1305 completed, 549 unknown, 203 terminated, 149 recruiting. 2464 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 2464 | Completed 1305, Unknown 549, Terminated 203, Recruiting 149, Withdrawn 106, Not yet recruiting 97, Active not recruiting 42, Enrolling by invitation 10, Suspended 3 |
Follow Digestive System Diseases: new trials by email Literature Review of Digestive System Diseases trials Research Report on Digestive System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis High dose budesonide rectal foam, Low dose budesonide rectal foam, Matching placebo rectal foam - Ulcerative Colitis | Phase 4 | Not yet recruiting | Bausch Health Americas, Inc. | 100 | 2029-06-01 | 2026-10-06 |
| ASAPP Study - Topical 5-ASA as Prophylaxis for Pouchitis in Ulcerative Colitis Patients After Pelvic Pouch Surgery 5-ASA, Placebo - Ulcerative Colitis (UC), Pouchitis | Phase 4 | Not yet recruiting | University Hospital, Linkoeping | 110 | 2027-04-01 | 2026-08-19 |
| Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study Irrigation with PVI, Usual care - Acute, Perforated Appendicitis | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 1750 | 2027-03-01 | 2025-02-10 |
| Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health. Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy - Hepatitis B, Human Papilloma Virus | Phase 4 | Not yet recruiting | Eunice Dube | 2140 | 2027-01-30 | 2026-07-30 |
| Combating Related Epidemics in HCV Cepheid GeneXpert HCV Test, Abbott Determine HIV - 1/2 Ag/Ab, Abbott Determine HbsAg 2 - HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV) | Phase 4 | Not yet recruiting | Duke University | 1280 | 2027-01-20 | 2026-10-15 |
| Safety and Efficacy of a STOPping Strategy Versus Classical Maintenance Dose of JAK Inhibitors in Deep Remission Patients With Ulcerative Colitis treatment withdrawal - Ulcerative Colitis in Remission | Phase 4 | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 224 | 2027-01-01 | 2026-07-22 |
| B-Ensure: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants Bepirovirsen - Hepatitis B | Phase 4 | Not yet recruiting | GlaxoSmithKline | 303 | 2026-12-03 | 2026-11-02 |
| AI-Powered Hepatitis C Single-Encounter Test-and-Treat Epclusa (sofosbuvir and velpatasvir) - HEPATITIS C (HCV) | Phase 4 | Not yet recruiting | Patrick Grace | 35 | 2026-12-01 | 2026-08-28 |
| MIRICURE: Mirikizumab With Curettage and Repair (Closure) for Perianal Fistulizing Crohn's Disease Mirikizumab, Fistula Tract Curettage and Closure - Crohn's Disease, Perianal Fistula | Phase 4 | Not yet recruiting | Icahn School of Medicine at Mount Sinai | 50 | 2026-12-01 | 2026-08-24 |
| FirST Lines of Biologics in pAtients With ulceRaTivE Colitis: a Randomised Controlled Trial 1: infliximab 2: filgotinib 3: ustekinumab 4: vedolizumab, 1: ustekinumab 2: vedolizumab 3: infliximab 4: filgotinib, 1: vedolizumab 2: infliximab 3: filgotinib 4: ustekinumab - Ulcerative Colitis (UC) | Phase 4 | Not yet recruiting | University Hospital, Clermont-Ferrand | 240 | 2026-12-01 | 2026-10-21 |
| A Study of Zolbetuximab Given With mFOLFOX6 or CAPOX Chemotherapy in Indian Adults With Gastric Cancer Zolbetuximab, Oxaliplatin, Folinic Acid - Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer | Phase 4 | Not yet recruiting | Astellas Pharma Global Development, Inc. | 50 | 2026-11-30 | 2026-09-21 |
| Efficacy of Upadacitinib Re-induction Therapy in Patients With Ulcerative Colitis Who Lost Response to 30 mg Maintenance Dose Upadacitinib - Ulcerative Colitis (UC) | Phase 4 | Not yet recruiting | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives | 100 | 2026-11-15 | 2026-10-29 |
| Varenicline for Smoking Cessation in Pancreatitis Varenicline (VAR) - Pancreatitis, Chronic Pancreatitis | Phase 4 | Not yet recruiting | Mayo Clinic | 45 | 2026-11-13 | 2026-10-19 |
| Tucatinib Continuation Study tucatinib - HER2-positive Breast Cancer, Cervical Cancer | Phase 4 | Not yet recruiting | Pfizer | 175 | 2026-11-06 | 2026-08-28 |
| A Trial of Pembrolizumab With Chemotherapy or Chemoradiotherapy in Participants From India With Different Types of Cancer (MK-3475-G44/KEYNOTE-G44) Pembrolizumab, Cisplatin, 5-Fluorouracil - Neoplasm Malignant, Gastric Neoplasms | Phase 4 | Not yet recruiting | Merck Sharp & Dohme LLC | 150 | 2026-11-06 | 2026-09-03 |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy Labetalol, Magnesium Sulfate, Lidocaine - Postoperative Pain, Cholelithiasis | Phase 4 | Not yet recruiting | Assiut University | 90 | 2026-11-01 | 2026-10-08 |
| Vonoprazan High-Dose Dual VS Levofloxacin Concomitant Vonoprazan, Levofloxacin 500mg - Helicobacter Pylori Infection, Peptic Ulcer Disease | Phase 4 | Not yet recruiting | Damascus Hospital | 150 | 2026-11-01 | 2026-06-03 |
| Iron Repletion in Cystic Fibrosis IV Repletion, PO Repletion - Cystic Fibrosis, Iron Deficiencies | Phase 4 | Not yet recruiting | University of Michigan | 100 | 2026-11-01 | 2026-10-29 |
| Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity Placebo, Tirzepatide - Obese Adults | Phase 4 | Not yet recruiting | Mayo Clinic | 30 | 2026-10-26 | 2026-10-26 |
Showing 20 of 2464. Sign in to see all of them.
