10 completed, 2 terminated. 6 Phase 2, 5 Phase 1, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 6 |
| Phase 1 | 5 | Completed 5 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
| Phase 4 | 1 | Terminated 1 |
Follow heme arginate: new trials by email Literature Review of heme arginate trials Research Report on heme arginate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heme Arginate in Transplantation Study Heme Arginate 25 MG/ML, 0.9% Sodium-chloride - Renal Transplant Rejection, Renal Transplant Failure | Phase 3 | Terminated | University of Edinburgh | 47 | 2019-03-12 | 2025-11-17 |
| The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart Heme arginate 3mg/kg, Heme arginate 1mg/kg, Placebo - Myocardial Ischemia | Phase 2 | Completed | Martin Andreas, M.D. | 31 | 2015-03-29 | 2021-02-15 |
| Heme Arginate in Cardiac Surgery Patients Heme arginate - Acute Kidney Injury | Phase 2 | Completed | University of Edinburgh | 20 | 2014-10-17 | 2024-09-19 |
| Hemin to Prevent Post-ERCP (Endoscopic Retrograde Cholangiopancreatography) Acute Pancreatitis Hemin, placebo - Post-ERCP Acute Pancreatitis | Phase 2 | Completed | Erasme University Hospital | 284 | 2012-04-01 | 2021-07-07 |
| Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Donor Renal Transplantation Heme arginate (Normosang), 0.9% sodium chloride - Graft Failure, Ischemia-reperfusion Injury | Phase 3 | Completed | University of Edinburgh | 40 | 2012-01-01 | 2015-05-27 |
| Heme Oxygenase (HO) Activity and Adenosine Induced Vasodilation L-arginine + heme arginate, Heme arginate + L-arginine - Atherosclerotic Cardiovascular Disease | Phase 4 | Terminated | Radboud University Medical Center | 6 | 2009-03-01 | 2011-08-11 |
| Effects of Heme Arginate in Healthy Male Subjects saline solution, heme arginate - Healthy Subjects, Heme Oxygenase | Phase 1 | Completed | Daniel Doberer | 15 | 2007-10-01 | 2013-01-15 |
| Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction? Heme arginate - Acute Myocardial Infarction | Phase 1 / Phase 2 | Completed | University Medical Center Groningen | 15 | 2007-07-01 | 2010-09-20 |
| Phase I Study of Heme Arginate With or Without Tin Mesoporphyrin in Patients With Acute Attacks of Porphyria heme arginate, tin mesoporphyrin - Porphyria | Phase 1 | Completed | National Center for Research Resources (NCRR) | 24 | 1998-01-01 | 2005-06-24 |
| Phase I Study of Tin Mesoporphyrin in Patients on Long Term Heme Therapy for Prevention of Acute Attacks of Porphyria heme arginate, tin mesoporphyrin - Porphyria | Phase 1 | Completed | National Center for Research Resources (NCRR) | 20 | 1998-01-01 | 2005-06-24 |
| Studies in Porphyria III: Heme and Tin Mesoporphyrin in Acute Porphyrias heme arginate, tin mesoporphyrin - Porphyria | Phase 2 | Completed | National Center for Research Resources (NCRR) | 32 | 1997-09-01 | 2005-06-24 |
| Phase I/II Study of Heme Arginate and Tin Mesoporphyrin for Acute Porphyria heme arginate, tin mesoporphyrin - Porphyria | Phase 1 / Phase 2 | Completed | National Center for Research Resources (NCRR) | 59 | 1993-07-01 | 2005-06-24 |
Metabolism, Inborn Errors (4) · Porphyrias (4) · Rare Diseases (4) · Reperfusion Injury (3) · Acute Coronary Syndrome (1) · Acute Kidney Injury (1) · Atherosclerosis (1) · Delayed Graft Function (1) · Myocardial Ischemia (1) · Non-ST Elevated Myocardial Infarction (1) · Porphyria, Acute Intermittent (1)
National Center for Research Resources (NCRR) (4) · University of Edinburgh (3) · Daniel Doberer (1) · Erasme University Hospital (1) · Martin Andreas, M.D. (1) · Radboud University Medical Center (1) · University Medical Center Groningen (1)
United Kingdom (3) · Austria (2) · Netherlands (2) · Belgium (1) · Taiwan (1) · United States (1)
Karl Elmo Anderson (4) · Alfred Kocher, M.D. (1) · Arnaud Lemmers, MD,PhD (1) · David C Kluth, MD (1) · David Kluth, PhD (1) · Jeremy Hughes, MD (1) · Lorna Marson (1) · Lorna Marson, MD (1) · Prof. F. Zijlstra, MD, PhD (1) · Rachel Thomas, MBChB (1) · Stephen McNally, PhD (1) · Vipin Zamvar, MD (1)
PMID 26680374, PMID 30354231, PMID 38431445
2014 (1)