9 completed, 3 recruiting, 2 not yet recruiting, 2 unknown. 16 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 9, Recruiting 3, Not yet recruiting 2, Unknown 2 |
| Phase 2 | 5 | Completed 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow Diphtheria: new trials by email Literature Review of Diphtheria trials Research Report on Diphtheria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine+Inactivated Poliomyelitis Vaccine Made From Sabin Strains - Diphtheria, Pertussis | Phase 1 / Phase 2 | Recruiting | Institute of Medical Biology, Chinese Academy of Medical Sciences | 380 | 2026-10-11 | 2026-10-23 |
| A Phase I Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents) Tdap vaccine - Pertussis (Whooping Cough), Diphtheria | Phase 1 | Not yet recruiting | Changchun BCHT Biotechnology Co. | 96 | 2026-04-20 | 2026-03-25 |
| Phase I/II Clinical Trial of Diphtheria-Tetanus-Pertussis (Reduced Dose) Vaccine low-dose Tetanus, Diphtheria and Acellular Component Pertussis Vaccine Adsorbed (Reduced Antigens Content), high-dose Tetanus, Diphtheria and Acellular Component Pertussis Vaccine Adsorbed (Reduced Antigens Content), Tetanus, Diphtheria and Acellular Pertussis Vaccine - Tetanus, Diphtheria and Acellular Pertussis Vaccination, Tetanus | Phase 1 / Phase 2 | Not yet recruiting | Institute of Medical Biology, Chinese Academy of Medical Sciences | 660 | 2026-03-12 | 2026-02-18 |
| Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined Vaccine Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis-Haemophilus influenzae type b (Conjugate)-Meningococcal Group ACYW135 (Conjugate) Combined Vaccine (DTcP-Hib-MCV4), DTcP-Hib-MCV4, Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis (DTcP) - Diphtheria, Tetanus and Acellular Pertussis, Epidemic Meningitis | Phase 1 | Recruiting | CanSino Biologics Inc. | 260 | 2025-12-19 | 2025-12-31 |
| Phase I Clinical Trial of Diphtheria-Tetanus-acellular Pertussis Component Combined Vaccine DTacP (one-dose booster), DTacP (three-dose primary vaccination), DT (one-dose booster) - Diphtheria, Tetanus | Phase 1 | Recruiting | Institute of Medical Biology, Chinese Academy of Medical Sciences | 460 | 2023-12-23 | 2024-01-03 |
| A Clinical Trial of Adsorbed Cell-free DPT Vaccine (5-component) (for People Aged 6 Years and Above) Tetanus, Reduced Diphtheria and Acellular Pertussis (Five Components) Combined Vaccine, Adsorbed (Aged 6 Years and Older) (Tdcp), 23-Valent Pneumococcal Polysaccharide Vaccine（PPV23）, Diphtheria and Tetanus Combined Vaccine, Adsorbed (DT) - Diphtheria, Tetanus | Phase 1 | Completed | CanSino Biologics Inc. | 180 | 2023-12-06 | 2026-08-07 |
| A Study to Evaluate Safety and Immunogenicity of APV006 in Healthy Adults DTaP-HepB-IPV-Hib vaccine - Diphtheria, Tetanus | Phase 1 | Unknown | LG Chem | 42 | 2023-07-17 | 2023-07-19 |
| Phase I Clinical Trial of Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed . Diphtheria,Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed, Diphtheria and Tetanus Combined Vaccine, Adsorbed, Diphtheria-tetanus-acellular pertussis vaccine - Diphtheria, Tetanus | Phase 1 | Completed | CanSino Biologics Inc. | 400 | 2020-04-28 | 2022-10-31 |
| Evaluate the Safety Pharmacokinetics of a Human Monoclonal Antibody S315 Against Diphtheria Toxin in Healthy Subjects S315, 0.9% Sodium Chloride (NaCl) - Diphtheria | Phase 1 | Completed | MassBiologics | 41 | 2019-04-23 | 2020-02-05 |
