70 completed, 8 not yet recruiting, 8 recruiting, 4 unknown. 88 Not applicable, 2 Phase 4, 1 Phase 2.
Follow Cognitive Performance: new trials by email Literature Review of Cognitive Performance trials Research Report on Cognitive Performance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Placebo Effect on Cycling Performance: Laboratory Crossover Study Caffeine (6mg/kg), Placebo (Starch capsule) - Physical Performance, Placebo Effect | Not applicable | Not yet recruiting | Poznan University of Physical Education | 80 | 2027-01-01 | 2026-09-18 |
| Predicting Declines in Attention and Memory During a Prolonged Mental Task Individually Calibrated Time Load Dual-back Task With Seated Rest - Mental Fatigue, Cognitive Performance | Not applicable | Not yet recruiting | DSW Ideis University | 250 | 2026-12-01 | 2026-10-16 |
| SJFT Performance, Inhibitory Control, and Attention in Young Judokas Special Judo Fitness Test (SJFT) - Cognitive Performance, Inhibitory Control | Not applicable | Not yet recruiting | Bogazici University | 120 | 2026-09-15 | 2026-09-01 |
| Acute Effects of Active Breaks and Physically Active Learning in University Students Sedentary Academic Review, Active Break, Physically Active Learning - Cognitive Performance, Academic Performance | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 700 | 2026-09-15 | 2026-09-10 |
| Placebo Effect in Field-Based Physical Performance Caffeine (6mg/kg), Placebo (Starch capsule), Sham (No Treatment) - Physical Performance, Placebo Effect | Not applicable | Not yet recruiting | Poznan University of Physical Education | 120 | 2026-09-01 | 2026-08-03 |
| Effects of Caffeine on Chess Performance and Cognitive Function in Professional Chess Players Caffeinated Coffee, Decaffeinated Coffee Placebo - Cognitive Performance, Attention | Not applicable | Recruiting | St. Louis University | 12 | 2026-08-25 | 2026-09-30 |
| Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players Placebo, Taurine Plus Caffeine, Taurine, Caffeine, and Phosphatidylserine - Mental Fatigue, Cognitive Performance | Not applicable | Completed | Vizja University in Warsaw | 65 | 2026-08-06 | 2026-09-14 |
| A Clinical Trial to Investigate the Safety and Efficacy of AP-Brain on Cognitive Performance at Varying Dosages in Healthy Middle-aged and Older Adults With Self-reported Memory Problems AP-Brain (1g), AP-Brain (3g), AP-Brain (5g) - Cognition, Cognitive Performance | Not applicable | Recruiting | Rousselot BVBA | 120 | 2026-07-15 | 2026-09-18 |
| Cognitive Responses to Acute Breath-Hold Diving Training in Female Divers Land-Based Breath-Hold Training, Water-Based Breath-Hold Training, Control Session - Sport Physiology, Cognitive Performance | Not applicable | Not yet recruiting | Istanbul Gelisim University | 30 | 2026-06-01 | 2026-06-01 |
| Acute Effects of Moderate-Intensity Swimming Exercise on Inhibitory Control, Cognitive Flexibility, and Selective Attention Moderate-Intensity Freestyle Swimming Exercise - Executive Function, Cognitive Performance | Not applicable | Completed | Görkem Açar | 60 | 2026-05-01 | 2026-06-26 |
| EEG-Guided Binaural Beat Audio to Reduce Performance-Related Stress and Improve Cognition EEG-guided binaural beat audio, Non-binaural audio intervention - Cognitive Abilities, Performance | Not applicable | Recruiting | Texas Tech University Health Sciences Center | 32 | 2026-04-07 | 2026-08-24 |
| Examining the Efficacy of Short-Term Intensive PTSD Treatment on Psychological and Cognitive Impairment Symptoms Cognitive Processing Therapy, Eye-Movement Desensitization and Reprocessing - PTSD, Cognitive Performance | Not applicable | Recruiting | Ohio State University | 120 | 2026-04-01 | 2026-07-02 |
| Visual Stimulus-Based Cognitive-Motor Agility Exercise in Older Adults Multicomponent Exercise Program, Visual Stimulus-Based Cognitive-Motor Agility Exercise, Time-Matched Low-Intensity Activities - Aging, Cognitive Performance | Not applicable | Completed | Çanakkale Onsekiz Mart University | 41 | 2026-04-01 | 2026-07-21 |
| L-serine and Strength Training in the Elderly Strength training, L-serine supplementation, Control (cornstarch) - Brain Health, Longevity | Not applicable | Recruiting | University of Vienna | 126 | 2026-03-01 | 2026-03-12 |
