39 completed, 11 unknown, 5 recruiting, 2 not yet recruiting. 54 Not applicable, 2 Phase 3, 1 Phase 1, 1 Phase 2.
Follow Cryotherapy Effect: new trials by email Literature Review of Cryotherapy Effect trials Research Report on Cryotherapy Effect
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs - ACL, Opioid Use | Not applicable | Not yet recruiting | Columbia University | 130 | 2027-11-01 | 2026-10-28 |
| This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. Endo-ice (Refrigerant Spray), Ice-sticks - Root Canal Treatment, Intra-operative Pain | Not applicable | Not yet recruiting | Dow University of Health Sciences | 90 | 2026-09-15 | 2026-08-25 |
| Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in Patients With Stable Angina or ACS - A Traditional Feasibility Study Intracoronary Cryotherapy - Coronary Arterial Disease (CAD), Plaque | Not applicable | Recruiting | Cryotherapeutics SA | 30 | 2026-03-01 | 2026-10-30 |
| Cryoanalgesia and Post-thoracotomy Pain in Minimally Invasive Cardiothoracic Surgery Atricure Inc. Nitrous oxide Cryoprobe - Cryotherapy Effect, Post Operative Pain | Not applicable | Withdrawn | University of Alberta | 2025-09-01 | 2026-05-08 | |
| Percutaneous Intercostal Cryoneuromodulation Onset Timing. Physical examination of chest skin - Cryotherapy Effect, Pectus Excavatum | Recruiting | Papa Giovanni XXIII Hospital | 20 | 2025-06-07 | 2025-07-23 | |
| Cryotherapy on Muscle Function Cold pack application, Cold spray application - Cold, Cryotherapy | Not applicable | Completed | Okan University | 52 | 2025-05-15 | 2025-06-06 |
| Acute Effects of Cryotherapy on Muscle Properties an ice massage, the cold spray - Cryotherapy Effect | Not applicable | Unknown | Istanbul University - Cerrahpasa | 52 | 2024-12-15 | 2024-09-23 |
| Utility of Intermittent Cryo-Compression Versus Traditional Icing Following Arthroscopic Rotator Cuff Repair Cryo-compression, Cryo-therapy - Rotator Cuff Injuries, Cryotherapy Effect | Not applicable | Recruiting | Allina Health System | 100 | 2024-08-05 | 2026-01-27 |
| A Cryotherapy With Tranexamic Acid Versus Normal Saline in the Treatment of Melasma TargetCool - Cryotherapy Effect | Not applicable | Unknown | Mahidol University | 18 | 2024-07-01 | 2024-07-09 |
| National Registry of Surgical Treatment and Percutaneous Cryoablation of Parietal Endometriosis Endometriosis, Cryotherapy Effect | Recruiting | Centre Hospitalier Intercommunal Creteil | 300 | 2024-06-15 | 2025-11-28 | |
| Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block - Thoracic Surgery, Video-Assisted | Not applicable | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 80 | 2023-11-09 | 2025-07-04 |
| Intercostal Cryoanalgesia for Chronic Pain After VATS Lung Resection Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block - Cryotherapy Effect, Chronic Pain | Not applicable | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 80 | 2023-11-09 | 2025-07-04 |
| Effect of Cryolipolysis on Insulin Resistance Cryolipolysis - Type 2 Diabetes Mellitus in Obese, Cryotherapy Effect | Not applicable | Unknown | Cairo University | 60 | 2023-11-01 | 2024-01-25 |
| Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchathani 3M cold pack, Perskindol cold spray, Placebo - Ankle Fractures, Swelling | Not applicable | Unknown | Thai Traditional Medical Knowledge Fund | 90 | 2023-08-01 | 2024-03-05 |
| Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament Reconstruction Surgery Continuous compression cryotherapy, Conventional ice treatment - Postoperative Pain, Acute, Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | University Medical Center Ho Chi Minh City (UMC) | 72 | 2023-06-01 | 2024-10-08 |
| The Effect of Brief Skin Cooling on Isometric Muscle Strength Cheer, The cold pressure test - Cryotherapy Effect | Not applicable | Completed | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 15 | 2023-04-10 | 2023-10-12 |
| Cooling Induces Motor Facilitation With Sympathetic Activation Brief skin cooling - Cryotherapy Effect | Not applicable | Completed | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 11 | 2023-04-03 | 2023-04-27 |
| Cryotherapy Post-haemorrhoidectomy (CYPHER) Randomized Controlled Trial Transanal ice pack - Hemorrhoids, Postoperative Pain | Not applicable | Unknown | Singapore General Hospital | 50 | 2023-04-01 | 2023-08-22 |
| Evaluation of Cryotherapy in Granuloma Pyogenicum Cryopen - Cryotherapy - Granuloma, Pyogenic, Cryotherapy Effect | Not applicable | Unknown | Medical University of Graz | 200 | 2023-01-01 | 2024-03-15 |
| Cryotherapy Efficacy During Pulp Therapy of the Mandibular First Permanent Molars in Children Cryotherapy - Cryotherapy Effect, Irreversible Pulpitis | Not applicable | Unknown | Minia University | 140 | 2022-06-01 | 2022-07-01 |
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Pain, Postoperative (10) · Agnosia (2) · Motor Activity (2) · Pain (2) · Adenocarcinoma of Lung (1) · Angina, Unstable (1) · Ankle Fractures (1) · Anterior Cruciate Ligament Injuries (1) · Arthritis, Rheumatoid (1) · Bronchial Neoplasms (1) · Bronchitis, Chronic (1) · Cardiomyopathies (1) · Chronic Pain (1) · Cicatrix (1) · Common Cold (1)
Pathological Conditions, Signs and Symptoms (21) · Signs and Symptoms (17) · Pathologic Processes (15) · Neurologic Manifestations (14) · Pain (12) · Postoperative Complications (9) · Respiratory Tract Diseases (5) · Stomatognathic Diseases (5) · Infections (4) · Neoplasms (4) · Mouth Diseases (3) · Musculoskeletal Diseases (3) · Neoplasms by Site (3) · Nervous System Diseases (3) · Respiratory Tract Infections (3)
Cryotherapy (12) · pembrolizumab (2) · Carboplatin (1) · Cryosurgery (1) · Electric Stimulation (1) · Exercise (1) · Exercise Therapy (1) · Ice (1) · Immersion (1) · Isotonic Solutions (1) · Lasers (1) · Pemetrexed (1) · spartalizumab (1)
Centre hospitalier de l'Université de Montréal (CHUM) (3) · Centre Hospitalier Universitaire de Besancon (2) · Cryotherapeutics SA (2) · Istanbul Physical Medicine Rehabilitation Training and Research Hospital (2) · Mahidol University (2) · Paulista University (2) · University of North Carolina, Greensboro (2) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (1) · Allina Health System (1) · Asir John Samuel (1) · Ataturk University (1) · Burcu Camcıoğlu Yılmaz (1) · CSA Medical, Inc. (1) · Cairo University (1) · Centre Hospitalier Intercommunal Creteil (1)
United States (11) · France (6) · Turkey (Türkiye) (6) · Brazil (4) · Canada (4) · Egypt (4) · Thailand (3) · South Korea (2) · United Kingdom (2) · Austria (1) · Belgium (1) · China (1) · Croatia (1) · Cyprus (1) · Georgia (1)
Alex Moore, MD (2) · Abeline R Watkins, BSc (1) · Akram Abd El Aziz, Assist.Prof (1) · Andrew O'Connell, MD (1) · Ashley B Bozzay, MD (1) · Asir J Samuel, MPT (1) · Carlos Collet, MD (1) · Charussri Leeyaphan, Assoc. Prof. (1) · Danielle R Payne, MSN (1) · Erik Ahlstrand, physician (1) · Farah Naz, BDS, FCPS (1) · Franz Rommel, physician (1)
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