24 completed, 15 unknown, 3 terminated, 2 recruiting. 10 Phase 2, 9 Phase 1, 6 Not applicable, 6 Phase 4, 2 Phase 3.
Follow Drug Toxicity: new trials by email Literature Review of Drug Toxicity trials Research Report on Drug Toxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Real World Asparaginase Therapy Toxicity Drug Toxicity | Not yet recruiting | St. Jude Children's Research Hospital | 200 | 2026-11-01 | 2026-10-22 | |
| Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity Acetaminophen and Nicotinamide Riboside, Acetaminophen - Drug Toxicity | Phase 1 | Completed | University of South Alabama | 26 | 2024-01-15 | 2026-04-06 |
| Role of N-Acetylcysteine for Prevention of Cisplatin-induced Nephrotoxicity N-Acetylcysteine, Chemotherapy - Drug Toxicity | Not applicable | Unknown | Foundation University Islamabad | 70 | 2023-08-09 | 2023-08-31 |
| A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP) Acute Kidney Injury, Drug Use | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 4200 | 2023-08-01 | 2023-05-09 | |
| Optimizing Vancomycin Therapy in Children Sepsis, Critical Illness | Completed | Children's Hospital of Philadelphia | 29 | 2022-12-12 | 2024-12-20 | |
| Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia ALL, Childhood, Pediatric Cancer | Recruiting | University of Geneva, Switzerland | 556 | 2022-12-01 | 2026-01-15 | |
| ASSIST: A Surveillance Study of Illicit Substance Toxicity Surplus sample toxicology analysis - Overdose, Drug, Drug Use | Unknown | NHS Greater Glasgow and Clyde | 1000 | 2022-08-19 | 2022-09-19 | |
| Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After Lobectomy Breztri Aerosphere, Placebo - Lung Cancer, Nonsmall Cell, Perioperative | Not applicable | Unknown | Jianxing He | 128 | 2022-08-01 | 2022-07-25 |
| Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate High-dose methotrexate, Glucarpidase - Acute Kidney Injury, Drug Toxicity | Unknown | Protherics Medicines Development Limited | 1000 | 2022-04-01 | 2024-05-10 | |
| The Influence of Tramadol on Platelet Function Tramadol - Drug Toxicity, Platelet Dysfunction | Phase 4 | Completed | Medical University of Graz | 33 | 2022-01-26 | 2024-01-18 |
| Atrial Fibrillation in Active Cancer Patients occurence of atrial fibrillation - Cancer, Drug Toxicity | Unknown | University Hospital, Caen | 1000 | 2021-09-01 | 2024-08-09 | |
| Efficacy and Safety of Expanded UCMSCs On Patients With Moderate to Severe Psoriasis Umbilical cord mesenchymal stem cells - Mesenchymal Stromal Cells, Psoriasis | Phase 1 / Phase 2 | Unknown | Guangdong Provincial Hospital of Traditional Chinese Medicine | 5 | 2021-08-31 | 2021-02-09 |
| Reduction of MTX Levels After Glucarpidase Treatment in DLBCL Patients at Risk of CNS Glucarpidase 1000 UNT [Voraxaze] - Diffuse Large B-Cell Lymphoma, Drug Toxicity | Phase 2 | Terminated | Fundacion CRIS de Investigación para Vencer el Cáncer | 3 | 2021-07-19 | 2024-05-13 |
| Antidote for Valproic Acid Toxicity: a New Indication for Meropenem Antibiotic. Meropenem Injection - Drug Toxicity | Phase 4 | Unknown | Mabaret Al-Asafara Hospitals | 48 | 2021-06-01 | 2020-12-17 |
| Evaluation of Drug Overdose Poisoning Cases and Indications for ICU Admission Drug Toxicity - Drug Toxicity | Unknown | Assiut University | 100 | 2021-04-01 | 2021-08-03 | |
| Adverse Effects of Ivermectin Used in Egypt During COVID-19 Ivermectin - Covid19, Ivermectin Poisoning | Unknown | Menoufia University | 200 | 2021-02-03 | 2021-02-10 | |
| TDM for Optimized Outcome in Patients With mRCC. Measurement of concentration of active metabolite in cancer treatment. - Kidney Cancer, Renal Cell Carcinoma Metastatic | Recruiting | Niels Fristrup | 200 | 2020-11-01 | 2026-05-04 | |