| A Study to Compare LBVD to Eupenta and Imovax Polio in Healthy Adults DTP-HepB-IPV-Hib vaccine, DTP-HepB-Hib vaccine & IPV - Diphtheria, Tetanus | Phase 1 | Completed | LG Chem | 42 | 2017-07-03 | 2019-08-29 |
| Safety and Immunogenicity Study of Tetanus, Diphtheria and Acellular Pertussis (Tdap) Vaccine Biological: GC3111 vaccine, Biological: Boostrix® vaccine - Tetanus, Diphtheria | Phase 1 / Phase 2 | Unknown | Green Cross Corporation | 220 | 2016-06-01 | 2016-11-07 |
| Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed Formulation 1, Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed, Formulation 2, Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed, Formulation 3 - Tetanus, Diphtheria | Phase 1 / Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 1363 | 2015-10-22 | 2022-03-23 |
| Study of the Tdap Combined Vaccine (ADACEL™) as a Booster Dose in Healthy Adults and Children in China Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed Tdap - Diphtheria, Tetanus | Phase 1 | Completed | Sanofi Pasteur, a Sanofi Company | 40 | 2013-08-01 | 2016-03-07 |
| Study of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine (ADACEL®) as a Booster in Adolescents (ADACEL®): Tetanus, Reduced Diphtheria Toxoid and Acellular Pertussis - Pertussis, Tetanus | Phase 1 / Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 43 | 2012-09-01 | 2014-02-21 |
| Safety and Dose Ranging Study of Acellular Pertussis and Acellular Pertussis -Tetanus-Diphtheria Booster Vaccines in Healthy Adults Ages 18 to 40 Years Acellular pertussis vaccine, Tetanus, reduced diphtheria, and acellular pertussis vaccine (adsorbed), Licensed TdaP booster vaccine - Pertussis, Whooping Cough | Phase 1 | Completed | Novartis Vaccines | 420 | 2012-03-01 | 2016-04-04 |
| Pertussis Vaccine in Healthy Pregnant Women Placebo, Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed - Diphtheria, Pertussis | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 80 | 2009-01-01 | 2014-07-25 |
Tetanus (15) · Whooping Cough (14) · Haemophilus Infections (3) · Poliomyelitis (3) · Hepatitis B (2) · Infections (1) · Meningitis, Meningococcal (1) · Trismus (1)
Actinomycetales Infections (16) · Bacterial Infections (16) · Bacterial Infections and Mycoses (16) · Corynebacterium Infections (16) · Gram-Positive Bacterial Infections (16) · Clostridium Infections (15) · Gram-Negative Bacterial Infections (15) · Infections (15) · Bordetella Infections (14) · Respiratory Tract Diseases (14) · Respiratory Tract Infections (14) · Nervous System Diseases (5) · Central Nervous System Diseases (4) · Central Nervous System Infections (4) · Neuroinflammatory Diseases (4)
Tetanus Toxoid (8) · Vaccines, Combined (3) · Diphtheria-Tetanus-acellular Pertussis Vaccines (2) · Saline Solution (2) · Sodium Chloride (2) · adacel (2) · 23-valent pneumococcal capsular polysaccharide vaccine (1) · Aging (1) · Boostrix (1) · Immunization, Secondary (1) · Pentavac (1) · Poliovirus Vaccine, Inactivated (1)
CanSino Biologics Inc. (3) · Institute of Medical Biology, Chinese Academy of Medical Sciences (3) · Sanofi Pasteur, a Sanofi Company (3) · LG Chem (2) · Changchun BCHT Biotechnology Co. (1) · Green Cross Corporation (1) · MassBiologics (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Novartis Vaccines (1)
China (7) · United States (3) · South Korea (2) · Belgium (1) · Japan (1)
Geert Leroux-Roels, Prof. Dr. (1) · Jiawei Xu (1) · Nam Joong Kim (1) · Ronald Goldwater, MD (1) · WJ Kim (1) · Wang Yanxia (1) · Wenge Tang (1) · Yanxia Wang (1)