28 completed, 11 unknown, 5 terminated, 2 active not recruiting. 33 Not applicable, 7 Phase 2, 4 Phase 4, 3 Phase 1, 2 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Foot Massage With a Massage Roller on Chemotherapy-Related Neuropathic Pain Roller Massage, Ice therapy - Neuropathic Pain, Chemotherapy Induced Pain Neuropathy | Not applicable | Completed | Ataturk University | 80 | 2026-02-01 | 2026-09-01 |
| The Effect of Cold Application on Nausea and Vomiting After Bariatric Surgery ICE - Obese Patients With Bariatric Surgery | Not applicable | Completed | Sakarya University | 60 | 2025-05-01 | 2026-09-17 |
| COMPARISON OF THE TOPICAL ANAESTHETIC EFFICACY OF VARIOUS AGENTS WITH ANAESTHETIC EFFECTS IN CHILDREN Vemcaine, Essences and Essential Oils, VISION - Anxiety | Not applicable | Completed | Uşak University | 50 | 2025-04-01 | 2026-09-30 |
| Comparison Study of EAP and Disease-Specific Chemotherapy Regimens in Hematopoietic Stem Cell Mobilization for Lymphoma Etoposide, Cytarabine, PEG-rhG-CSF - Non-Hodgkin's Lymphoma, Hematopoietic Stem Cell Mobilization | Phase 3 | Recruiting | The Affiliated People's Hospital of Ningbo University | 99 | 2024-08-01 | 2025-12-04 |
| Oral Cryotherapy Applied to Patients Undergoing Chemotherapy ICE - Oncologic Disease, Cancer | Not applicable | Completed | Karadeniz Technical University | 65 | 2024-07-01 | 2025-06-19 |
| Pembrolizumab in Combination With Salvage Chemotherapy for First-relapsed or Refractory Classical Hodgkin Lymphoma Pembrolizumab plus Chemotherapy (ICE or DHAP) - Classical Hodgkin Lymphoma | Phase 2 | Recruiting | University of Cologne | 29 | 2024-03-05 | 2024-08-23 |
| Research on Post-Stroke Anticoagulation Strategies for Atrial Fibrillation Based on Left Atrial Appendage Flow Velocity Measured by Intracardiac Echocardiography (ICE) Intracardiac Echocardiography (ICE) for Differential Diagnosis - Atrial Fibrillation (AF) | Completed | Changhai Hospital | 172 | 2024-01-01 | 2026-02-27 | |
| Effects of Different Stimuli on Muscle Activation, Hand Grip Strength, Reaction Time, and Hand Function Ice, Vibration - Upper Extremity Dysfunction | Not applicable | Completed | Lokman Hekim University | 80 | 2023-03-30 | 2026-02-12 |
| Mosunetuzumab in Combination With Platinum-Based Salvage Chemotherapy in Patients With Relapsed/Refractory Aggressive B Cell Lymphoma Mosunetuzumab, DHAX, ICE - Large B-cell Lymphoma, High-grade B-cell Lymphoma | Phase 1 | Active not recruiting | Washington University School of Medicine | 24 | 2023-01-03 | 2026-01-08 |
| RESPONDER-HF Trial Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE) - Heart Failure, Heart Failure, Diastolic | Not applicable | Active not recruiting | Corvia Medical | 750 | 2022-11-17 | 2026-03-18 |
| Comparison of Peri-procedural Complications of Intracardiac Echocardiography and Transesophageal Echocardiography in Patients With Atrial Fibrillation ICE, TEE - Atrial Fibrillation | Not applicable | Unknown | Shanghai Chest Hospital | 1200 | 2022-08-01 | 2022-07-20 |
| Pain and Anxiety in Peripheral Venous Catheterization, Jet Lidocaine, Ice Application Jet lidocaine, Ice, Standard PVC procedure - Peripheral Venous Catheterization | Not applicable | Completed | Ataturk University | 80 | 2022-06-01 | 2025-04-30 |
| Topical Ice-therapy for Intravitreal Injections Ice-therapy, No Ice-therapy - Anesthesia; Hypothermia, Injection Site Irritation | Not applicable | Completed | University of Minnesota | 42 | 2022-04-01 | 2025-08-22 |
| ICE Based Atrial Flutter Ablation Vs Conventional Fluoroscopy/Anatomical Mapping Based Ablation - ICE Flutter Study 3D electroanatomical mapping alone guided CTI ablation, ICE plus 3D electroanatomical mapping guided CTI ablation - Atrial Flutter | Not applicable | Unknown | Kansas City Heart Rhythm Research Foundation | 60 | 2022-02-01 | 2022-02-08 |