Hepatitis B, Chronic (190) · Hepatitis C (184) · Hepatitis B (174) · Crohn Disease (150) · Hepatitis C, Chronic (144) · Colitis, Ulcerative (127) · Gastroesophageal Reflux (116) · Colorectal Neoplasms (106) · Carcinoma, Hepatocellular (105) · Cystic Fibrosis (88) · Liver Cirrhosis (88) · Inflammatory Bowel Diseases (80) · Non-alcoholic Fatty Liver Disease (80) · Fibrosis (69) · Stomach Neoplasms (66)
Gastrointestinal Diseases (1090) · Liver Diseases (1050) · Pathological Conditions, Signs and Symptoms (916) · Infections (773) · Pathologic Processes (736) · Intestinal Diseases (708) · Virus Diseases (665) · Hepatitis (657) · Hepatitis, Viral, Human (652) · Blood-Borne Infections (633) · Communicable Diseases (632) · Neoplasms (444) · Neoplasms by Site (421) · Digestive System Neoplasms (417)
Ribavirin (140) · peginterferon alfa-2a (126) · entecavir (74) · Esomeprazole (64) · Tenofovir (56) · Infliximab (42) · Sofosbuvir (42) · Lamivudine (36) · Omeprazole (36) · peginterferon alfa-2b (34) · vedolizumab (32) · Lansoprazole (28) · Telbivudine (27) · Metronidazole (26) · sofosbuvir-velpatasvir drug combination (26)
Hoffmann-La Roche (54) · GlaxoSmithKline (51) · National Taiwan University Hospital (31) · AstraZeneca (27) · Sun Yat-sen University (23) · Takeda (23) · Merck Sharp & Dohme LLC (22) · Yonsei University (22) · Novartis Pharmaceuticals (20) · Mayo Clinic (19) · Universitaire Ziekenhuizen KU Leuven (17) · Asan Medical Center (16) · Kaohsiung Medical University Chung-Ho Memorial Hospital (15) · Taipei Veterans General Hospital, Taiwan (15) · Third Affiliated Hospital, Sun Yat-Sen University (15)
United States (547) · China (362) · South Korea (158) · Taiwan (118) · Canada (117) · Spain (102) · Italy (97) · Germany (90) · France (88) · Belgium (74) · Netherlands (74) · United Kingdom (74) · Denmark (62) · Egypt (56) · Australia (48)
Chen-Hua Liu, MD (9) · Paula Fernstrom (8) · Arnulf Ferlitsch, MD (6) · Jia-Horng Kao, MD, PhD (6) · Shih-Jer Hsu, MD (6) · Arie Levine, MD (5)
PMID 32710245, PMID 37467180, PMID 24915612, PMID 25018650, PMID 28404091, PMID 28404092, PMID 40013523, PMID 15470215, PMID 19187608, PMID 21182232, PMID 22436845, PMID 23046671, PMID 23518903, PMID 25348661, PMID 28427875, PMID 29405329, PMID 40357993, PMID 11668104, PMID 11981766, PMID 12049862, PMID 12091661, PMID 12540794, PMID 15014185, PMID 19052126, PMID 19208350, PMID 19729084, PMID 20009522, PMID 20049753, PMID 21366801, PMID 21910897, PMID 22045673, PMID 22508412, PMID 22777097, PMID 23152962, PMID 23732904, PMID 24508042, PMID 24954675, PMID 25190434, PMID 25478944, PMID 26026936, PMID 26190091, PMID 26453773, PMID 26867206, PMID 29696665, PMID 29960156, PMID 30237305, PMID 30552056, PMID 30576085, PMID 30689258, PMID 33293204
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