13 completed. 13 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 13 | Completed 13 |
Follow Esketamine: new trials by email Literature Review of Esketamine trials Research Report on Esketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients Dexmedetomidine, Dexmedetomidine-esketamine combination - Older Patients, Postoperative Care | Phase 4 | Completed | Peking University First Hospital | 100 | 2025-10-21 | 2026-06-30 |
| Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia sufentanil-ropivacaine combination, dexmedetomidine-esketamine-ropivacaine combination 1, dexmedetomidine-esketamine-ropivacaine combination 2 - Epidural Analgesia, Labor Pain | Phase 4 | Completed | Peking University First Hospital | 300 | 2025-09-05 | 2026-04-13 |
| Different Doses of Dexmedetomidine Combined With Esketamine in Women Undergoing Cesarean Delivery Esketamine 0.2 mg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.1 µg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.15 µg/kg - Cesarean Delivery, Esketamine | Phase 4 | Completed | Peking University First Hospital | 120 | 2024-10-08 | 2024-12-30 |
| Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA Dexmedetomidine-esketamine combination, Placebo - Obstructive Sleep Apnea, Surgery | Phase 4 | Completed | Peking University First Hospital | 100 | 2024-09-11 | 2026-09-04 |
| Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium Dexmedetomidine, Esketamine, Normal saline - Older Patients, Nasal Administration | Phase 4 | Completed | Peking University First Hospital | 340 | 2024-09-02 | 2025-07-31 |
| Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality Dexmedetomidine, Esketamine, Normal saline - Old Age, Knee Replacement Surgery | Phase 4 | Completed | Peking University First Hospital | 154 | 2024-01-03 | 2026-07-06 |
| Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients Dexmedetomidine-esketamine, Routine sedation and analgesia - Intensive Care Unit, Mechanical Ventilation | Phase 4 | Completed | Peking University First Hospital | 174 | 2023-11-01 | 2025-12-05 |
| Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality Dexmedetomidine, Esketamine, Normal saline - Breast Cancer, Perioperative Period | Phase 4 | Completed | Peking University First Hospital | 180 | 2023-05-22 | 2025-07-31 |
| Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes Esketamine, Dexmedetomidine, Sufentanil - Scoliosis Correction, Postoperative Analgesia | Phase 4 | Completed | Peking University First Hospital | 199 | 2023-01-30 | 2025-07-30 |
| An Exploratory Study of Esketamine in Patients After Thoracoscopic Surgery Esketamine - Esketamine, Thoracoscopic Surgery | Phase 4 | Completed | The Second Affiliated Hospital of Chongqing Medical University | 80 | 2022-07-07 | 2023-08-16 |
| Esketamine and Butorphanol for Post-Lobectomy Pain Esketamine, Butorphanol - Esketamine, Pain | Phase 4 | Completed | Second People's Hospital of Hefei City | 223 | 2022-03-01 | 2024-05-06 |
| Anesthesia for Loop Electrosurgical Excision Procedure (LEEP). intravenous injection of propofol only, intravenous injection of propofol +esketamine - Esketamine, Loop Electrosurgical Excision | Phase 4 | Completed | Qian Wu | 90 | 2022-01-07 | 2024-08-28 |
| The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Disease Esketamine, Placebo - Crohn Disease, Depression | Phase 4 | Completed | Jinling Hospital, China | 120 | 2020-09-01 | 2023-04-04 |
Sleep Initiation and Maintenance Disorders (3) · Breast Neoplasms (1) · Crohn Disease (1) · Delirium (1) · Depression (1) · Emergence Delirium (1) · Labor Pain (1) · Pain (1) · Pain, Postoperative (1) · Sleep Apnea, Obstructive (1) · Thoracic Diseases (1)
Nervous System Diseases (6) · Mental Disorders (5) · Neurologic Manifestations (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Dyssomnias (4) · Sleep Disorders, Intrinsic (4) · Sleep Wake Disorders (4) · Confusion (2) · Neurobehavioral Manifestations (2) · Neurocognitive Disorders (2) · Pain (2) · Pathologic Processes (2) · Postoperative Complications (2) · Respiratory Tract Diseases (2)
Esketamine (8) · Dexmedetomidine (6) · Saline Solution (3) · Analgesia (1) · Butorphanol (1) · Ketamine (1) · Sufentanil (1)
Peking University First Hospital (9) · Jinling Hospital, China (1) · Qian Wu (1) · Second People's Hospital of Hefei City (1) · The Second Affiliated Hospital of Chongqing Medical University (1)
China (13)
Dong-Xin Wang, MD, PhD (4) · Dong-Xin Wang, MD,PhD (3) · Dong-Xin Wang, M.D. (1) · Dong-Xin Wang, M.D., PhD. (1) · Gang Y Hao (1) · Ji Qing (1) · Junbao Zhang, MD (1) · Wensheng He, MD (1) · Xianwen Hu, PhD (1) · Xin Wang, MD (1) · Zicheng Wang, MD (1)
PMID 26832926, PMID 33078536, PMID 33533982, PMID 37302963, PMID 38322862, PMID 39488417, PMID 39751970, PMID 39753406, PMID 39773190, PMID 39806707