27 completed, 12 recruiting, 6 terminated, 5 active not recruiting. 32 Phase 2, 22 Phase 1, 3 Early Phase 1, 2 Not applicable, 2 Phase 3.
Follow Desmoplastic Small Round Cell Tumor: new trials by email Literature Review of Desmoplastic Small Round Cell Tumor trials Research Report on Desmoplastic Small Round Cell Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT EWSR1 immunotherapy, Pembrolizumab - Ewing Sarcoma, Desmoplastic Small Round Cell Tumor | Phase 1 | Not yet recruiting | Rabi Hanna | 24 | 2026-10-01 | 2026-09-17 |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| Clinical Study in Adult and Young Adult Patients With Advanced Desmoplastic Small Round Cell Tumor (DSRCT) ISG-TULIPS Lurbinectedin, Irinotecan - Desmoplastic Small Round Cell Tumor | Phase 2 | Recruiting | Italian Sarcoma Group | 20 | 2025-11-21 | 2026-09-02 |
| IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) Tislelizumab+liposomal doxorubicin+ifosfamide - Soft Tissue Sarcomas, Angiosarcoma | Phase 2 | Recruiting | Fudan University | 45 | 2025-02-25 | 2026-01-08 |
| Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas PEEL-224, Temozolomide, Vincristine - Sarcoma, Sarcoma, Ewing | Phase 1 / Phase 2 | Recruiting | David S Shulman, MD | 63 | 2025-01-27 | 2026-02-19 |
| Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor Signifor - Desmoplastic Small Round Cell Tumor, Synovial Sarcoma | Phase 2 | Recruiting | University Hospital Heidelberg | 28 | 2024-12-19 | 2025-01-13 |
| Safety and Efficacy of CAR-T Cell Therapy for Relapsed/refractory Neuroblastoma and Desmoplastic Small Round Cell Tumors: a Single-arm, Open-label Trial. CART therapy - Neuroblastoma (NB), Desmoplastic Small Round Cell Tumor (DSRCT) | Phase 1 / Phase 2 | Recruiting | Sun Yat-Sen University Cancer Center | 10 | 2024-12-12 | 2025-02-26 |
| MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma MASCT-I, Doxorubicin, Ifosfamide - Leiomyosarcoma, Liposarcoma | Phase 2 | Recruiting | HRYZ Biotech Co. | 148 | 2024-02-21 | 2025-07-24 |
| Lurbinectedin in FET-Fused Tumors Lurbinectedin - Ewing Sarcoma, Desmoplastic Small Round Cell Tumor | Phase 1 / Phase 2 | Recruiting | Children's Hospital of Philadelphia | 63 | 2023-07-27 | 2026-09-02 |
| B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) Fludarabine, Cyclophosphamide, MESNA - Pediatric Solid Tumor, Osteosarcoma | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 48 | 2022-07-06 | 2026-05-19 |
| A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577) Seclidemstat - Ewing Sarcoma, Myxoid Liposarcoma | Phase 1 / Phase 2 | Unknown | Salarius Pharmaceuticals, LLC | 10 | 2022-01-15 | 2023-08-01 |
| Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors PBI-200 - Solid Tumor, Adult, Brain Tumor, Primary | Phase 1 | Terminated | Pyramid Biosciences | 29 | 2021-07-20 | 2024-03-28 |
| Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group Patient with Soft Tissue Sarcoma - Soft Tissue Sarcoma, Clear Cell Sarcoma | Not applicable | Recruiting | Institut Claudius Regaud | 400 | 2021-04-26 | 2026-02-10 |
| Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor Biospecimen Collection, Computed Tomography, Echocardiography Test - Desmoplastic Small Round Cell Tumor, Osteosarcoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 55 | 2021-03-08 | 2026-10-13 |
| Registry to Collect Health Information About Desmoplastic Small Round Cell Tumor Desmoplastic Small Round Cell Tumor | Recruiting | Memorial Sloan Kettering Cancer Center | 250 | 2020-12-22 | 2026-01-12 | |
| Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Etoposide - Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Phase 2 | Terminated | M.D. Anderson Cancer Center | 1 | 2020-08-19 | 2025-06-29 |
