11 completed, 10 unknown, 6 enrolling by invitation, 5 recruiting. 23 Not applicable, 3 Phase 1, 3 Phase 2, 1 Early Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sleep Disruption Pattern - Epilepsy Monitoring Unit Alarm system - Epilepsy Intractable | Not applicable | Not yet recruiting | Duke University | 75 | 2026-10-01 | 2026-09-08 |
| Pediatric Epilepsy Cedrus RB series response pad; Adtech Behnke-Fried micro-electrodes; Neuralynx or Blackrock electrophysiology system; Blackrock Cerestim or Natus Nicolet stimulator - Epilepsy Intractable | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 200 | 2026-07-01 | 2026-10-06 |
| Neuronal Mechanisms of Learning and Utilizing Abstract Representations Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator - Epilepsy Intractable | Not applicable | Enrolling by invitation | Cedars-Sinai Medical Center | 114 | 2026-03-30 | 2026-09-15 |
| Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042 NPT 2042 (Reference formula/Formulation 1), NPT 2042 (Test formula/Formulation 2) - Epilepsy, Alzheimer Disease | Phase 1 | Completed | NeuroPro Therapeutics, Inc. | 8 | 2025-09-29 | 2026-04-03 |
| Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs Dreem headband - Epilepsy Intractable | Not applicable | Recruiting | Duke University | 35 | 2025-05-01 | 2026-10-19 |
| The Mosaic Brain: a New Diagnostic Approach in Focal Epilepsies Epilepsy Intractable, Epilepsy in Children | Unknown | Institute of Child Health | 40 | 2024-10-01 | 2024-09-19 | |
| Spatial Scene Recognition Memory in Epilepsy Surgery Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I) - Focal Epilepsy, Temporal Lobe Epilepsy | Not applicable | Recruiting | University of California, Davis | 620 | 2024-07-01 | 2026-05-12 |
| 5-SENSE Score Validation Study Stereoelectroencephalography (SEEG) - Epilepsy Intractable | Enrolling by invitation | Duke University | 400 | 2024-01-09 | 2026-06-05 | |
| Neural Mechanisms of Social Attribution From Faces Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator - Epilepsy Intractable | Not applicable | Enrolling by invitation | Cedars-Sinai Medical Center | 100 | 2023-12-15 | 2026-09-16 |
| Neural Computations of Goal-directed Decision-making Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system - Epilepsy Intractable | Not applicable | Enrolling by invitation | Cedars-Sinai Medical Center | 50 | 2023-08-01 | 2026-07-23 |
| A Multifaceted Assessment of Eating Behaviors, Anthropometric Measurements and Body Composition in Pediatric Patients With Drug-resistant Epilepsy on a Ketogenic Diet and Healthy Children Epilepsy Intractable | Active not recruiting | Wroclaw Medical University | 150 | 2023-04-12 | 2026-07-20 | |
| Safety and Pharmacokinetic Study of NPT 2042 Soft-gelatin Capsules Administered Orally to Healthy Adult Subjects NPT 2042 (bumetanide analog) or Matching Placebo - Epilepsy, Alzheimer Disease | Phase 1 | Completed | NeuroPro Therapeutics, Inc. | 50 | 2022-10-20 | 2023-04-04 |
| Ketogenic Diet in Pediatric Intractable Epilepsy Early ketogenic diet combined with conventional pharmacotherapy., Common diet combined with conventional pharmacotherapy - Epilepsy in Children, Epilepsy Intractable | Not applicable | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 59 | 2022-08-11 | 2024-03-15 |
| Neural Mechanisms of Spatial Representations Beyond the Self Self-navigation task, Observation task - Epilepsy Intractable | Not applicable | Recruiting | Boston University Charles River Campus | 60 | 2022-08-06 | 2026-07-27 |
| Multicenter Comparison of Interictal HFO as a Predictor of Seizure Freedom HFO analysis - Epilepsy Intractable | Unknown | University of Zurich | 300 | 2022-05-01 | 2023-12-07 | |
