7 completed. 7 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 7 |
Follow Endotoxemia: new trials by email Literature Review of Endotoxemia trials Research Report on Endotoxemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PK/PD of EA-230 During Endotoxemia EA-230, Endotoxin, Placebo - Endotoxemia, Systemic Inflammatory Response | Phase 1 | Completed | Radboud University Medical Center | 60 | 2015-02-01 | 2016-06-23 |
| A Possible Therapeutic Role for Adenosine During Inflammation AMPD1 polymorphism, Caffeine infusion, placebo - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 33 | 2007-08-01 | 2009-10-01 |
| Anti-Inflammatory Effect of Statins in the Human Endotoxin Model LPS 2ng/kg intravenous bolus, Simvastatin 80mg; administered daily p.o. over 5 days, Rosuvastatin 40mg; administered daily p.o. over 5 days - Endotoxemia | Phase 1 | Completed | Medical University of Vienna | 6 | 2006-03-01 | 2007-01-05 |
| Ethnic Differences in the Inflammatory Response in Systemic Inflammation LPS - Endotoxemia | Phase 1 | Completed | Medical University of Vienna | 32 | 2006-01-01 | 2006-09-13 |
| Pathophysiology and Clinical Relevance of Endotoxin Tolerance in Humans repeated injections of endotoxin during 5 days - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 16 | 2005-10-01 | 2008-04-15 |
| Effect of Selective iNOS Inhibition During Human Endotoxemia Aminoguanidine, endotoxin - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 7 | 2005-01-01 | 2008-04-15 |
| Blockade of Vascular Potassium Channels During Human Endotoxemia endotoxin, Potassium channel blockers: TEA, Quinin, Tolbutamide, L-NMMA - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 36 | 2003-01-01 | 2008-10-17 |
Inflammation (1)
Bacteremia (7) · Infections (7) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Sepsis (7) · Systemic Inflammatory Response Syndrome (7) · Toxemia (7) · Inflammation (6)
Endotoxins (3) · Lipopolysaccharides (2) · Tolbutamide (1) · alanyl-glutaminyl-glycyl-valine (1) · omega-N-Methylarginine (1) · pimagedine (1)
Radboud University Medical Center (5) · Medical University of Vienna (2)
Netherlands (4) · Austria (2)
Christa Firbas, MD (1) · Michael Wolzt, MD (1) · P Pickkers, MD, Prof. (1) · Peter Pickkers, MD PhD (1) · Peter Pickkers, MD, PhD (1) · Peter Pickkers, MD,PhD (1) · Peter Pickkers, PhD (1)
PMID 16864730, PMID 18433844, PMID 20444270, PMID 21211004, PMID 30919998