30 completed, 7 terminated, 3 withdrawn, 1 not yet recruiting. 20 Phase 2, 18 Phase 1, 4 Phase 3, 3 Not applicable.
Follow AIDS-related Kaposi sarcoma: new trials by email Literature Review of AIDS-related Kaposi sarcoma trials Research Report on AIDS-related Kaposi sarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nirogacestat in Patients With Kaposi Sarcoma Biospecimen Collection, Chest Radiography, Computed Tomography - AIDS-Related Kaposi Sarcoma, Skin Kaposi Sarcoma | Phase 2 | Recruiting | AIDS Malignancy Consortium | 28 | 2026-10-13 | 2026-10-20 |
| Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma Pegylated liposomal doxorubicin, Paclitaxel - Kaposi Sarcoma, HIV-1-infection | Phase 3 | Not yet recruiting | AIDS Malignancy Consortium | 130 | 2026-09-01 | 2026-01-23 |
| Doxil/Caelyx BE Study DOXIL/CAELYX - Ovarian Cancer, AIDS-related Kaposi Sarcoma | Phase 1 | Completed | Baxter Healthcare Corporation | 36 | 2023-12-16 | 2025-06-05 |
| Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC Non-Interventional, Non-Interventional Follow-up - HIV-Associated Malignant Neoplasm, HIV Infections | Completed | AIDS Malignancy Consortium | 460 | 2023-07-25 | 2026-08-14 | |
| NT-I7 for Kaposi Sarcoma in Patients With or Without HIV Efineptakin alfa - AIDS-Related Kaposi Sarcoma, HIV Infection | Phase 1 | Terminated | Fred Hutchinson Cancer Center | 8 | 2022-05-23 | 2024-06-27 |
| Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi Enhanced package for AHD care - Opportunistic Infections, HIV-Related, Cryptococcal Infections | Not applicable | Completed | Elizabeth Glaser Pediatric AIDS Foundation | 700 | 2021-06-01 | 2026-09-10 |
| Evaluating Quality of Life in Patients With AIDS-Associated Kaposi Sarcoma Treated With Bleomycin and Vincristine Bleomycin Sulfate, Laboratory Biomarker Analysis, Quality-of-Life Assessment - AIDS-Related Kaposi Sarcoma, Human Immunodeficiency Virus 1 Positive | Completed | AIDS Malignancy Consortium | 10 | 2018-10-10 | 2026-02-11 | |
| Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma gamma secretase inhibitor PF-03084014, pharmacological study, laboratory biomarker analysis - AIDS-related Kaposi Sarcoma, HIV Infection | Phase 2 | Withdrawn | AIDS Malignancy Consortium | 2015-07-01 | 2015-07-23 | |
| A Study of Selumetinib in Patients With Kaposi's Sarcoma Selumetinib - AIDS-related Kaposi's Sarcoma | Phase 1 / Phase 2 | Terminated | Sheffield Teaching Hospitals NHS Foundation Trust | 19 | 2012-06-15 | 2019-02-20 |
| Lenalidomide in Treating Patients With AIDS-Associated Kaposi's Sarcoma Lenalidomide - AIDS-Related Kaposi Sarcoma, Recurrent Kaposi Sarcoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 38 | 2010-08-27 | 2022-02-08 |
| Bortezomib in Treating Patients With Relapsed or Refractory AIDS-Related Kaposi Sarcoma Bortezomib, Laboratory Biomarker Analysis, Questionnaire Administration - AIDS-Related Kaposi Sarcoma, HIV Infection | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2010-01-22 | 2018-02-20 |
| Sunitinib Malate in Treating East African Patients With Kaposi Sarcoma sunitinib malate, laboratory biomarker analysis, pharmacological study - AIDS-related Kaposi Sarcoma, Classic Kaposi Sarcoma | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2009-01-01 | 2014-05-05 | |
| PTC299 in Treating Patients With HIV-Related Kaposi Sarcoma VEGF inhibitor PTC299, gene expression analysis, polymerase chain reaction - Kaposi's Sarcoma | Phase 1 / Phase 2 | Terminated | AIDS Malignancy Consortium | 17 | 2008-09-01 | 2018-06-06 |
| Liposomal Daunorubicin in Treating Patients With HIV-Related Kaposi's Sarcoma liposomal daunorubicin citrate - Sarcoma | Phase 1 | Terminated | AIDS Malignancy Consortium | 14 | 2008-09-01 | 2015-04-29 |