| Effects of Different Doses of Caffeine on Physical and Cognitive Performance in Female Handball Players Caffeine 3 mg/kg, Caffeine 6 mg/kg, Placebo - Athletic Performance, Cognitive Performance | Not applicable | Completed | Sinop University | 20 | 2026-01-25 | 2026-05-01 |
| High-Dairy Food Patterns and Gut-Brain Axis High-dairy food pattern, Low-dairy food pattern - Brain Insulin Sensitivity, Brain Vascular Function | Not applicable | Not yet recruiting | Maastricht University Medical Center | 40 | 2025-12-22 | 2026-01-21 |
| A Clinical Trial to Evaluate the Effects of Two Supplements on Cognitive Function, Cognitive Performance, and Mood BrainJuice Supplement - Cognitive Function, Cognitive Performance | Not applicable | Completed | BrainJuice | 30 | 2025-11-09 | 2026-08-14 |
| Acute Effects of Moderate-Intensity Continuous Exercise Versus HIIT on Cognitive Performance and Psychophysiological Responses in Physically Active Adults Moderate-Intensity Continuous Exercise (MICE), High-Intensity Interval Training (HIIT) - Sustained Attention, Cognitive Performance | Not applicable | Enrolling by invitation | Qassim University | 38 | 2025-10-01 | 2026-02-10 |
| Effects of L-Theanine and Hericium Erinaceus Gummies on Psychological, Cognitive, and Sleep Quality in University Students gummy intervention - Psychological Stress, Anxiety | Not applicable | Completed | University of Nottingham Malaysia | 67 | 2025-10-01 | 2026-06-24 |
| Long-Term Effects of Walnut Consumption on Brain Function Walnuts - Healthy, Brain Insulin Sensitivity | Not applicable | Recruiting | Maastricht University Medical Center | 55 | 2025-10-01 | 2026-07-24 |
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Motor Activity (9) · Mental Fatigue (6) · Sleep Initiation and Maintenance Disorders (3) · Anxiety Disorders (2) · Cognitive Dysfunction (2) · Dehydration (2) · Psychological Well-Being (2) · Stress Disorders, Traumatic, Acute (2) · Anemia, Iron-Deficiency (1) · Body Weight (1) · Body Weight Changes (1) · Bone Diseases, Metabolic (1) · COVID-19 (1) · Cognition Disorders (1) · Depression (1)
Behavior (21) · Pathological Conditions, Signs and Symptoms (11) · Mental Disorders (10) · Signs and Symptoms (9) · Behavioral Symptoms (7) · Fatigue (6) · Nutritional and Metabolic Diseases (6) · Nervous System Diseases (5) · Metabolic Diseases (4) · Dyssomnias (3) · Neurocognitive Disorders (3) · Pathologic Processes (3) · Sleep Disorders, Intrinsic (3) · Sleep Wake Disorders (3) · Stress Disorders, Traumatic (3)
Caffeine (6) · Starch (3) · theanine (3) · Control Groups (2) · Dietary Supplements (2) · Exercise (2) · High-Intensity Interval Training (2) · Phosphatidylserines (2) · Resistance Training (2) · Taurine (2) · 2-cyclohexylidenhydrazo-4-phenyl-thiazole (1) · Arginine (1) · Blood Glucose (1) · Creatine (1) · Edible Grain (1)
Maastricht University Medical Center (8) · PepsiCo Global R&D (4) · Liquid I.V. (2) · National Institute of Nutrition and Seafood Research, Norway (2) · Poznan University of Physical Education (2) · Universidad Católica San Antonio de Murcia (2) · University of Florida (2) · Aksaray University Training and Research Hospital (1) · Ankara Yildirim Beyazıt University (1) · Arizona State University (1) · Atılım University (1) · Balikesir University (1) · Baylor Research Institute (1) · Bogazici University (1) · BrainJuice (1)
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Peter J Joris, PhD (4) · Ingvild Eide Graff, PhD (2) · Jakub Malik, PhD (2) · Ronald P Mensink, PhD (2) · Albert Vandenberg, PhD (1) · Ammal M Metwally, PhD (MD) (1) · Andrew A Guccione, PT, PhD, DPT (1) · Antje Heinrich, Doctorate (1) · Arja Uusitalo, MD (1) · Barbara R Cardoso, PhD (1) · Daniel Aeschbach, PhD (1) · Daniel J Lamport, PhD (1) · David Crowley (1)
PMID 16344363, PMID 18778321, PMID 21763472, PMID 25391155, PMID 28229114, PMID 28714768, PMID 28969711, PMID 29475446, PMID 29486547, PMID 29530020, PMID 29765853, PMID 30541572, PMID 31046819, PMID 31866855, PMID 31913135, PMID 32338756, PMID 33169699, PMID 33809544, PMID 33978160, PMID 34510189, PMID 34548089, PMID 35049605, PMID 35395555, PMID 37628548, PMID 38458577, PMID 38632364, PMID 39075543, PMID 39136270, PMID 39209968, PMID 41205298, PMID 41444702, PMID 41668720, PMID 42783813, PMID 42841520
2018 (1), R01AG060741 (1), R01HL077399 (1), R01MH060234 (1), R21AG077957 (1)