4 completed, 2 unknown, 1 terminated. 7 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Completed 4, Unknown 2, Terminated 1 |
Follow Endotoxemia: new trials by email Literature Review of Endotoxemia trials Research Report on Endotoxemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes Rifaximin, Placebo - Liver Cirrhosis, Coagulation Disorder | Phase 4 | Terminated | University of Roma La Sapienza | 20 | 2021-04-03 | 2024-10-08 |
| Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide Defibrotide, Placebo (0.9% sodium chloride), Lipopolysaccharide - Healthy Volunteers, Endotoxemia | Phase 4 | Completed | Bernd Jilma | 20 | 2017-04-18 | 2019-12-19 |
| Vorapaxar in the Human Endotoxemia Model Vorapaxar, Placebo, LPS - Healthy Volunteers | Phase 4 | Completed | Medical University of Vienna | 16 | 2016-06-01 | 2020-01-10 |
| Effects of Vasopressors on Immune Response Norepinephrine, Phenylephrine, Vasopressins - Endotoxemia | Phase 4 | Completed | Radboud University Medical Center | 40 | 2016-01-01 | 2016-10-13 |
| Rifaximin Predicts the Complications of Decompensated Cirrhosis rifaximin - Cirrhosis | Phase 4 | Unknown | Shanghai Changzheng Hospital | 250 | 2013-10-01 | 2014-02-28 |
| The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia Dipyridamole, Placebo, LPS - Endotoxemia | Phase 4 | Completed | Radboud University Medical Center | 30 | 2010-03-01 | 2010-11-05 |
Inflammation (2) · Blood Platelet Disorders (1) · Diabetes Insipidus (1) · Fibrosis (1) · Hemostatic Disorders (1) · Liver Cirrhosis (1) · Neuroinflammatory Diseases (1) · Sepsis (1) · Thrombosis (1)
Bacteremia (7) · Infections (7) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Systemic Inflammatory Response Syndrome (7) · Toxemia (7) · Sepsis (6) · Inflammation (5) · Cardiovascular Diseases (2) · Vascular Diseases (2) · Digestive System Diseases (1) · Embolism and Thrombosis (1) · Endocrine System Diseases (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1)
Lipopolysaccharides (3) · Rifaximin (2) · Sodium Chloride (2) · Arginine Vasopressin (1) · Dexamethasone (1) · Dipyridamole (1) · Endotoxins (1) · Interleukin 1 Receptor Antagonist Protein (1) · Norepinephrine (1) · Phenylephrine (1) · Vasopressins (1) · defibrotide (1) · tocilizumab (1) · vorapaxar (1)
Radboud University Medical Center (3) · Bernd Jilma (1) · Medical University of Vienna (1) · Shanghai Changzheng Hospital (1) · University of Roma La Sapienza (1)
Netherlands (3) · Austria (2) · China (1) · Italy (1)
Bernd Jilma, MD (2) · Bart P Ramakers, MD (1) · Lucia Stefanini, Prof. (1) · Manuela Merli, Prof. (1) · Oliviero Riggio, Prof. (1) · Roberto Carnevale, Prof. (1) · Roeland Stolk, MD (1) · Wei-Fen Xie, MD (1)
PMID 22129171, PMID 31008870, PMID 33483132
2023 (1)