116 completed, 19 terminated, 11 active not recruiting, 9 recruiting. 47 Phase 1, 45 Not applicable, 25 Phase 2, 11 Early Phase 1, 6 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma Intratumoral 2141-V11, Nivolumab, Fluoropyrimidine - Esophageal Cancer, Advanced Esophageal Cancer | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 30 | 2026-09-04 | 2026-09-14 |
| First-in-Human Study Testing a New Antibody Treatment for Tick-Borne Encephalitis in Healthy Volunteers. Human monoclonal antibody TBE025, intravenous infusion - The Tick-borne Encephalitis Virus (TBEV) | Phase 1 | Not yet recruiting | Giuseppe Pantaleo | 18 | 2026-01-01 | 2026-01-29 |
| The Impact of Time Restricted Eating on Type 2 Diabetes Meal timing, Time restricted eating, Usual feeding pattern. - Type 2 Diabetes | Not applicable | Terminated | Rockefeller University | 2 | 2025-05-29 | 2026-01-20 |
| D2C7-IT + 2141-V11 Combination Post-resection in rGBM D2C7-IT, 2141 V11 - Recurrent Glioblastoma IDH Wildtype | Phase 1 | Recruiting | Darell Bigner | 46 | 2025-03-17 | 2026-10-21 |
| Thermogenic Silencer Regulatory Factors in Humans Cold Vest Exposure Period, Rewarming Exposure Period, Fasting - Obesity, Metabolic Disease | Not applicable | Active not recruiting | Rockefeller University | 80 | 2024-08-16 | 2026-09-14 |
| HepB mAb19 in Individuals With Chronic Hepatitis B Infection HepB mAb19, Sterile Saline - Hepatitis b Virus, Hepatitis B | Phase 1 | Active not recruiting | Rockefeller University | 37 | 2024-04-25 | 2026-10-13 |
| Myokine Identification Following Acute Exercise Exercise - Adiposity | Not applicable | Completed | Rockefeller University | 12 | 2024-04-18 | 2025-03-10 |
| Phase II Trial of ART + Dual bNAbs vs. ART + Placebo During Primary HIV-1 Infection-impact on Post-ART Control Recombinant human monoclonal antibody (bNAbs), Placebo - HIV/AIDS and Infections | Phase 2 | Recruiting | ANRS, Emerging Infectious Diseases | 69 | 2024-04-11 | 2024-12-27 |
| Compassion-Based Resiliency Training (CBRT) Intervention on Racism-based Stress Contemplative-Based Resilience Training (CBRT) - Racism, Stress, Psychological | Not applicable | Completed | Rockefeller University | 22 | 2024-02-15 | 2026-04-09 |
| Broadly Neutralizing Antibodies 3BNC117-LS & 10-1074-LS to Prevent Relapse During ATI 3BNC117-LS, 10-1074-LS - HIV Infections | Phase 1 | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2024-01-01 | 2023-09-07 | |
| Resilience in East Asian Immigrants for Advance Care Planning Discussions Culturally Tailored Digital Resilience-Building, Semi-structured interviews - Neoplasms, Advance Care Planning | Completed | University of Illinois at Chicago | 76 | 2023-10-27 | 2026-07-07 | |
| D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients D2C7-IT, 2141-V11 - Newly Diagnosed MGMT Unmethylated Glioblastoma | Phase 1 / Phase 2 | Recruiting | Darell Bigner | 50 | 2023-09-06 | 2026-10-16 |
| Effect of Antibiotics on Enteric Neurons and Glia Amoxicillin Oral Capsule - Antibiotic Enterocolitis | Phase 4 | Completed | Rockefeller University | 10 | 2023-06-23 | 2026-03-12 |
| Predictors of Aspirin Failure in Preeclampsia Prevention Aspirin - Preeclampsia | Early Phase 1 | Recruiting | Rockefeller University | 130 | 2023-04-13 | 2025-10-30 |
