10 completed, 4 unknown, 2 recruiting, 1 not yet recruiting. 5 Phase 3, 5 Phase 4, 3 Phase 2, 2 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 5 |
| Phase 4 | 5 | Completed 2, Unknown 2, Recruiting 1 |
| Phase 2 | 3 | Unknown 2, Completed 1 |
| Not applicable | 2 | Completed 1, Not yet recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Fluoroquinolones: new trials by email Literature Review of Fluoroquinolones trials Research Report on Fluoroquinolones
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Enhanced Treatment Strategy for Disseminated MAC Infection in HIV Patients: A Randomized Controlled Trial Standard Triple Therapy, Experimental: Standard Triple Therapy Plus Fluoroquinolone - Opportunistic Infections, HIV Related, Disseminated Mycobacterium Avium Complex Infection | Not applicable | Not yet recruiting | Shanghai Public Health Clinical Center | 124 | 2026-04-30 | 2026-05-13 |
| A Prospective Trial of Dalbavancin-Based Prophylaxis in Children and Adolescents With High-Risk Leukemia Dalbavancin, Fluoroquinolone (either ciprofloxacin or levofloxacin at the discretion of the treating clinician) - Leukemia, Acute Myeloid Leukemia | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 29 | 2025-05-22 | 2026-09-15 |
| Early Oral Switch for Uncomplicated Gram-negative Bacteraemia Oral fluoroquinolones (most commonly, ciprofloxacin) or oral trimethoprim-sulfamethoxazole, Standard of care intravenous antibiotics (e.g. ceftriaxone, cefazolin) - Gram-negative Bacteraemia | Phase 4 | Completed | Tan Tock Seng Hospital | 720 | 2022-06-03 | 2026-08-10 |
| NextGen - Clinical Implication of Next Generation Sequencing Antibiotic, Next Gen - Urinary Tract Infections | Phase 4 | Recruiting | Wake Forest University Health Sciences | 100 | 2022-05-17 | 2025-12-08 |
| Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD Beta-Lactams, Fluoroquinolone - COPD Exacerbation Acute | Phase 2 / Phase 3 | Completed | Haiphong University of Medicine and Pharmacy | 170 | 2020-01-01 | 2021-05-10 |
| Standard Antibiotic Versus Enhanced Prophylactic Measures on Rate of Urinary Tract Infection After Flexible Ureteroscopy IV fluoroquinolone 1 hour preoperatively and oral antibiotics for 24h postoperatively., Urine culture, antibiotic prophylaxis and hydrophilic-coated ureteral access sheaths - Urinary Tract Infections | Not applicable | Completed | Egyptian Biomedical Research Network | 100 | 2018-08-01 | 2021-01-29 |
| Fluoroquinolone Associated Disability Fluoroquinolone (FQ), Azithromycin (AZ), Sulfamethoxazole/Trimethoprim (ST) Fixed Dose Combination - Bronchitis, Sinusitis | Completed | Janssen Research & Development, LLC | 239306 | 2018-05-17 | 2019-01-29 | |
| A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events Oral Fluoroquinolones (FQ), Other Antibiotics, Febrile Illness Not Treated with Antibiotics Will be Analyzed as an Exposure - Retinal Detachment, Achilles Tendon | Completed | Janssen Research & Development, LLC | 117911 | 2017-11-20 | 2025-06-25 | |
| Adjunctive Therapy of Andrographolid Sulfonatein Community Acquired Pneumonia Andrographolid Sulfonate Injection (AS Injection), Cephalosporin, Azithromycin, Minocycline or Doxycycline - Community Acquired Pneumonia | Phase 4 | Unknown | Qingfeng Pharmaceutical Group | 462 | 2016-07-01 | 2018-04-10 |
| Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis PACK-CXL, Cefazolin in combination with either tobramycin or gentamicin, Cycloplegic agents (cyclopentolate 1% eye drops) - Keratitis; Infectious Disease (Manifestation) | Phase 3 | Completed | University Hospital, Geneva | 35 | 2016-03-01 | 2020-10-20 |
| Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Levofloxacin, Rifampicin, Conventional IV treatment of staphylococci IE following European guidelines 2015 including cloxacilline, oxacilline,gentamicine,vancomycine,rifampicine - Infective Endocarditis | Phase 3 | Completed | University Hospital, Tours | 162 | 2016-02-29 | 2026-02-12 |
| Antibiotic Treatment Trial for Small Intestinal Bacterial Overgrowth Metronidazole, Ciprofloxacin, Placebo - Small Intestinal Bacterial Overgrowth | Phase 4 | Unknown | San Antonio Military Medical Center | 180 | 2015-01-01 | 2015-06-01 |
| Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy cephalosporins, Fluoroquinolones, Clindamycin - Kidney Stones | Phase 3 | Completed | Northwell Health | 98 | 2014-09-01 | 2023-09-06 |
| Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Sitafloxacin, Ertapenem - Infection Due to Escherichia Coli, Acute Pyelonephritis | Phase 2 | Unknown | Mahidol University | 96 | 2012-11-01 | 2015-09-02 |
| Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection VANCOMYCIN, CEFTRIAXONE, CLINDAMYCIN - Hip Prosthetic Joint Infection | Phase 2 | Unknown | University Hospital, Tours | 100 | 2012-10-01 | 2014-05-28 |
| Treatment's Duration of Acute Uncomplicated Pyelonephritis levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones) - Urinary Tract Infection, Fever | Phase 4 | Completed | Assistance Publique - Hôpitaux de Paris | 310 | 2009-06-01 | 2014-11-06 |
| Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation ciprofloxacin, trimethoprim-sulfamethoxazole - Chronic Obstructive Pulmonary Disease, Sepsis | Phase 3 | Completed | University of Monastir | 170 | 2002-07-01 | 2020-02-24 |
Urinary Tract Infections (4) · AIDS-Related Opportunistic Infections (1) · Aortic Dissection (1) · Bronchitis (1) · Communicable Diseases (1) · Community-Acquired Pneumonia (1) · Endocarditis (1) · Escherichia coli Infections (1) · Fever (1) · Keratitis (1) · Kidney Calculi (1) · Leukemia (1) · Leukemia, Myeloid, Acute (1) · Pulmonary Disease, Chronic Obstructive (1) · Retinal Detachment (1)
Janssen Research & Development, LLC (2) · University Hospital, Tours (2) · Assistance Publique - Hôpitaux de Paris (1) · Egyptian Biomedical Research Network (1) · Haiphong University of Medicine and Pharmacy (1) · Mahidol University (1) · Northwell Health (1) · Qingfeng Pharmaceutical Group (1) · San Antonio Military Medical Center (1) · Shanghai Public Health Clinical Center (1) · St. Jude Children's Research Hospital (1) · Tan Tock Seng Hospital (1) · University Hospital, Geneva (1) · University of Monastir (1) · Wake Forest University Health Sciences (1)
United States (5) · France (3) · Italy (2) · Spain (2) · Australia (1) · China (1) · Greece (1) · Israel (1) · Lebanon (1) · Malaysia (1) · Saudi Arabia (1) · Singapore (1) · South Korea (1) · Switzerland (1) · Taiwan (1)
Bin Cao, Professor (1) · Bo Liu, Professor (1) · Chen Wang, Professor (1) · David Lye, MBBS (1) · Farhad Hafezi, MD, PhD (1) · Hong Fan, Professor (1) · Jie Cao, Professor (1)
PMID 20536364, PMID 32557558, PMID 32665381, PMID 34398907, PMID 34996516, PMID 36201545, PMID 37578113, PMID 41489779