15 completed, 6 recruiting, 4 unknown, 2 active not recruiting. 19 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 11, Recruiting 3, Unknown 3, Active not recruiting 2 |
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 1 | Recruiting 1 |
Follow Cold Exposure: new trials by email Literature Review of Cold Exposure trials Research Report on Cold Exposure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cold-Region Exposure and Cardiac Remodeling After PCI Coronary Artery Disease, Percutaneous Coronary Intervention (PCI) | Recruiting | Chinese PLA General Hospital | 400 | 2026-06-30 | 2026-08-19 | |
| Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS) Controlled Cold Exposure, Investigator-Selected Standard PD-1/PD-L1 Inhibitor-Based Therapy - Solid Tumors, Solid Malignancies | Phase 1 | Recruiting | West China Hospital | 24 | 2026-04-20 | 2026-05-28 |
| Energy Dense Fueling for Cold-Weather Operations High Fat, High Carbohydrate - Cold Exposure | Not applicable | Recruiting | United States Army Research Institute of Environmental Medicine | 8 | 2026-02-14 | 2026-03-24 |
| Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity Caffeine (200 mg), Placebo - Brown Adipose Tissue (BAT) Physiology, Cold Exposure | Not applicable | Completed | University Hospital, Basel, Switzerland | 12 | 2026-01-21 | 2026-07-31 |
| Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia Cooling, Biopsies, Injection of 18F-FDG - Brown Adipose Tissue, Cold Exposure | Not applicable | Recruiting | University of Edinburgh | 12 | 2025-05-01 | 2026-06-30 |
| Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel Modafinil (M), 200 mg Microcrystalline Cellulose - Sleep Deprivation, Cold Exposure | Phase 4 | Recruiting | United States Army Research Institute of Environmental Medicine | 33 | 2025-02-18 | 2026-09-21 |
| Effect of Pre-cooling on Whole-body Heat Loss During Exercise-heat Stress No Cooling, Pre-Cooling - Thermoregulation, Cold Exposure | Not applicable | Completed | University of Ottawa | 10 | 2024-10-24 | 2025-06-17 |
| Cold Water Exposure's Effects on Physical and Mental Health Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS) - Cold Exposure | Not applicable | Completed | University of Northern Colorado | 36 | 2024-10-10 | 2026-09-30 |
| The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold Mitoquinone mesylate (MitoQ), Placebo, Cold Water Hand Immersion - Cold Exposure | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 26 | 2024-09-16 | 2026-04-30 |
| Thermogenic Silencer Regulatory Factors in Humans Cold Vest Exposure Period, Rewarming Exposure Period, Fasting - Obesity, Metabolic Disease | Not applicable | Active not recruiting | Rockefeller University | 80 | 2024-08-16 | 2026-09-14 |
| The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function. TruBeet inorganic beetroot juice, Caffeine, Cold pressor test - Nitrate, Caffeine | Not applicable | Completed | Loughborough University | 24 | 2023-12-05 | 2025-09-12 |
| Simulation Study on Advanced Medical Procedures Under Extreme Environments Cold Exposure | Completed | Institute of Mountain Emergency Medicine | 36 | 2023-10-16 | 2024-10-16 | |
| Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure Fish Oil, Placebo - Cold Exposure | Not applicable | Recruiting | Indiana University | 30 | 2023-06-12 | 2026-05-26 |
| Assessment of the Effects of a 24-hour Cold and Heat Exposure on the Factors Influencing Food Intake Heat exposure (32°C), Cold exposure (16°C), Thermoneutral exposure (24°C) - Eating Habit, Cold Exposure | Unknown | Direction Centrale du Service de Santé des Armées | 24 | 2022-11-28 | 2022-12-09 | |