| B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ B7H3-EGFRt-DHFR, second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG, Pembrolizumab - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 68 | 2020-07-13 | 2026-04-28 |
| CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor Ramucirumab, Cyclophosphamide, Vinorelbine - Desmoplastic Small Round Cell Tumor | Phase 1 / Phase 2 | Completed | Eli Lilly and Company | 30 | 2020-01-22 | 2026-08-07 |
| Study of High Dose Intravenous (IV) Ascorbic Acid in Measurable Solid Tumor Disease Ascorbic acid (vitamin C) - Sarcoma, Adenocarcinoma | Phase 2 | Withdrawn | Situs Cancer Research Center | 2020-01-01 | 2025-05-18 | |
| Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients Cisplatin, Cytoreductive Surgery, Doxorubicin - Malignant Abdominal Neoplasm, Malignant Pelvic Neoplasm | Early Phase 1 | Terminated | Mayo Clinic | 2 | 2019-11-08 | 2025-02-20 |
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Sarcoma (41) · Rhabdomyosarcoma (21) · Osteosarcoma (19) · Neuroblastoma (16) · Neuroectodermal Tumors, Primitive, Peripheral (16) · Sarcoma, Ewing (14) · Fibrosarcoma (13) · Sarcoma, Synovial (13) · Wilms Tumor (13) · Hemangiosarcoma (12) · Liposarcoma (12) · Neurofibrosarcoma (12) · Ovarian Neoplasms (10) · Malignant mesenchymal tumor (9)
Neoplasms by Histologic Type (58) · Neoplasms, Connective and Soft Tissue (58) · Neoplasms (55) · Neoplasms, Connective Tissue (40) · Neoplasms, Nerve Tissue (31) · Neoplasms, Glandular and Epithelial (30) · Neoplasms, Bone Tissue (26) · Neoplasms, Germ Cell and Embryonal (25) · Neoplasms, Muscle Tissue (25) · Neuroectodermal Tumors (25) · Neoplasms by Site (24) · Neoplasms, Neuroepithelial (23) · Neuroectodermal Tumors, Primitive (23) · Urogenital Diseases (22) · Urogenital Neoplasms (22)
Cyclophosphamide (10) · Doxorubicin (9) · Etoposide (7) · Vincristine (7) · Ifosfamide (6) · Filgrastim (5) · Radiotherapy (4) · Brachytherapy (3) · Carboplatin (3) · Cisplatin (3) · Irinotecan (3) · Melphalan (3) · Peripheral Blood Stem Cell Transplantation (3) · Temozolomide (3) · Thiotepa (3)
Memorial Sloan Kettering Cancer Center (9) · National Cancer Institute (NCI) (6) · Children's Oncology Group (4) · M.D. Anderson Cancer Center (3) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Mayo Clinic (2) · Salarius Pharmaceuticals, LLC (2) · Seattle Children's Hospital (2) · Societe Internationale d'Oncologie Pediatrique (2) · St. Jude Children's Research Hospital (2) · Amgen (1) · Assaf-Harofeh Medical Center (1) · Cellectar Biosciences, Inc. (1) · Children's Hospital of Philadelphia (1) · Daiichi Sankyo (1)
United States (43) · France (5) · United Kingdom (5) · Australia (4) · Germany (4) · Spain (4) · Canada (3) · China (3) · Italy (3) · Belgium (2) · Denmark (2) · Netherlands (2) · Switzerland (2) · Austria (1) · Hong Kong (1)
Emily Slotkin, MD (4) · Brian H. Kushner, MD (3) · Andrea Hayes-Jordan, MD (2) · Kim Kramer, MD (2) · Annabel B.M. Foot (1) · Carola A. S. Arndt, MD (1) · Catherine Albert, MD (1) · Chris DeRenzo, MD (1) · Christophe Bergeron (1) · Christopher W Ryan (1) · Damon R Reed (1) · Daniela Katz, M.D (1)
PMID 31401903, PMID 19451429, PMID 20338746, PMID 20471824, PMID 21896345, PMID 22665534, PMID 25858498, PMID 28212684, PMID 33047248, PMID 36371226, PMID 39255444, PMID 40934647, PMID 42131734, PMID 7595741, PMID 8622067
P30CA008748 (3), U01CA069856 (2), 2009 (1), 2016 (1), 2018 (1), N01CM00071 (1), N01CM62206 (1), P30CA014599 (1), P30CA015083 (1), U10CA024507 (1), U10CA098543 (1), UG1CA189958 (1), UM1CA228823 (1)