| Impact of Cold Exposure on Metabolic Regulation in Children With Non Alcoholic Fatty Liver Disease (NAFLD) ICE - Non-Alcoholic Fatty Liver Disease | Not applicable | Unknown | Guy's and St Thomas' NHS Foundation Trust | 36 | 2021-10-23 | 2024-02-01 |
| Pain Control for Breast Cancer Patients Receiving Injection of Radioactive Tracer Lidocaine patch, Buzzy(R), Ice pack - Breast Cancer, Sentinel Lymph Node | Phase 3 | Completed | University of Wisconsin, Madison | 167 | 2021-04-23 | 2023-08-03 |
| Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery Opioid-sparing multimodal pain management, Usual care - Postoperative Pain, Narcotic Use | Not applicable | Completed | Ohio State University | 54 | 2021-04-19 | 2023-05-12 |
| Pre Injection Use of Cryoanesthesia Versus Topical Anesthetic Gel in Reducing Pain Perception During Palatal Injections Topical Benzocaine, Topical ice - Pain | Phase 4 | Completed | B.P. Koirala Institute of Health Sciences | 60 | 2021-03-19 | 2023-12-11 |
| ESWT in Lateral Epicondylitis: Clinical,Ultrasonographic Evaluation Extracorporeal Shock Wave Therapy (ESWT), Sham ESWT, Resting Splint , Exercises and ice - Lateral Epicondylitis, Tennis Elbow | Not applicable | Completed | Istanbul Medeniyet University | 42 | 2020-12-01 | 2024-04-02 |
| A Study of Evaluating the Safety and Efficacy of ATG-010 Combined With Chemotherapy Sequential With ATG-010 Monotherapy Maintenance in Peripheral T- and NK/T-cell Lymphoma ICE [ifosfamide+carboplatin+etoposide], GEMOX [gemcitabine+oxaliplatin], Tislelizumab - Peripheral T-cell Lymphoma, NK/T-cell Lymphoma | Phase 1 / Phase 2 | Terminated | Antengene Corporation | 56 | 2020-08-18 | 2026-01-05 |
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Atrial Fibrillation (3) · Hypothermia (3) · Lymphoma, Non-Hodgkin (3) · Neoplasms (3) · Osteoarthritis, Knee (3) · Pain (3) · Pain, Postoperative (3) · Anxiety Disorders (2) · Breast Neoplasms (2) · Heart Failure (2) · Low Back Pain (2) · Lymphoma, Large B-Cell, Diffuse (2) · Lymphoma, T-Cell, Peripheral (2) · Alzheimer Disease (1) · Ankle Injuries (1)
Ataturk University (2) · Corvia Medical (2) · NYU Langone Health (2) · Universidade Federal de Sao Carlos (2) · Antengene Corporation (1) · B.P. Koirala Institute of Health Sciences (1) · Barbara Ann Karmanos Cancer Institute (1) · Brigham and Women's Hospital (1) · Cairo University (1) · Cedars-Sinai Medical Center (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre Hospitalier de Verdun (1) · Changhai Hospital (1) · CoolSystems, Inc. (1) · Creighton University (1)
United States (21) · Turkey (Türkiye) (8) · Germany (6) · Canada (5) · Australia (3) · Brazil (3) · China (3) · France (3) · Netherlands (3) · Austria (2) · Belgium (2) · Poland (2) · Spain (2) · United Kingdom (2) · Croatia (1)
Sanjiv Shah, MD (2) · Andreas Engert, Prof. (1) · Ann K Ketz, PhD (1) · Caroline Ovadia, Doctor (1) · Cay Anderson-Hanley, PhD (1) · David Moreau, MSc (1) · David Russler-Germain, M.D., Ph.D. (1) · Dhanunjaya Lakkireddy, MD (1) · Gabriele Calaminus, MD (1) · Gilbert Grant (1) · Gilbert Grant, MD (1) · Heather B Neuman, MD (1)
PMID 20852299, PMID 23692856, PMID 24345205, PMID 25233569, PMID 27825572, PMID 30200183, PMID 30233154, PMID 30610026, PMID 31521551, PMID 32611866, PMID 33261633, PMID 33633029, PMID 33650998, PMID 34326589, PMID 34688915, PMID 35120593, PMID 36538309, PMID 36740018, PMID 36939661, PMID 37480877, PMID 37989800, PMID 38630494, PMID 38934964, PMID 39237070, PMID 39566948, PMID 40714684, PMID 41060665, PMID 41947115, PMID 41992252, PMID 42268170, PMID 42438166
2009 (1), P30CA022453 (1), R41AG053120 (1), T32CA090217 (1)