9 completed. 9 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 9 |
| Phase 3 | 1 | Completed 1 |
Follow Contracture: new trials by email Literature Review of Contracture trials Research Report on Contracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy, Safety, and Tolerability, of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis EN3835, Placebo - Plantar Fibromatosis | Phase 2 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 176 | 2021-11-29 | 2026-03-27 |
| Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Oxycodone Hcl 5Mg, Ibuprofen 400 mg, Acetaminophen 650 mg - Carpal Tunnel Syndrome, Dupuytren Contracture | Phase 2 | Completed | University of Southern California | 40 | 2017-04-24 | 2019-09-26 |
| Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness Real soft splint (6 cm), Placebo soft splint (1 cm) - Brain Injuries, Disorder of Consciousness | Phase 2 | Completed | Géraldine Martens | 12 | 2017-01-01 | 2019-09-25 |
| Repurposing Anti-TNF for Treating Dupuytren's Disease Adalimumab, Saline - Dupuytren's Disease | Phase 2 | Completed | University of Oxford | 140 | 2016-03-02 | 2024-06-28 |
| Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules Collagenase clostridium histolyticum, Placebo - Dupuytren's Disease | Phase 2 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 76 | 2014-07-01 | 2017-10-05 |
| Investigations of Mechanisms and Treatment in Post-traumatic Joint Contractures Ketotifen, Placebo - Joint Contractures | Phase 2 | Completed | University of Calgary | 152 | 2013-06-01 | 2018-03-27 |
| Early Use of Botulinum Toxin in Spasticity Post Stroke. onabotulinumtoxinA, Placebo - Stroke, Muscle Spasticity | Phase 2 | Completed | Sandwell & West Birmingham Hospitals NHS Trust | 120 | 2012-01-01 | 2014-11-18 |
| Evaluation of the Efficiency of Autologous Platelet Gel (Platelet Rich Fibrin) Obtained From Own Patients' Blood Versus Vaselitulle in Dupuytren's Disease Postoperative Wound Healing Autologous platelets gel, Vaselitulle - Dupuytren's Contracture | Phase 2 / Phase 3 | Completed | Centre Hospitalier Universitaire de Nice | 80 | 2007-08-01 | 2012-03-20 |
| Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease collagenase - Dupuytren's Contracture | Phase 2 | Completed | State University of New York | 36 | 1995-08-01 | 2015-03-25 |
Dupuytren Contracture (5) · Stroke (2) · Arthritis (1) · Brain Injuries (1) · Carpal Tunnel Syndrome (1) · Central Nervous System Diseases (1) · Connective Tissue Diseases (1) · Consciousness Disorders (1) · Craniocerebral Trauma (1) · De Quervain Disease (1) · Fibromatosis, Plantar (1) · Fractures, Bone (1) · Ganglion Cysts (1) · Joint Dislocations (1)
Muscular Diseases (9) · Musculoskeletal Diseases (9) · Fibroma (6) · Neoplasms (6) · Neoplasms by Histologic Type (6) · Neoplasms, Connective Tissue (6) · Neoplasms, Connective and Soft Tissue (6) · Neoplasms, Fibrous Tissue (6) · Skin and Connective Tissue Diseases (6) · Connective Tissue Diseases (5) · Joint Diseases (4) · Nervous System Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Wounds and Injuries (3)
Acetaminophen (1) · Adalimumab (1) · Botulinum Toxins, Type A (1) · Collagenases (1) · Ibuprofen (1) · Ketotifen (1) · Microbial Collagenase (1) · Oxycodone (1) · Sodium Chloride (1) · xiapex (1)
Endo USA Inc., a Keenova Therapeutics Company (2) · Centre Hospitalier Universitaire de Nice (1) · Géraldine Martens (1) · Sandwell & West Birmingham Hospitals NHS Trust (1) · State University of New York (1) · University of Calgary (1) · University of Oxford (1) · University of Southern California (1)
United States (4) · United Kingdom (2) · Australia (1) · Belgium (1) · Canada (1) · France (1) · Netherlands (1)
Alidad Ghiassi, MD (1) · Anand D Pandyan, PhD (1) · Jagdeep Nanchahal, PhD FRCS (1) · Kevin Hildebrand, MD (1) · Lawrence C. Hurst (1) · Luis Ortega, MD (1) · Nicolas Lejeune (1) · Stephen G Sturman, MB ChB (1) · Veronica Urdaneta, MD MPH (1)
PMID 23190833, PMID 28854973, PMID 29983350, PMID 32639394, PMID 33040610, PMID 35949922, PMID 36325678, PMID 36378072
2015 (1)