105 completed, 25 unknown, 19 recruiting, 15 not yet recruiting. 76 Not applicable, 4 Phase 2, 3 Phase 3, 3 Phase 4.
Follow Critical Care: new trials by email Literature Review of Critical Care trials Research Report on Critical Care
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Consensus on Low-resource Setting Definition: An inteRnational Delphi sTudY (CLARITY-LRS) Resource-Limited Setting, Delphi Study | Not yet recruiting | University Clinical Centre of Republic of Srpska | 50 | 2027-02-01 | 2026-09-17 | |
| Computed Inspiratory Muscle Pressure to Monitor Inspiratory Effort During Pressure-Targeted Assist/Control Ventilation Positive end-expiratory pressure 11, Positive end-expiratory pressure 9, Positive end-expiratory pressure 7 - Mechanical Ventilation, Critical Care | Not applicable | Not yet recruiting | Jian-Xin Zhou | 30 | 2026-11-01 | 2026-10-21 |
| Computed Inspiratory Muscle Pressure to Monitor Inspiratory Effort During Pressure Support Ventilation Pressure support 15, Pressure support 13, Pressure support 11 - Mechanical Ventilation, Critical Care | Not applicable | Not yet recruiting | Jian-Xin Zhou | 30 | 2026-11-01 | 2026-10-21 |
| Simulation-based Training in the Anaesthesia Residency Curriculum Education, Training | Not yet recruiting | Brno University Hospital | 150 | 2026-10-01 | 2026-08-18 | |
| Trachphone vs Warm Air Humidification for Acute Trache Patients on ICU Tracheostomy, Ventilated Patients | Not yet recruiting | Tameside General Hospital | 35 | 2026-10-01 | 2026-10-07 | |
| JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion Ultrasound assessment - Intracranial Pressure, Critical Care | Not yet recruiting | University Hospital, Bordeaux | 30 | 2026-09-01 | 2026-06-24 | |
| NEURO - Prognostication Using Late Somatosensory Evoked - Potentials EEGs - Comatose, Prognosis | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 50 | 2026-06-30 | 2026-04-02 |
| Mechanical Insufflation-Exsufflation in Critically Ill Patients Delphi Questionnaire - Airway Clearance, Mechanical Insufflation-exsufflation | Recruiting | Medipol University | 30 | 2026-06-10 | 2026-10-07 | |
| Electrophysiological Analysis of Gamma-Hydroxybutyrate-induced Sleep in Intensive Care Patients GHB, Placebo - Sleep Disorder (Disorder), Critical Care | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-06-01 | 2026-05-22 |
| Interprofessional Collaboration in the Cardiac Intensive Care Unit (CICU): An Action-Research Training Project The training phase of the project consists of an interactive course aimed at healthcare professionals (physicians, nurses and OSS) to improve their ability to recognise and enact effective collaborati - Interprofessional Relations, Interprofessional Education | Not applicable | Not yet recruiting | Azienda Ospedaliero-Universitaria di Parma | 60 | 2026-02-15 | 2026-01-22 |
| Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial PMI-targeted pressure support setting and adjustment, VT/RR-targeted pressure support setting and adjustment - Critical Care, Acute Hypoxic Respiratory Failure | Not applicable | Recruiting | Capital Medical University | 619 | 2026-01-19 | 2026-01-21 |
| Effects of Artificial Intelligence Nurse Orientation Program on Psychological Outcomes and Length of Hospital Stay in Intensive Care Unit Structured orientation program, Human Nurse - Delirium, Anxiety and Depression | Not applicable | Not yet recruiting | Koç University | 10 | 2025-11-01 | 2025-09-15 |
| Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit. Mechanical Ventilation, Pulmonary Rehabilitation | Recruiting | Universita degli Studi di Genova | 2400 | 2025-10-01 | 2026-09-15 | |
| Focused Ultrasound Spleen Stimulation and Inflammation in Septic Shock Focused Ultrasound Spleen Neuromodulation - Septic Shock, Inflammatory Cytokines | Not applicable | Recruiting | First Affiliated Hospital of Wannan Medical College | 40 | 2025-07-25 | 2026-05-19 |
