11 completed, 3 recruiting, 3 unknown, 2 active not recruiting. 19 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 11, Recruiting 3, Unknown 3, Active not recruiting 2 |
Follow Cold Exposure: new trials by email Literature Review of Cold Exposure trials Research Report on Cold Exposure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Energy Dense Fueling for Cold-Weather Operations High Fat, High Carbohydrate - Cold Exposure | Not applicable | Recruiting | United States Army Research Institute of Environmental Medicine | 8 | 2026-02-14 | 2026-03-24 |
| Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity Caffeine (200 mg), Placebo - Brown Adipose Tissue (BAT) Physiology, Cold Exposure | Not applicable | Completed | University Hospital, Basel, Switzerland | 12 | 2026-01-21 | 2026-07-31 |
| Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia Cooling, Biopsies, Injection of 18F-FDG - Brown Adipose Tissue, Cold Exposure | Not applicable | Recruiting | University of Edinburgh | 12 | 2025-05-01 | 2026-06-30 |
| Effect of Pre-cooling on Whole-body Heat Loss During Exercise-heat Stress No Cooling, Pre-Cooling - Thermoregulation, Cold Exposure | Not applicable | Completed | University of Ottawa | 10 | 2024-10-24 | 2025-06-17 |
| Cold Water Exposure's Effects on Physical and Mental Health Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS) - Cold Exposure | Not applicable | Completed | University of Northern Colorado | 36 | 2024-10-10 | 2026-09-30 |
| The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold Mitoquinone mesylate (MitoQ), Placebo, Cold Water Hand Immersion - Cold Exposure | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 26 | 2024-09-16 | 2026-04-30 |
| Thermogenic Silencer Regulatory Factors in Humans Cold Vest Exposure Period, Rewarming Exposure Period, Fasting - Obesity, Metabolic Disease | Not applicable | Active not recruiting | Rockefeller University | 80 | 2024-08-16 | 2026-09-14 |
| The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function. TruBeet inorganic beetroot juice, Caffeine, Cold pressor test - Nitrate, Caffeine | Not applicable | Completed | Loughborough University | 24 | 2023-12-05 | 2025-09-12 |
| Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure Fish Oil, Placebo - Cold Exposure | Not applicable | Recruiting | Indiana University | 30 | 2023-06-12 | 2026-05-26 |
| The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults Repeated cold exposure - Cold Exposure | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 16 | 2022-08-01 | 2025-12-26 |
| The Effectiveness of the Wim Hof Method Wim Hof Method - Healthy, Blood Pressure | Not applicable | Completed | University of Bern | 42 | 2022-05-01 | 2023-06-08 |
| Cold, Appetite and Weight Loss in Individuals With Obesity Caloric Restriction, Cold intervention - Weight Loss, Cold Exposure | Not applicable | Unknown | University of Ottawa | 78 | 2022-02-01 | 2022-04-27 |
| Effects of Physical Training in Altered Environmental Conditions on Exercise Performance exercise and environmental conditions - Hypoxia, Altitude, Cold Exposure | Not applicable | Unknown | University School of Physical Education, Krakow, Poland | 128 | 2022-01-01 | 2023-12-13 |
| The Effect of Cold Exposure on Energy Expenditure Cold exposure - Cold Exposure | Not applicable | Completed | Maastricht University | 26 | 2021-05-17 | 2022-07-28 |
| Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion - Calorie Deficiency, Fasting | Not applicable | Completed | Lithuanian Sports University | 80 | 2021-02-08 | 2024-07-15 |
| Cocoa-rich Bioflavanol Supplementation Effects During Cold Exposure CocoaVia supplement, Placebo Pill - Cold Exposure, Manual Dexterity | Not applicable | Unknown | United States Army Research Institute of Environmental Medicine | 40 | 2020-01-13 | 2021-04-30 |
| Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT). Winter Swimming, Control group - Adipose Tissue, Brown, Brown Adipose Tissue | Not applicable | Active not recruiting | Kristian Karstoft | 30 | 2018-11-07 | 2025-08-17 |
| Hand Cooling With Ice Packs in Healthy Young Men Ice Pack (Localized Cryotherapy), Thermoneutral Water Pack (Control) - Cold Exposure, Body Temperature Regulation | Not applicable | Completed | Poznan University of Physical Education | 39 | 2018-04-12 | 2025-11-28 |
| Effects of Cold Exposure and Breathing Techniques on Immune Response Cold Exposure, Strength Ventilation - Cold Exposure, Hyperventilation | Not applicable | Completed | Radboud University Medical Center | 48 | 2016-04-12 | 2019-04-01 |
Obesity (3) · Motor Activity (2) · Weight Loss (2) · Altitude Sickness (1) · Appetitive Behavior (1) · Common Cold (1) · Diabetes Mellitus, Type 2 (1) · Endotoxemia (1) · Fasting (1) · Heat Stress Disorders (1) · Hyperventilation (1) · Inflammation (1) · Metabolic Diseases (1) · Multiple Endocrine Neoplasia Type 1 (1) · Starvation (1)
Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Behavior (4) · Body Weight (4) · Nutrition Disorders (4) · Nutritional and Metabolic Diseases (4) · Overnutrition (3) · Overweight (3) · Respiratory Tract Diseases (3) · Body Weight Changes (2) · Endocrine System Diseases (2) · Infections (2) · Respiration Disorders (2) · Bacteremia (1) · Behavior, Animal (1)
Caffeine (2) · Angptl4 protein, mouse (1) · Biopsy (1) · Caloric Restriction (1) · Calorimetry, Indirect (1) · Control Groups (1) · Cool-Down Exercise (1) · Diet, High-Fat (1) · Diet, High-Protein Low-Carbohydrate (1) · Exercise (1) · Fish Oils (1) · mitoquinone (1)
United States Army Research Institute of Environmental Medicine (4) · University of Ottawa (2) · Indiana University (1) · Kristian Karstoft (1) · Lithuanian Sports University (1) · Loughborough University (1) · Maastricht University (1) · Poznan University of Physical Education (1) · Radboud University Medical Center (1) · Rockefeller University (1) · University Hospital, Basel, Switzerland (1) · University School of Physical Education, Krakow, Poland (1) · University of Bern (1) · University of Edinburgh (1) · University of Northern Colorado (1)
United States (7) · Canada (2) · Netherlands (2) · Poland (2) · Switzerland (2) · United Kingdom (2) · Denmark (1) · Lithuania (1)
Billie K Alba, Ph.D. (1) · Eric Doucet, PhD (1) · Glen P Kenny, PhD (1) · Jelle Zwaag, MSc (1) · Joeva Barrow, Ph.D., R.D. (1) · John W Castellani, PhD (1) · Marcin Maciejczyk, Prof. dr (1) · Matthias Betz, Prof. (1) · Paul Cohen, Ph.D., M.D. (1) · Pawel P Korman, PhD (1) · Sascha Ketelhut, PhD (1) · Stephen Bailey (1)
PMID 35213875, PMID 38108909, PMID 38150009, PMID 40067458, PMID 40410569, PMID 40670486, PMID 41484413, PMID 42323358