8 completed, 7 unknown, 1 enrolling by invitation, 1 recruiting. 5 Not applicable, 5 Phase 4, 4 Phase 2, 3 Phase 3, 1 Phase 1.
Follow Isotonic Solutions: new trials by email Literature Review of Isotonic Solutions trials Research Report on Isotonic Solutions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance Tissue Plasminogen Activator (tPA), Isotonic solution - Tissue Plasminogen Activator, Intraventricular Brain Hemorrhage | Phase 4 | Enrolling by invitation | David Dornbos | 80 | 2026-07-31 | 2026-08-06 |
| Apimostinel + Automated Neurocognitive Training for Depression Apimostinel Infusion, Intravenous, Cognitive Training, Sham Training - Depression | Phase 2 | Recruiting | Rebecca Price | 150 | 2024-10-28 | 2026-08-10 |
| The Effect on Envelope of Motion in Asymptomatic Bruxers Botulinum toxin type A, Placebo - Tooth Wear, Bruxism | Not applicable | Unknown | Region Västerbotten | 60 | 2023-09-01 | 2023-05-03 |
| Comparison of Hemodynamic Results of Two Different Fluid Managements isotonic solution, Noradrenaline - Perioperative Fluid Management | Not applicable | Unknown | Istanbul University | 40 | 2022-04-01 | 2023-10-23 |
| Comparison of Different Local Anesthetic Dose in Suprascapular and Axillary Blocks in Shoulder Arthroscopies Bupivacaine hydrogen chloride (HCl) 0.025 % in 15+15 ML Injection, Bupivacaine HCl 0.025 % in 10+10 ML Injection, Bupivacaine HCl 0.025 % in 5+5 ML Injection - Pain, Postoperative | Not applicable | Completed | Istanbul University | 132 | 2021-07-15 | 2022-03-02 |
| Efficacy Of Magnesium In Radicular Pain When Added To Local Anesthetics And Steroids In Transforaminal Epidural Injection magnesium, Methylprednisolone, Bupivacaine Hydrochloride - Neuropathy, Pain | Phase 1 | Unknown | Fayoum University | 100 | 2020-08-30 | 2020-08-31 |
| Dexmedetomidine Compared to Ondansetron for Postanaesthetic Shivering in Patients Undergoing a Cesarean Section saline solution - Postanesthetic Excitement, Cesarean Section | Phase 2 | Completed | Hospital Central "Dr. Ignacio Morones Prieto" | 40 | 2020-08-05 | 2024-03-01 |
| Efficacy of Mouth-rinse With Chlorhexidine for the Prevention of Ventilator-associated Infections in Intensive Care Unit Mouth-rinse with 0.12% clorhexidine, Mouth-rinse with isotonic solution with 1.5% sodium bicarbonate - Infections Associated With Mechanical Ventilation, Pneumonia Associated With Mechanical Ventilation | Not applicable | Unknown | Universidad Autónoma de Yucatán | 80 | 2019-11-11 | 2019-11-18 |
| Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes desferal, Isotonic saline - Diabetes Mellitus, Type 1 | Phase 2 | Unknown | Karolinska University Hospital | 30 | 2017-01-01 | 2022-05-26 |
| Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block Magnesium Sulfate, Lidocaine, Isotonic Solution - Neuromuscular Block | Phase 4 | Completed | University of Sao Paulo | 48 | 2015-07-01 | 2016-01-15 |
| The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy Sevoflurane, Remifentanil, Saline - Haemodynamic Rebound | Phase 4 | Unknown | Inonu University | 58 | 2014-10-01 | 2014-10-22 |
| Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy Sevoflurane, Ketamine, Saline - Depressive Disorder | Phase 4 | Unknown | Inonu University | 60 | 2014-07-01 | 2014-10-20 |
| Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia 0.3% Saline in 3.3% dextrose, 0.45% Saline in 5% dextrose, 0.9% Saline in 5% dextrose - Hyponatremia | Phase 3 | Completed | Instituto Tecnologico y de Estudios Superiores de Monterey | 161 | 2013-07-01 | 2016-12-16 |
| Nasal Irrigation in Infants With Bronchiolitis. Isotonic solution (NaCl 0.9%), Hypertonic solution (NaCl 3%) - Bronchiolitis | Phase 3 | Completed | IRCCS Burlo Garofolo | 133 | 2012-10-01 | 2014-06-13 |
| Efficacy of Prontosan Solution on Chronic Ulcers Prontosan wound irrigation solution, Isotonic solution (saline or lactated ringer) - Pressure Ulcer, Chronic Wound Care | Phase 3 | Completed | Associazione Infermieristica per lo studio delle Lesioni Cutanee | 289 | 2011-04-01 | 2014-01-15 |
| MSC and HSC Coinfusion in Mismatched Minitransplants Mesenchymal stem cells, Isotonic solution - Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute | Phase 2 | Terminated | University of Liege | 39 | 2010-07-01 | 2021-09-08 |
| Effects of Cold Application and Heparinoid on Periorbital Edema and Ecchymosis Routine care, Cold gel pack, Heparinoids Topical Cream - Neurological Disorder, Nursing Caries | Not applicable | Completed | Necmettin Erbakan University | 90 | 2009-10-01 | 2019-10-08 |
| Study of Maternal Hydration on the Increase of Amniotic Fluid Index isotonic solution, water - Pregnancy | Phase 4 | Completed | UPECLIN HC FM Botucatu Unesp | 99 | 1998-07-01 | 2008-03-14 |
Bronchiolitis (1) · Bruxism (1) · Cross Infection (1) · Depression (1) · Depressive Disorder (1) · Diabetes Mellitus, Type 1 (1) · Ecchymosis (1) · Emergence Delirium (1) · Hodgkin Disease (1) · Hyponatremia (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, Non-Hodgkin (1) · Multiple Myeloma (1)
Inonu University (2) · Istanbul University (2) · Associazione Infermieristica per lo studio delle Lesioni Cutanee (1) · David Dornbos (1) · Fayoum University (1) · Hospital Central "Dr. Ignacio Morones Prieto" (1) · IRCCS Burlo Garofolo (1) · Instituto Tecnologico y de Estudios Superiores de Monterey (1) · Karolinska University Hospital (1) · Necmettin Erbakan University (1) · Rebecca Price (1) · Region Västerbotten (1) · UPECLIN HC FM Botucatu Unesp (1) · Universidad Autónoma de Yucatán (1) · University of Liege (1)
Turkey (Türkiye) (4) · Italy (2) · Mexico (2) · Sweden (2) · United States (2) · Belgium (1) · Brazil (1)
Feray Erdil, MD (2) · Augustin Ferrant, MD, PhD (1) · Carlos Graux, MD, PhD (1) · Chantal Doyen, MD, PhD (1) · Chantal Lechanteur, PhD (1) · Claudia Montserrat Flores Robles, MD (1) · Dino Barbi, MD (1) · Dominik Selleslag, MD, PhD (1) · Dominique Bron, MD, PhD (1) · Etienne Baudoux, MD (1) · Evelyne Willems, MD (1)
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