18 completed, 4 recruiting, 3 active not recruiting, 1 available. 14 Phase 2, 6 Phase 1, 3 Phase 3, 2 Not applicable, 1 Phase 4.
Follow Desmoid Tumor: new trials by email Literature Review of Desmoid Tumor trials Research Report on Desmoid Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient-reported Outcomes Following Percutaneous Ablation of Desmoid Tumors Desmoid tumor ablation - Desmoid Tumor, Aggressive Fibromatoses | Enrolling by invitation | Mayo Clinic | 30 | 2026-10-01 | 2026-09-29 | |
| A Study in Adults With Desmoid Tumors ES014 - Desmoid Tumor | Phase 2 | Recruiting | Elpiscience (Suzhou) Biopharma, Ltd. | 50 | 2026-04-24 | 2026-10-21 |
| Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) Nirogacestat - Desmoid Tumor, Aggressive Fibromatosis | Phase 4 | Recruiting | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 50 | 2025-09-17 | 2026-11-09 |
| A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) Nirogacestat oral tablet - Desmoid Tumor, Aggressive Fibromatosis | Phase 2 | Active not recruiting | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 20 | 2025-08-08 | 2026-09-15 |
| Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare) Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP) | Active not recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 1500 | 2024-05-13 | 2026-03-10 | |
| A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors radiofrequency ablation - Desmoid Tumor, Desmoid Fibromatosis | Not applicable | Not yet recruiting | Blokhin's Russian Cancer Research Center | 27 | 2024-04-01 | 2024-04-10 |
| Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting Cryoablation, Chemotherapy drug - Desmoid Tumor | Not applicable | Recruiting | University Hospital, Strasbourg, France | 150 | 2024-03-04 | 2025-11-19 |
| Burden of Disease and Living Situation in Desmoid Patients No Intervention - Desmoid Tumor, Quality of Life | Completed | Technische Universität Dresden | 100 | 2023-10-01 | 2025-08-24 | |
| Study of Cryoablation and Nirogacestat for Desmoid Tumor Nirogacestat, Cryoablation - Desmoid Tumor | Phase 2 | Recruiting | Nam Bui | 28 | 2023-08-15 | 2026-09-10 |
| A Study of AL102 in Patients With Progressing Desmoid Tumors AL102, Placebo - Desmoid, Desmoid Tumor | Phase 2 / Phase 3 | Active not recruiting | Immunome, Inc. | 198 | 2021-09-01 | 2026-06-08 |
| A Randomized, Double-blind,Phase Ⅲ Study of Liposome Doxorubicin in Desmoid Tumor Liposome doxorubicin, Saline Solution - Desmoid Tumor | Phase 3 | Unknown | Sun Yat-sen University | 72 | 2020-09-29 | 2022-09-30 |
| Quality of Life of Patients With Desmoid-type Fibromatosis Questionnaires - Desmoid Tumor, Desmoid-type Fibromatosis | Completed | Erasmus Medical Center | 156 | 2020-08-06 | 2023-09-07 | |
| Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) Nirogacestat oral tablet, Placebo Oral Tablet - Desmoid Tumor, Aggressive Fibromatosis | Phase 3 | Completed | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 142 | 2019-04-17 | 2026-08-20 |
| A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor vactosertib/imatinib combination - Desmoid Tumor | Phase 1 / Phase 2 | Completed | Hyo Song Kim | 24 | 2019-04-15 | 2024-05-13 |
| Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059 Tegavivint - Desmoid Tumor | Phase 1 | Completed | Iterion Therapeutics | 24 | 2018-07-15 | 2023-03-01 |
| Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers Nab-Rapamycin, Nivolumab - Ewing Sarcoma, PEComa | Phase 1 / Phase 2 | Completed | Sarcoma Oncology Research Center, LLC | 34 | 2017-08-24 | 2025-02-17 |
| Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas laboratory biomarker analysis - Childhood Alveolar Soft-part Sarcoma, Childhood Angiosarcoma | Completed | Children's Oncology Group | 70 | 2016-05-01 | 2016-05-17 | |
| MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors Magnetic Resonance High Intensity Focused Ultrasound - Relapsed Pediatric Solid Tumors, Refractory Pediatric Solid Tumors | Phase 1 | Completed | AeRang Kim | 7 | 2014-04-01 | 2025-01-01 |
| A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis Sirolimus - Desmoid Tumor | Phase 1 / Phase 2 | Completed | MaineHealth | 9 | 2014-02-01 | 2023-06-26 |
| CT-guided Radioactive Iodine-125 Seed Implantation for Recurrent Desmoid Tumors CT-guided radioactive iodine-125 seed implantation - Brachytherapy, Desmoid Tumor | Completed | Peking University Third Hospital | 38 | 2013-07-01 | 2024-01-08 |
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Desmoid Tumors (30) · Colorectal Neoplasms (3) · Sarcoma (3) · Carcinoma, Hepatocellular (2) · Chordoma (2) · Desmoplastic Small Round Cell Tumor (2) · Fibrosarcoma (2) · Gardner Syndrome (2) · Hemangiosarcoma (2) · Liposarcoma (2) · Malignant mesenchymal tumor (2) · Osteosarcoma (2) · Rhabdomyosarcoma (2) · Sarcoma, Ewing (2) · AIDS-related Kaposi sarcoma (1)
Fibroma (30) · Neoplasms by Histologic Type (30) · Neoplasms, Connective Tissue (30) · Neoplasms, Connective and Soft Tissue (30) · Neoplasms, Fibrous Tissue (30) · Neoplasms (29) · Neoplasms by Site (5) · Neoplasms, Glandular and Epithelial (5) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Colonic Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Gastrointestinal Diseases (3)
nirogacestat (6) · Cryosurgery (2) · Imatinib Mesylate (2) · Methotrexate (1) · Nivolumab (1) · Radiofrequency Ablation (1) · Radiotherapy (1) · Saline Solution (1) · Sirolimus (1) · Sulindac (1) · Sunitinib (1) · Surveys and Questionnaires (1) · Tamoxifen (1) · Toremifene (1) · Vinblastine (1)
SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany (4) · Children's Oncology Group (3) · Advocate Lutheran General Hospital (1) · AeRang Kim (1) · Blokhin's Russian Cancer Research Center (1) · Elpiscience (Suzhou) Biopharma, Ltd. (1) · Erasmus Medical Center (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Heidelberg University (1) · Hyo Song Kim (1) · Immunome, Inc. (1) · Iterion Therapeutics (1) · MaineHealth (1) · Mayo Clinic (1)
United States (15) · Germany (7) · Netherlands (5) · United Kingdom (5) · Belgium (4) · Italy (4) · Canada (3) · China (3) · France (3) · Australia (2) · Poland (2) · South Korea (2) · Spain (2) · Israel (1) · Japan (1)
Steve Skapek, MD (2) · Aaron R Weiss, DO (1) · AeRang Kim, MD, PhD (1) · Bernd Kasper, MD (1) · Bernd Kasper, PD Dr. med. (1) · Brian L. Samuels, MD (1) · Bruce Himelstein, MD (1) · C. Verhoef, MD, PhD (1) · Erlinda M Gordon, MD (1) · Hans P Simmen, MD (1) · Jean-Yves Blay, MD, PhD (1) · Junjie Wang, M.D. (1) · Marco Vitellaro, MD (1)
PMID 17290057, PMID 19451429, PMID 20622000, PMID 23114473, PMID 24089446, PMID 26861905, PMID 28282612, PMID 31401903, PMID 36884323, PMID 37347393, PMID 41115259
P30CA008748 (1), U10CA098543 (1)