13 completed. 13 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 13 |
| Phase 2 | 2 | Completed 2 |
Follow Craniofacial Abnormalities: new trials by email Literature Review of Craniofacial Abnormalities trials Research Report on Craniofacial Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Augmented Reality for Orthognatic Surgery Patient Education Patient consultation - Malocclusion, Dentofacial Deformities | Phase 2 / Phase 3 | Completed | University Medical Center Groningen | 60 | 2023-10-01 | 2025-03-30 |
| A Single Bolus of Dexmedetomidine Versus Normal Saline in Postoperative Agitation Dexmedetomidine, 0.9% saline - Cleft Palate | Phase 3 | Completed | Assiut University | 60 | 2021-06-20 | 2026-05-07 |
| Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome Simvastatin, Placebo - Noonan Syndrome | Phase 3 | Completed | University Hospital, Toulouse | 53 | 2017-01-25 | 2023-05-11 |
| Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery Tranexamic Acid, saline solution - Peri-operative Hemorrhage or Hematoma, Surgery | Phase 3 | Completed | University Hospital, Lille | 157 | 2016-01-03 | 2026-04-22 |
| Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Levobupivacaine, Bupivacaine - Recovery After Cleft Palate Surgery | Phase 2 / Phase 3 | Completed | Assiut University | 60 | 2016-01-01 | 2017-09-07 |
| Investigating the Long-term Efficacy and Safety of Two Doses of NN-220 (Somatropin) in Short Stature Due to Noonan Syndrome somatropin - Genetic Disorder, Noonan Syndrome | Phase 3 | Completed | Novo Nordisk A/S | 51 | 2013-08-19 | 2020-08-10 |
| Genetic Testing of Noonan Subjects Previously Treated With Norditropin®. An Extension to Trial GHNOO-1658 somatropin - Genetic Disorder, Noonan Syndrome | Phase 3 | Completed | Novo Nordisk A/S | 22 | 2008-09-01 | 2023-08-09 |
| Comparative Results of Maxillary Deficiency Treatment by Tongue Plate and Facemask in Growing Patients Tongue plate, Facemask - Maxillary Deficiency | Phase 3 | Completed | Shahid Beheshti University of Medical Sciences | 20 | 2007-09-01 | 2008-12-19 |
| Oral Cleft Prevention Program Folic acid: 4 mg versus 0.4 mg per day - Cleft Lip, Cleft Palate | Phase 3 | Completed | University of Iowa | 4000 | 2006-11-01 | 2017-03-31 |
| A Comparison of Bupivacaine and Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting Ketorolac, Bupivacaine, ketorolac + bupivacaine - Postoperative Pain | Phase 3 | Completed | The Hospital for Sick Children | 54 | 2006-05-01 | 2013-08-20 |
| Oral Cleft Prevention Trial in Brazil Folic acid (0.4mg vs. 4.0mg) - Cleft Lip, Cleft Palate | Phase 3 | Completed | NICHD Global Network for Women's and Children's Health | 2200 | 2004-01-01 | 2013-12-17 |
| Effect of MAXOMAT ® on the Growth of Small Children to NOONAN's Syndrome MAXOMAT ®, biosynthetic growth hormone - Noonan Syndrome | Phase 3 | Completed | Sanofi | 36 | 1997-10-01 | 2010-10-05 |
| Somatropin Effect on Linear Growth and Final Height in Subjects With Noonan Syndrome somatropin - Genetic Disorder, Noonan Syndrome | Phase 3 | Completed | Novo Nordisk A/S | 24 | 1990-06-01 | 2017-01-18 |
Cleft Palate (5) · Noonan Syndrome (5) · Genetic Diseases, Inborn (3) · Cleft Lip (2) · Retrognathia (2) · Congenital Abnormalities (1) · Dentofacial Deformities (1) · Hematoma (1) · Malocclusion (1) · Pain, Postoperative (1) · Patient Satisfaction (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (13) · Musculoskeletal Abnormalities (13) · Musculoskeletal Diseases (13) · Congenital Abnormalities (12) · Maxillofacial Abnormalities (8) · Stomatognathic Diseases (8) · Stomatognathic System Abnormalities (8) · Jaw Abnormalities (7) · Jaw Diseases (7) · Cardiovascular Abnormalities (5) · Cardiovascular Diseases (5) · Connective Tissue Diseases (5) · Heart Defects, Congenital (5) · Heart Diseases (5)
Human Growth Hormone (4) · Bupivacaine (2) · Folic Acid (2) · Saline Solution (2) · Dexmedetomidine (1) · Ketorolac (1) · Levobupivacaine (1) · Simvastatin (1) · Tranexamic Acid (1)
Novo Nordisk A/S (3) · Assiut University (2) · NICHD Global Network for Women's and Children's Health (1) · Sanofi (1) · Shahid Beheshti University of Medical Sciences (1) · The Hospital for Sick Children (1) · University Hospital, Lille (1) · University Hospital, Toulouse (1) · University Medical Center Groningen (1) · University of Iowa (1)
France (3) · Egypt (2) · Sweden (2) · Brazil (1) · Canada (1) · Germany (1) · Iran (1) · Japan (1) · Netherlands (1) · United States (1)
Elsa Jozefowicz, MD (1) · J Kraeima, dr. (1) · Jason Hayes, MD (1) · Jeff Murray, M.D. (1) · Jeffrey Murray, MD (1) · Lida Toomarian (1) · Mahkameh Mirkarimi (1) · Omar Soliman (1) · Rahman Showkatbakhsh (1) · Thomas Edouard, MD, PHD (1)
PMID 16203673, PMID 19854614, PMID 21091369, PMID 23181832, PMID 23669628, PMID 29109363, PMID 32269181, PMID 34465477, PMID 41285480, PMID 42069961, PMID 42621140
2005 (1), 2008 (1), 2015 (1), U01DE017958 (1)