| Infliximab for Treatment of Immune Checkpoint Inhibitor Colitis Infliximab, Methylprednisolone, Prednisone - Melanoma Stage III, Melanoma Stage IV | Phase 2 | Active not recruiting | Massachusetts General Hospital | 42 | 2020-08-31 | 2026-10-29 |
| Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment and PSORI-CM01 Granule in Psoriasis Patients Calcipotriol ointment, PSORI-CM01 Granule, adipose-derived multipotent mesenchymal stem cells - Mesenchymal Stromal Cells, Psoriasis | Not applicable | Completed | Guangdong Provincial Hospital of Traditional Chinese Medicine | 8 | 2020-04-01 | 2023-08-24 |
| MW151-101: First-in-human Study of MW151 Placebo, MW151, 10mg, MW151, 20mg - Drug Toxicity | Phase 1 | Completed | Linda Van Eldik | 40 | 2019-10-22 | 2022-12-30 |
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Drug-Related Side Effects and Adverse Reactions (47) · Psoriasis (4) · Neoplasms (3) · Acute Kidney Injury (2) · Atrial Fibrillation (2) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Infections (2) · Neurotoxicity Syndromes (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Amyloidosis (1) · Anemia (1) · Antiphospholipid Syndrome (1) · Anxiety Disorders (1) · Blood Coagulation Disorders (1)
Chemically-Induced Disorders (47) · Neoplasms (12) · Pathological Conditions, Signs and Symptoms (10) · Hemic and Lymphatic Diseases (8) · Neoplasms by Site (8) · Pathologic Processes (8) · Cardiovascular Diseases (7) · Neoplasms by Histologic Type (7) · Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (6) · Hematologic Diseases (6) · Urogenital Diseases (6) · Female Urogenital Diseases (5) · Heart Diseases (5)
Acetaminophen (2) · Methotrexate (2) · glucarpidase (2) · 2-(4-(4-methyl-6-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine (1) · Acetylcysteine (1) · Blood Specimen Collection (1) · Brachytherapy (1) · CTLA-4 Antigen (1) · Cisplatin (1) · Drug Combinations (1) · Drug Therapy (1) · Epoetin Alfa (1) · Erlotinib Hydrochloride (1) · Erythropoietin (1) · Fluid Therapy (1)
Guangdong Provincial Hospital of Traditional Chinese Medicine (4) · Groupe Hospitalier Pitie-Salpetriere (2) · Massachusetts General Hospital (2) · Amgen (1) · Anhui Medical University (1) · Arkansas Children's Hospital Research Institute (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Barretos Cancer Hospital (1) · Children's Hospital of Philadelphia (1) · Consorci Sanitari de l'Anoia (1) · Denver Health and Hospital Authority (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Foundation University Islamabad (1) · Fundacion CRIS de Investigación para Vencer el Cáncer (1)
United States (15) · China (6) · France (5) · Egypt (3) · Italy (3) · Spain (3) · Denmark (2) · Austria (1) · Brazil (1) · India (1) · Norway (1) · Pakistan (1) · South Korea (1) · United Kingdom (1)
Chuanjian Lu, PhD (2) · Adolfo De la Fuente, PD (1) · Alain Manrique, MD (1) · Brian M Everist, MD (1) · Carmelo Rizzari, MD (1) · Cesar Serrano, MD (1) · Christopher Newton-Cheh, MD, MPH (1) · Chuanjian Lu (1) · David J Lowe, MBChB BMSc FRCEM (1) · Giacomo Cavallaro, MD, PhD (1) · Gillian Thomas (1)
PMID 10103341, PMID 10586010, PMID 11981287, PMID 15255031, PMID 16374442, PMID 16816511, PMID 17036033, PMID 19401528, PMID 20368313, PMID 20836739, PMID 21178824, PMID 21496529, PMID 21636639, PMID 21646940, PMID 21784446, PMID 21809002, PMID 22206744, PMID 22424940, PMID 22532328, PMID 22875659, PMID 23149172, PMID 23224224, PMID 23592318, PMID 23669525, PMID 24022367, PMID 24168068, PMID 24296799, PMID 24607244, PMID 24623338, PMID 25047090, PMID 25155722, PMID 25280497, PMID 25808019, PMID 26169430, PMID 27486571, PMID 27490643, PMID 27815401, PMID 27943125, PMID 29475179, PMID 29732396, PMID 30608563, PMID 31023257, PMID 31249952, PMID 31761141, PMID 32015090, PMID 32138284, PMID 32481505, PMID 32818481, PMID 34988162, PMID 35114404
2017 (1), K23HD091365 (1), P30CA076292 (1), R01AG061898 (1), R01HL143070 (1), U10CA027469 (1)