| Detecting Anal and Genital Human Papillomavirus Infection and Squamous Intraepithelial Lesions in HIV-Positive Patients Enrolled in AIDS Cancer Clinical Trials polymerase chain reaction, cytology specimen collection procedure, histological technique - Aids-related Malignancies, Lymphoma | Completed | AIDS Malignancy Consortium | 47 | 2008-05-14 | 2020-08-10 | |
| Sirolimus in Treating Patients With HIV-Related Kaposi's Sarcoma sirolimus - Sarcoma | Phase 1 | Completed | AIDS Malignancy Consortium | 7 | 2007-10-01 | 2014-08-29 |
| A Pilot Study Of the Effects of Highly Active Antiretroviral Therapy on Kaposi's Sarcoma in Zimbabwe abacavir/3TC/zidovudine, abacavir /3TC plus ritonavir boosted lopinavir - AIDS-related Kaposi's Sarcoma | Phase 2 / Phase 3 | Completed | Parirenyatwa Hospital | 49 | 2007-06-01 | 2014-10-30 |
| Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas sunitinib malate - Adult Malignant Fibrous Histiocytoma of Bone, Desmoid Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 53 | 2007-04-01 | 2016-01-20 |
| Imatinib Mesylate in Treating Patients With HIV-Related Kaposi's Sarcoma imatinib mesylate - Sarcoma | Phase 2 | Completed | AIDS Malignancy Consortium | 30 | 2005-06-01 | 2018-06-06 |
| Valproic Acid in Treating Patients With Kaposi's Sarcoma valproic acid - Sarcoma | Not applicable | Completed | AIDS Malignancy Consortium | 19 | 2005-02-01 | 2014-08-29 |
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Sarcoma, Kaposi (30) · Sarcoma (24) · HIV Infections (8) · Osteosarcoma (6) · Acquired Immunodeficiency Syndrome (5) · Breast Neoplasms (5) · Chondrosarcoma (5) · Esthesioneuroblastoma, Olfactory (5) · Lymphoma (5) · Neoplasms (5) · Neuroectodermal Tumors, Primitive, Peripheral (5) · Ovarian Neoplasms (5) · Squamous Cell Carcinoma of Head and Neck (5) · Carcinoma, Non-Small-Cell Lung (4)
Neoplasms by Histologic Type (36) · Neoplasms, Connective and Soft Tissue (34) · Virus Diseases (34) · Infections (33) · DNA Virus Infections (31) · Neoplasms (31) · Herpesviridae Infections (30) · Neoplasms, Vascular Tissue (30) · Urogenital Diseases (19) · Genital Diseases (18) · Immune System Diseases (18) · Blood-Borne Infections (12) · Communicable Diseases (12) · Immunologic Deficiency Syndromes (12) · Lentivirus Infections (12)
Paclitaxel (4) · liposomal doxorubicin (4) · Daunorubicin (2) · Docetaxel (2) · Etoposide (2) · Filgrastim (2) · Polymerase Chain Reaction (2) · Semaxinib (2) · Sunitinib (2) · Thalidomide (2) · nirogacestat (2) · AZD 6244 (1) · Altretamine (1) · Amifostine (1) · Analgesia (1)
AIDS Malignancy Consortium (12) · National Cancer Institute (NCI) (12) · Case Comprehensive Cancer Center (2) · Eastern Cooperative Oncology Group (2) · Memorial Sloan Kettering Cancer Center (2) · Roswell Park Cancer Institute (2) · Baxter Healthcare Corporation (1) · Centro di Riferimento Oncologico - Aviano (1) · Dana-Farber Cancer Institute (1) · Dartmouth-Hitchcock Medical Center (1) · Elizabeth Glaser Pediatric AIDS Foundation (1) · Fred Hutchinson Cancer Center (1) · National Institutes of Health Clinical Center (CC) (1) · Parirenyatwa Hospital (1) · Pfizer (1)
United States (33) · Brazil (1) · India (1) · Italy (1) · Malawi (1) · Puerto Rico (1) · Tanzania (1) · United Kingdom (1) · Zimbabwe (1)
Dirk Dittmer, PhD (2) · Jamie Hayden Von Roenn, MD (2) · Lawrence P. Leichman, MD (2) · Lee Ratner (2) · Robert Yarchoan, MD (2) · Scot C. Remick, MD (2) · Susan E. Krown, MD (2) · Alison L. Hannah, MBBS (1) · Anna E Coghill, PhD, MPH (1) · Appolinaire Tiam, MBChB, MMed, PhD (1) · Ariela Noy, MD (1) · Barbara J. Klencke, MD (1) · Bruce Dezube (1) · David Straus, MD (1)
PMID 10893291, PMID 17846226, PMID 18224669, PMID 18470481, PMID 19451429, PMID 20407240, PMID 27002157, PMID 35247913, PMID 38041058, PMID 39915263, PMID 41286911
U01CA070019 (6), U01CA121947 (6), UM1CA121947 (4), P30CA043703 (2), U01CA062502 (2), P30AI036219 (1), P30CA006516 (1), P30CA008748 (1), P30CA023108 (1), U10CA021115 (1), UM1CA154967 (1)