| Early Multimodal Therapy and Mechanical Ventilation Early Multimodal Therapy, Late Multimodal Therapy - Critical Care, Critical Illness | Not applicable | Not yet recruiting | Fundación Santa Fe de Bogota | 74 | 2025-07-01 | 2025-07-09 |
| Bed Bath With Auditory Hypnosis on ICU Patients Bed Bath With Auditory Hypnosis - Critical Care | Not applicable | Completed | Banu Terzi | 66 | 2025-06-15 | 2026-10-15 |
| Use of Endotracheal Tube Cuff Pressure to Assess Inspiratory Effort During Pressure Support Ventilation Pressure support 15, Pressure support 13, Pressure support 11 - Mechanical Ventilation, Critical Care | Not applicable | Completed | Jian-Xin Zhou | 30 | 2025-05-20 | 2026-01-21 |
| Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments HFNC:50L/min, HFNC:flow=40L/min, HFNC:flow=30L/min - Critical Care, Inspiratory Effort | Not applicable | Recruiting | Jian-Xin Zhou | 26 | 2025-05-20 | 2025-05-22 |
| Effects of Nonpharmacological Interventions in Sleep Quality, Anxiety, and Delirium for Patients of Adult Intensive Care Units music combined with lavender essential oil group - Intensive Care Unit, Critical Care | Not applicable | Not yet recruiting | Chiayi Christian Hospital | 154 | 2025-03-14 | 2025-01-14 |
| Atrial Strain in Septic Shock Septic Shock, Left Atrial Strain | Recruiting | Centre Hospitalier Universitaire, Amiens | 60 | 2025-03-06 | 2026-01-16 |
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Critical Illness (13) · Respiratory Insufficiency (6) · Anxiety Disorders (5) · Delirium (5) · Depression (5) · Respiratory Aspiration (5) · Agnosia (4) · COVID-19 (4) · Sepsis (4) · Sleep Initiation and Maintenance Disorders (4) · postintensive care syndrome (4) · Cardiovascular Diseases (3) · Diabetes Mellitus (3) · Emergencies (3) · Muscular Diseases (3)
Pathological Conditions, Signs and Symptoms (53) · Pathologic Processes (35) · Nervous System Diseases (23) · Signs and Symptoms (23) · Disease Attributes (20) · Respiratory Tract Diseases (19) · Neurologic Manifestations (18) · Infections (14) · Mental Disorders (13) · Behavior (11) · Respiration Disorders (10) · Neurobehavioral Manifestations (9) · Lung Diseases (8) · Behavioral Symptoms (7) · Cardiovascular Diseases (7)
Music Therapy (2) · Administration, Inhalation (1) · Albumins (1) · Algorithms (1) · Blood Specimen Collection (1) · Bumetanide (1) · Catheterization (1) · Central Venous Catheters (1) · Cholecalciferol (1) · Clinical Protocols (1) · Daptomycin (1) · Data Collection (1) · Dexmedetomidine (1) · Dialysis Solutions (1) · Diuretics (1)
Jian-Xin Zhou (6) · University Hospital, Clermont-Ferrand (6) · McMaster University (5) · Technical University of Munich (5) · Centre Hospitalier Universitaire, Amiens (4) · French Society for Intensive Care (4) · Hospital de Clinicas de Porto Alegre (4) · Nantes University Hospital (4) · Oslo University Hospital (4) · Capital Medical University (3) · National Taiwan University Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Centre Hospitalier Universitaire de Besancon (2) · Charite University, Berlin, Germany (2) · Great Ormond Street Hospital for Children NHS Foundation Trust (2)
France (34) · China (14) · United States (13) · Germany (11) · Turkey (Türkiye) (11) · United Kingdom (11) · Brazil (10) · Canada (10) · Italy (6) · Netherlands (5) · Norway (5) · Spain (5) · Sweden (5) · Taiwan (4) · Belgium (3)
Jian-Xin Zhou, MD, PhD (4) · Jian-Xin Zhou, MD (3) · Hennig Wackerhage, PhD (2) · Jian-Xin Zhou (2) · Michelle Kho, PT, PhD (2) · Stefan J Schaller, MD (2) · Stefan J Schaller, MD, MHBA (2) · Abele Donati, MD (1) · Ada C Gastaldi, PhD (1) · Adriano J Pereira, MD PhD (1) · Adriano J Pereira, MD, PhD (1) · Alan Adulla, PhD (1)
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2017 (1), 2025 (1), 5UL1TR001420-03 (1), K23HL138206 (1), R01HL168474 (1), R01LM013606 (1), R01NR015768 (1), R01NR019831 (1), R03AG060076 (1)