21 completed, 12 unknown, 5 recruiting, 4 enrolling by invitation. 20 Not applicable, 5 Phase 2, 3 Phase 3, 3 Phase 4, 2 Phase 1.
Follow COPD Exacerbation Acute: new trials by email Literature Review of COPD Exacerbation Acute trials Research Report on COPD Exacerbation Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderate COPD R-3750 - COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbation | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 27 | 2026-09-01 | 2026-01-29 |
| Rademikibart IV for Acute Asthma and COPD Exacerbation Rademikibart - Asthma Acute, COPD Exacerbation Acute | Phase 2 | Recruiting | Connect Biopharm LLC | 40 | 2026-08-21 | 2026-10-22 |
| Study on Home Obstructive Respiratory Exacerbations RESP™ Biosensor - COPD Exacerbation, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection | Enrolling by invitation | Strados Labs, Inc. | 20 | 2025-12-05 | 2026-01-20 | |
| Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease Titrated Oxygen, Standard Oxygen - COPD Exacerbation, COPD Exacerbation Acute | Phase 4 | Recruiting | Central Denmark Region | 1888 | 2025-06-02 | 2026-10-02 |
| Assessing Optimal Inhaler Strategies During Acute Exacerbations of COPD (AECOPDs) Using Oscillometry Long-acting bronchodilator therapy (LABD), Short-acting bronchodilator therapy (SABD) - COPD, COPD Exacerbation Acute | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 37 | 2025-06-01 | 2026-04-09 | |
| Study on Acupuncture Treatment of Chronic Airway Diseases(Asthma and Chronic Obstructive Pulmonary Disease) Acupuncture, Sham Acupuncture - COPD Exacerbation Acute, Asthma Acute | Not applicable | Not yet recruiting | Henan University of Traditional Chinese Medicine | 576 | 2025-03-01 | 2025-03-11 |
| The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease Pharmacological treatment - COPD, COPD Exacerbation Acute | Enrolling by invitation | University of Milan | 10000 | 2024-09-30 | 2026-05-04 | |
| The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 2 Frontier X2 - COPD Exacerbation Acute | Enrolling by invitation | University of Strathclyde | 30 | 2024-07-03 | 2025-04-10 | |
| The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 1 Pneumowave DC - COPD Exacerbation Acute | Enrolling by invitation | University of Strathclyde | 30 | 2024-06-24 | 2025-04-10 | |
| The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation CONTROL, PEP DEVICE, HFCWO DEVICE - COPD Exacerbation Acute | Not applicable | Completed | Saglik Bilimleri Universitesi | 33 | 2024-05-01 | 2026-04-29 |
| Multiparametric Home Telemonitoring of Patients With Chronic Obstructive Pulmonary Disease Exacerbation Telemonitoring - COPD, COPD Exacerbation Acute | Not applicable | Unknown | University of Trieste | 60 | 2024-03-29 | 2024-05-02 |
| Is a Collective Person-centered Dialogue Intervention for Hospitalised COPD Patients Feasible? The collective person-centered dialogue intervention - COPD Exacerbation Acute, Nutrition Poor | Not applicable | Completed | Hvidovre University Hospital | 11 | 2024-01-15 | 2024-09-19 |
| Comparison of Bronchodilator Treatment Practices in Group E COPD Patients Comparison of bronchodilator effectiveness of nebulizer therapy devices - COPD Exacerbation Acute | Not applicable | Unknown | Ataturk University | 39 | 2024-01-01 | 2023-12-20 |
| Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Non-invasive ventilation - COPD Exacerbation, COPD Exacerbation Acute | Not applicable | Unknown | Central Denmark Region | 140 | 2023-12-08 | 2024-01-18 |
| PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD PSV mode during NIV, ASV intellisync - COPD Exacerbation Acute, COPD Exacerbation | Not applicable | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 55 | 2023-12-01 | 2025-07-23 |
| RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection Vapendavir, Placebo - COPD Exacerbation Acute, COPD With Acute Lower Respiratory Infection | Phase 2 | Completed | Altesa Biosciences, Inc. | 52 | 2023-11-20 | 2025-09-30 |
| Clopidogrel for the Prevention of Exacerbations in Severe COPD Clopidogrel Bisulfate 75Mg Tab - COPD, COPD Exacerbation Acute | Phase 3 | Unknown | Lady Reading Hospital, Pakistan | 162 | 2023-10-01 | 2023-10-03 |
| Checklists Resuscitation Emergency Department Emergency Manual - Shortness of Breath, Chest Pain | Not applicable | Unknown | Region Skane | 2000 | 2023-09-01 | 2022-12-14 |
| Comparing the Effects of Manual Hyperinflation and Diaphragmatic Proprioceptive Neuromuscular Facilitation on Pulmonary Functions in Patients on Mechanical Ventilation manual hyperinflation, Diaphragmatic proprioceptive neuromuscular facilitation technique, traditional physiotherapy - COPD Exacerbation Acute | Not applicable | Unknown | omar hasham mohamed | 60 | 2023-08-30 | 2024-01-24 |
| Prevalence of Humoral Dysfunction in Pts With Frequent Exacerbations of COPD, and the Effect of SCIgR for Prevention CUVITRU - Ig subcutaneous human 20%, Standard Medical Therapy - COPD Exacerbation Acute | Phase 2 | Unknown | Rochester General Hospital | 40 | 2023-06-01 | 2023-06-15 |
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Ejvind Frausing Hansen, MD (1) · Eric Dryver, MD (1) · Gary T Ferguson, M.D. (1) · Gerard J Criner, MD (1) · Ingrid Poulsen, Prof. (1) · Jesper H Haunstrup Brendel, MD (1) · Karim Meeran, MBBS BSc MD (1) · Marco Confalonieri, MD (1) · Martin F Gude, PhD (1)
PMID 33558356, PMID 33726828, PMID 33985501, PMID 34320980, PMID 34893522, PMID 35012620, PMID 35473589, PMID 37848292, PMID 38273393, PMID 39555388, PMID 40384948, PMID 41320645, PMID 41442677, PMID 41529255, PMID 41628672, PMID 41773688, PMID 42219224, PMID 42432679, PMID 42517050
K23HL146946 (1), R01HL146644 (1)