| Add-on Clioquinol in Drug-resistant Childhood Epilepsy: an Exploratory Study Clioquinol - Epilepsy Intractable | Phase 2 | Completed | KU Leuven | 10 | 2022-03-01 | 2026-10-20 |
| Thermocoagulation in Drug Resistant Focal Epilepsy Radiofrequency thermocoagulation - Epilepsy, Seizures, Focal | Not applicable | Unknown | State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | 75 | 2022-02-07 | 2024-07-23 |
| Contribution of Genetics, Non-invasive Methods and Neuropsychology in Focal Cryptogenic Epilepsies Standard of care, Functional magnetic resonance imaging-Electroencephalogram combined analysis, High density- electroencephalogram or 7 Tesla magnetic resonance imaging - Epilepsies, Partial, Epilepsy Intractable | Not applicable | Completed | IRCCS Eugenio Medea | 5 | 2021-07-15 | 2025-05-01 |
| Localizing Epileptic Networks Using MRI and iEEG 3T Magnetic Resonance Imaging, Intracranial electroencephalography recordings, 7T Magnetic Resonance Imaging - Epilepsy, Epilepsy Intractable | Early Phase 1 | Recruiting | University of Pennsylvania | 290 | 2021-03-01 | 2026-02-13 |
| Ciprofloxacin in Drug-resistant Epilepsy Ciprofloxacin Oral Product - Epilepsy Intractable | Not applicable | Completed | Mazandaran University of Medical Sciences | 23 | 2020-10-01 | 2021-06-07 |
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Drug Resistant Epilepsy (36) · Epilepsy (15) · Epilepsies, Partial (5) · Seizures (4) · Central Nervous System Diseases (3) · Alzheimer Disease (2) · Epilepsy, Temporal Lobe (2) · Attention Deficit Disorder with Hyperactivity (1) · Brain Diseases (1) · Glut1 Deficiency Syndrome (1) · Ketosis (1) · Memory Disorders (1) · Nervous System Diseases (1) · Orientation, Spatial (1)
Brain Diseases (35) · Nervous System Diseases (35) · Central Nervous System Diseases (33) · Epilepsy (21) · Neurologic Manifestations (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Mental Disorders (3) · Dementia (2) · Epileptic Syndromes (2) · Neurocognitive Disorders (2) · Neurodegenerative Diseases (2) · Tauopathies (2) · Acid-Base Imbalance (1) · Acidosis (1)
Transcranial Direct Current Stimulation (2) · Bumetanide (1) · Clioquinol (1) · Probiotics (1) · Transcranial Magnetic Stimulation (1) · mycophenolic adenine dinucleotide (1)
Cedars-Sinai Medical Center (4) · Duke University (3) · NeuroPro Therapeutics, Inc. (2) · University of Pennsylvania (2) · Aaron Boes (1) · Boston Children's Hospital (1) · Boston University Charles River Campus (1) · Brain Sentinel (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · IRCCS Eugenio Medea (1) · Institute of Child Health (1) · KU Leuven (1) · María Gómez Eguílaz (1) · Mazandaran University of Medical Sciences (1) · PhytoTech Therapeutics, Ltd. (1)
United States (18) · France (2) · Iran (2) · Switzerland (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Canada (1) · China (1) · Czechia (1) · Denmark (1) · Germany (1) · Israel (1)
Adam Mamelak, MD (4) · Ueli Rutishauser, PhD (4) · Birgit Frauscher, MD PD (3) · Aaron Boes, MD, PhD (1) · Alexander Rotenberg, MD, PhD (1) · Alexandra Astner-Rohracher (1) · Andrey A Zuev, MD, PhD (1) · Angela V Price, M.D. (1) · Frans Leijten, MD, PhD (1) · Jason Hauptman, MD, PhD (1) · Jeffrey G Ojemann, MD (1) · John O'Doherty, PhD (1) · Josef Parvizi, MD, PhD (1) · Kathryn A Davis, MD, MSTR (1) · Kathryn Lightfoot (1)
PMID 29062105, PMID 30198325, PMID 34541534, PMID 35770134, PMID 39175939, PMID 39530262
R00NS126715 (1), R01MH133729 (1), R01MH134990 (1), R01NS106611 (1), R21MH120441 (1), R61DC022835 (1), U01NS113198 (1), U01NS117839 (1)