Cardiac Effort in Pulmonary Arterial Hypertension Exercise, Standard of Care - Pulmonary Arterial Hypertension PAH | Not applicable | Active not recruiting | University of Rochester | 55 | 2024-07-29 | 2026-07-15 |
| Porcine Kidney Xenotransplantation in Patients With End-Stage Kidney Disease UKidney - Kidney Failure, Chronic | Phase 1 | Withdrawn | University of Alabama at Birmingham | 2024-01-31 | 2024-02-01 | |
| Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF) Placebo, Inhaled Treprostinil, Treprostinil Ultrasonic Nebulizer - Progressive Pulmonary Fibrosis, Interstitial Lung Disease | Phase 3 | Recruiting | United Therapeutics | 698 | 2023-10-30 | 2026-07-13 |
| Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection Right heart catheterization (RHC) - Interstitial Lung Disease, Pulmonary Hypertension | Completed | United Therapeutics | 314 | 2023-08-11 | 2026-05-28 | |
| Evaluate Real-World Use of Next Generation Infusion Pumps to Administer Remodulin Remunity Pump for Remodulin - Pulmonary Arterial Hypertension | Terminated | United Therapeutics | 9 | 2023-07-05 | 2025-01-16 | |
| A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension Treprostinil, Right Heart Catheterization (RHC) while exercising, Optional Muscle Biopsy - Pulmonary Arterial Hypertension, Interstitial Lung Disease | Phase 2 | Completed | Mayo Clinic | 29 | 2023-03-13 | 2025-12-03 |
| Rapid Administration Pilot for Infusing Dinutuximab Dinutuximab with Chemotherapy - Neuroblastoma | Phase 2 | Active not recruiting | Children's Hospital Los Angeles | 30 | 2022-11-29 | 2026-09-17 |
| A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension Parenteral Treprostinil, Oral Treprostinil - Pulmonary Arterial Hypertension | Phase 4 | Active not recruiting | United Therapeutics | 52 | 2022-10-20 | 2025-12-09 |
| Multinational Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis Placebo, Inhaled Treprostinil, Treprostinil Ultrasonic Nebulizer - Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease | Phase 3 | Completed | United Therapeutics | 597 | 2022-09-12 | 2026-10-15 |
| Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease Inhaled Treprostinil, Treprostinil Ultrasonic Nebulizer - Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease | Phase 3 | Enrolling by invitation | United Therapeutics | 1850 | 2022-09-06 | 2026-10-19 |
| Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis Placebo, Inhaled Treprostinil, Treprostinil Ultrasonic Nebulizer - Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease | Phase 3 | Completed | United Therapeutics | 598 | 2021-06-01 | 2026-05-05 |
| Study of Ralinepag on Exercise Capacity by Cardiopulmonary Exercise Testing (CPET) in WHO Group 1 PH Subjects Ralinepag, Placebo - Pulmonary Hypertension, Pulmonary Arterial Hypertension | Phase 3 | Terminated | United Therapeutics | 10 | 2021-01-20 | 2026-07-06 |
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Pulmonary Arterial Hypertension (57) · Hypertension, Pulmonary (42) · Lung Diseases, Interstitial (12) · Neuroblastoma (9) · Hypertension (5) · Pulmonary Disease, Chronic Obstructive (5) · Scleroderma, Systemic (5) · Idiopathic Pulmonary Fibrosis (4) · Lung Diseases (4) · Vascular Diseases (4) · Chronic Limb-Threatening Ischemia (3) · Connective Tissue Diseases (3) · Familial Primary Pulmonary Hypertension (3) · Kidney Failure, Chronic (3) · Peripheral Vascular Diseases (3)
treprostinil (70) · dinutuximab (9) · ralinepag (5) · Irinotecan (4) · Sugars (4) · Tadalafil (4) · Epoprostenol (3) · Granulocyte-Macrophage Colony-Stimulating Factor (3) · Injections (3) · Temozolomide (3) · sargramostim (3) · 3-Iodobenzylguanidine (2) · Capsaicin (2) · Colony-Stimulating Factors (2) · Isotretinoin (2)
United States (101) · Australia (16) · Canada (16) · Italy (15) · Israel (14) · United Kingdom (14) · France (13) · Germany (12) · Spain (12) · Belgium (11) · Poland (11) · Netherlands (10) · Argentina (9) · Austria (9) · Mexico (9)
Aziz Laurent, MD (4) · Rajan Saggar, MD (4) · Araz Marachelian, MD, MS (2) · Cynthia Madden, MD, MPH (2) · James Seibold, MD (2) · Junbo Ge (2) · Kevin Laliberte, PharmD (2) · Mardi Gomberg-Maitland, MD (2) · Aaron Waxman, MD, PhD (1) · Aaron Waxman, MD/PhD (1) · Abubakr A Bajwa, MD, FCCP (1) · Ali Ataya, MD (1) · Amadeo Marcos, MD (1) · Ami Desai, MD (1) · Araz Marachelian, MD (1)
PMID 41627369, PMID 42776606, PMID 20022264, PMID 20430262, PMID 22628490, PMID 23307827, PMID 23597147, PMID 23669822, PMID 24062200, PMID 24431095, PMID 24603117, PMID 24742768, PMID 26360334, PMID 27396777, PMID 27683610, PMID 28090293, PMID 28090295, PMID 28090299, PMID 28549783, PMID 29251556, PMID 31391223, PMID 31765604, PMID 31858338, PMID 32343642, PMID 33095030, PMID 33440084, PMID 34214475, PMID 34718447, PMID 35278766, PMID 35514770, PMID 36115497, PMID 36822669, PMID 37532157, PMID 38055186, PMID 38182130, PMID 38811045, PMID 40549985, PMID 40711711, PMID 40882760, PMID 41806275, PMID 41812190, PMID 42149993, PMID 42520828, PMID 42548323
P01CA217959 (1), P50HL084946 (1), U10CA098543 (1), U10CA180886 (1)