| HBV Vaccination of Healthy Volunteers to Evaluate the Composition of Germinal Centers Hepatitis B Vaccine (Recombinant) - Hepatitis B | Phase 4 | Terminated | Rockefeller University | 9 | 2022-12-10 | 2026-04-16 |
| 3BNC117-LS and 10-1074-LS Plus N-803 (bNAb+N-803) 3BNC117-LS, 10-1074-LS, N803 - Human Immunodeficiency Virus | Phase 1 | Completed | Rockefeller University | 28 | 2022-12-07 | 2026-03-31 |
| Racism-based and Biomarkers of Stress Racism, Stress, Psychological | Completed | Rockefeller University | 20 | 2022-10-31 | 2023-05-11 | |
| Study of 2141-V11 in People With Non-muscle Invasive Bladder Cancer That Did Not Respond to Standard Treatment anti-CD40 antibody 2141-V11, Intravesical Gemcitabine, Intravesical Gemcitabine with anti-CD40 antibody 2141-V11 - Non-muscle Invasive Bladder Cancer | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 115 | 2021-11-08 | 2026-08-14 |
| BATokines as Biomarkers of Brown Fat in Humans Cooling Vest Procedure, Fasting overnight - Healthy Lifestyle | Not applicable | Active not recruiting | Rockefeller University | 20 | 2021-10-12 | 2026-05-27 |
| Molecular Characteristics of Brodalumab in Hidradenitis Suppurativa Brodalumab - Hidradenitis Suppurativa, Acne Inversa | Early Phase 1 | Completed | Rockefeller University | 4 | 2021-08-05 | 2022-07-27 |
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Obesity (21) · Acquired Immunodeficiency Syndrome (14) · HIV Infections (14) · Psoriasis (8) · Hepatitis C (7) · Dermatitis, Atopic (5) · Insulin Resistance (5) · Metabolic Syndrome (5) · Neoplasms (5) · Weight Loss (5) · Eczema (4) · Glioblastoma (4) · Hidradenitis Suppurativa (4) · Melanoma (4) · Rare Diseases (4)
Antibodies, Monoclonal (7) · 3BNC117 antibody (6) · Cholecalciferol (4) · Broadly Neutralizing Antibodies (3) · Cyclosporine (3) · D2C7-(scdsFv)-PE38KDEL (3) · Hepatitis B Vaccines (3) · brodalumab (3) · poly ICLC (3) · ALT-803 (2) · Blood Specimen Collection (2) · Calcium (2) · Daclizumab (2) · Diet Therapy (2) · Etanercept (2)
United States (155) · Germany (4) · Denmark (2) · United Kingdom (2) · Australia (1) · Brazil (1) · France (1) · Kenya (1) · Netherlands (1) · Rwanda (1) · South Africa (1) · Switzerland (1) · Uganda (1)
Marina Caskey, MD (16) · Martin Markowitz, MD (6) · Peter Holt, MD (6) · James Krueger, MD (3) · John W Frew, MD (3) · Robert Darnell, MD, PhD (3) · Attallah Kappas (2) · Emma Guttman, MD,PhD (2) · James Krueger, MD, PHD (2) · James Krueger, MD, PhD (2) · James Young, MD (2) · Jan L. Breslow, MD (2) · Lisa C. Hudgins, MD (2) · Lisa Neff, MD (2) · Manish Ponda, MD (2)
PMID 32838558, PMID 25475068, PMID 21252253, PMID 17942751, PMID 19919714, PMID 20824184, PMID 21034448, PMID 21321062, PMID 21355077, PMID 21421840, PMID 21603651, PMID 22348003, PMID 22566506, PMID 22947589, PMID 24067879, PMID 24209977, PMID 24720702, PMID 27009752, PMID 27199429, PMID 27521361, PMID 28179273, PMID 28228421, PMID 28740869, PMID 28874545, PMID 30176893, PMID 31393868, PMID 31851762, PMID 32555388, PMID 33548397, PMID 33664689, PMID 34145880, PMID 34344873, PMID 34460948, PMID 34473343, PMID 34746196, PMID 35342110, PMID 35544074, PMID 35710741, PMID 35752539, PMID 35979886, PMID 36075585, PMID 36753564, PMID 37837376, PMID 38628675, PMID 38883779, PMID 41326736, PMID 42202839, PMID 42444466, PMID 42744897
U19AI111825 (3), U01AI145921 (2), 2019 (1), R01AI060561 (1), R01DA033777 (1), R01HL019278 (1), U01AI118536 (1), UM1AI126620 (1), UM1AI164560 (1)