| The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults Repeated cold exposure - Cold Exposure | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 16 | 2022-08-01 | 2025-12-26 |
| Oxytocin on Cold Water Task Performance and Recovery Oxytocin nasal spray, Placebo nasal spray - Cold Exposure | Phase 2 | Completed | Florida Institute for Human and Machine Cognition | 17 | 2022-05-20 | 2026-04-03 |
| The Effectiveness of the Wim Hof Method Wim Hof Method - Healthy, Blood Pressure | Not applicable | Completed | University of Bern | 42 | 2022-05-01 | 2023-06-08 |
| Cold, Appetite and Weight Loss in Individuals With Obesity Caloric Restriction, Cold intervention - Weight Loss, Cold Exposure | Not applicable | Unknown | University of Ottawa | 78 | 2022-02-01 | 2022-04-27 |
| Effects of Physical Training in Altered Environmental Conditions on Exercise Performance exercise and environmental conditions - Hypoxia, Altitude, Cold Exposure | Not applicable | Unknown | University School of Physical Education, Krakow, Poland | 128 | 2022-01-01 | 2023-12-13 |
| The Effect of Cold Exposure on Energy Expenditure Cold exposure - Cold Exposure | Not applicable | Completed | Maastricht University | 26 | 2021-05-17 | 2022-07-28 |
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Motor Activity (3) · Obesity (3) · Common Cold (2) · Weight Loss (2) · Altitude Sickness (1) · Appetitive Behavior (1) · Coronary Artery Disease (1) · Diabetes Mellitus, Type 2 (1) · Endotoxemia (1) · Fasting (1) · Feeding Behavior (1) · Heat Stress Disorders (1) · Hyperventilation (1) · Inflammation (1) · Metabolic Diseases (1)
Pathological Conditions, Signs and Symptoms (7) · Behavior (6) · Signs and Symptoms (6) · Body Weight (4) · Nutrition Disorders (4) · Nutritional and Metabolic Diseases (4) · Respiratory Tract Diseases (4) · Infections (3) · Overnutrition (3) · Overweight (3) · Behavior, Animal (2) · Body Weight Changes (2) · Endocrine System Diseases (2) · Picornaviridae Infections (2) · RNA Virus Infections (2)
Caffeine (2) · Angptl4 protein, mouse (1) · Biopsy (1) · Caloric Restriction (1) · Calorimetry, Indirect (1) · Control Groups (1) · Cool-Down Exercise (1) · Diet, High-Fat (1) · Diet, High-Protein Low-Carbohydrate (1) · Electric Stimulation Therapy (1) · Exercise (1) · Fish Oils (1) · Modafinil (1) · Oxytocin (1) · Transcutaneous Electric Nerve Stimulation (1)
United States Army Research Institute of Environmental Medicine (5) · University School of Physical Education, Krakow, Poland (2) · University of Ottawa (2) · Chinese PLA General Hospital (1) · Direction Centrale du Service de Santé des Armées (1) · Florida Institute for Human and Machine Cognition (1) · Indiana University (1) · Institute of Mountain Emergency Medicine (1) · Kristian Karstoft (1) · Lithuanian Sports University (1) · Loughborough University (1) · Maastricht University (1) · Poznan University of Physical Education (1) · Radboud University Medical Center (1) · Rockefeller University (1)
United States (9) · Poland (3) · Canada (2) · China (2) · Netherlands (2) · Switzerland (2) · United Kingdom (2) · Brazil (1) · Denmark (1) · France (1) · Italy (1) · Lithuania (1)
Aneta Teleglow (1) · Billie K Alba, Ph.D. (1) · Eric Doucet, PhD (1) · Glen P Kenny, PhD (1) · Jelle Zwaag, MSc (1) · Joeva Barrow, Ph.D., R.D. (1) · John W Castellani, PhD (1) · Marcas Bamman, Ph.D. (1) · Marcin Maciejczyk, Prof. dr (1) · Matthias Betz, Prof. (1) · Paul Cohen, Ph.D., M.D. (1) · Pawel P Korman, PhD (1)
PMID 35213875, PMID 38108909, PMID 38150009, PMID 38907310, PMID 40067458, PMID 40410569, PMID 40670486, PMID 41484413, PMID 42323358