6 completed, 4 unknown, 2 terminated, 1 recruiting. 14 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 6, Unknown 4, Terminated 2, Recruiting 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
Follow Delayed Graft Function: new trials by email Literature Review of Delayed Graft Function trials Research Report on Delayed Graft Function
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation Pegcetacoplan, Placebo - Delayed Graft Function, End Stage Renal Disease | Phase 3 | Withdrawn | Apellis Pharmaceuticals, Inc. | 2026-05-18 | 2026-09-02 | |
| Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation Ravulizumab, Placebo - Delayed Graft Function, DGF | Phase 3 | Recruiting | Alexion Pharmaceuticals, Inc. | 450 | 2025-05-19 | 2026-06-18 |
| Graft Acute Kidney Injury: Vitamin B3 to Facilitate Renal Recovery In the Early Life of a Transplant Nicotinamide treatment, Placebo treatment - Delayed Graft Function | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 204 | 2023-01-12 | 2024-07-10 |
| Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys Oxygen - Delayed Graft Function, Kidney Transplant; Complications | Phase 3 | Unknown | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 60 | 2022-03-20 | 2024-05-23 |
| Heme Arginate in Transplantation Study Heme Arginate 25 MG/ML, 0.9% Sodium-chloride - Renal Transplant Rejection, Renal Transplant Failure | Phase 3 | Terminated | University of Edinburgh | 47 | 2019-03-12 | 2025-11-17 |
| Better Evidence for Selecting Transplant Fluids Plasma-Lyte 148 (approx. pH 7.4) IV Infusion, 0.9% SODIUM CHLORIDE 9g/L injection BP - End Stage Kidney Disease, Delayed Graft Function | Phase 3 | Completed | The University of Queensland | 808 | 2018-01-26 | 2024-10-15 |
| Reduce the Severity of DGF in Recipients of a Deceased Donor Kidney ANG-3777, Placebo - Delayed Graft Function | Phase 3 | Unknown | Angion Biomedica Corp | 253 | 2016-03-01 | 2021-06-03 |
| QPI-1002 for Prevention of Delayed Graft Function in Recipients of an Older Donor Kidney Transplant QPI-1002, Placebo - Delayed Graft Function | Phase 3 | Completed | Quark Pharmaceuticals | 594 | 2016-03-01 | 2020-05-13 |
| Prevention of Delayed Graft Function Using Eculizumab Therapy (PROTECT Study) Eculizumab, Placebo - Delayed Graft Function | Phase 2 / Phase 3 | Completed | Alexion Pharmaceuticals, Inc. | 288 | 2014-08-21 | 2018-12-17 |
| A Pilot Study Comparing the Safety and Efficacy of Everolimus With Other Medicines in Recipients of ECD/DCD Kidneys Everolimus, Tacrolimus, Mycophenolate mofetil (MMF/MPA) - Delayed Graft Function | Phase 2 / Phase 3 | Terminated | Matthew Cooper | 25 | 2013-06-01 | 2019-04-26 |
| Study of the Effect of N-acetyl Cysteine on the Renal Graft Function Biomarkers (IL18, NGAL) N-acetyl Cysteine - Disorder Related to Renal Transplantation | Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 60 | 2011-04-01 | 2011-07-27 |
| Remote Ischemic Preconditioning In Abdominal Organ Transplantation RIPC by Inflation of Pneumatic Tourniquet - Kidney Disease, Liver Disease | Phase 3 | Completed | University of Medicine and Dentistry of New Jersey | 85 | 2009-04-01 | 2015-01-14 |
| Anti-T-Lymphocyte Globulin (ATG) in Renal Transplantation of Kidneys With a Non-Heart-Beating (NHB) Donor ATG Fresenius - Renal Transplant Patients, Recipients of a Kidney From a Non-Heart-Beating Donor | Phase 3 | Unknown | Radboud University Medical Center | 180 | 2008-01-01 | 2008-08-13 |
| N-acetyl-cysteine (NAC) and Kidney Graft Function N-acetylcysteine - Brain Death, Chronic Renal Insufficiency | Phase 3 | Completed | Institut d'Anesthesiologie des Alpes Maritimes | 236 | 2006-09-01 | 2011-07-12 |
Acute Kidney Injury (2) · Kidney Failure, Chronic (2) · Reperfusion Injury (2) · Brain Death (1) · Kidney Cortex Necrosis (1) · Kidney Diseases (1) · Liver Diseases (1) · Pancreatic Diseases (1) · Renal Insufficiency (1) · Renal Insufficiency, Chronic (1)
Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Male Urogenital Diseases (7) · Urogenital Diseases (7) · Urologic Diseases (7) · Kidney Diseases (6) · Renal Insufficiency (5) · Chronic Disease (3) · Disease Attributes (3) · Cardiovascular Diseases (2) · Postoperative Complications (2) · Renal Insufficiency, Chronic (2) · Vascular Diseases (2)
Acetylcysteine (2) · Saline Solution (2) · Sodium Chloride (2) · Everolimus (1) · Infusions, Intravenous (1) · Mycophenolic Acid (1) · Niacinamide (1) · Oxygen (1) · Plasma-lyte 148 (1) · Plasmalyte A (1) · Tacrolimus (1) · eculizumab (1) · heme arginate (1) · pegcetacoplan (1) · ravulizumab (1)
Alexion Pharmaceuticals, Inc. (2) · Angion Biomedica Corp (1) · Apellis Pharmaceuticals, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Institut d'Anesthesiologie des Alpes Maritimes (1) · Matthew Cooper (1) · Quark Pharmaceuticals (1) · Radboud University Medical Center (1) · Shahid Beheshti University of Medical Sciences (1) · The University of Queensland (1) · University of Edinburgh (1) · University of Medicine and Dentistry of New Jersey (1)
United States (6) · France (5) · Australia (4) · Brazil (4) · Canada (3) · Czechia (3) · Germany (3) · Spain (3) · Argentina (2) · Belgium (2) · Italy (2) · Netherlands (2) · United Kingdom (2) · Austria (1) · China (1)
Baburao Koneru, M.D. (1) · Carole R Ichai, MD, PhD (1) · Jamshid Salamzadeh, PhD (1) · John Holman, M.D.,Ph.D. (1) · John Neylan, MD (1) · Lorna Marson (1) · Matthew Cooper (1) · Michael Collins, MBChB,FRACP,PhD (1) · Steven Chadban, BMed(hons),FRACP,PhD (1) · Tom Darius, MD, PhD (1)
PMID 25250647, PMID 32450917, PMID 35042554, PMID 37343576, PMID 37916745, PMID 41323959, PMID 42763038