17 completed, 1 recruiting, 1 terminated, 1 unknown. 13 Not applicable, 3 Early Phase 1, 2 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 12, Unknown 1 |
| Early Phase 1 | 3 | Completed 2, Recruiting 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow theanine: new trials by email Literature Review of theanine trials Research Report on theanine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance Survey Administration, Theanine - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Early Phase 1 | Recruiting | City of Hope Medical Center | 50 | 2026-04-21 | 2026-05-08 |
| L-theanine and Paraxanthine for Cognitive Improvement in Adults With ADHD and ASD L-theanine and paraxanthine, Placebo - Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) | Not applicable | Completed | Texas Tech University Health Sciences Center | 17 | 2025-10-01 | 2026-08-24 |
| Effects of Caffeine and L-Theanine on Physical and Cognitive Performance in Trained Athletes Caffeine, L-theanine, Combined Caffeine and L-Theanine - Cognitive Performance, Physical Performance Enhancement | Not applicable | Completed | Ulaş Can YILDIRIM | 20 | 2025-08-01 | 2025-12-08 |
| Supplement Combination on Stress and Sleep All Active Supplement Combinations (Ashwagandha, Rhodiola rosea, magnesium threonate, L-theanine, and apigenin)), AM Active Supplement Combination (Ashwagandha and Rhodiola rosea), PM Active Supplement Combination (Magnesium threonate, L-theanine, and apigenin) - Healthy | Not applicable | Completed | University of South Carolina | 115 | 2025-02-15 | 2026-02-11 |
| Bonafide Sleep Supplement for Menopausal Women With Sleep Complaints S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate - Sleep Disturbance | Not applicable | Completed | Bonafide Health | 111 | 2025-01-03 | 2026-09-24 |
| Bonafide Sleep Supplement for Menopausal Women With Impaired Sleep S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate - Sleep Disturbances | Not applicable | Completed | Bonafide Health | 90 | 2025-01-03 | 2026-09-24 |
| Effects of a Theanine for Stress Relief Formulation in Individuals Who Report Occasional Moderate High Levels of Stress. Theanine for stress relief formulation, Placebo - Stress | Not applicable | Completed | Supplement Formulators, Inc. | 104 | 2023-02-09 | 2026-08-26 |
| Nutritional Intervention to Enhance Sleep Quality and Quantity in Athletes Trypophan, Theanine and 5'AMP, Placebo - Sleep, Physical Performance | Not applicable | Completed | PepsiCo Global R&D | 19 | 2022-03-14 | 2022-11-15 |
| A Study to Assess the Synergistic Effects of a Cranberry Beverage on Cognitive Function Cranberry Juice Product - Attention, Mood | Not applicable | Completed | Ocean Spray Cranberries, Inc. | 25 | 2021-07-26 | 2023-07-07 |
| Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study L-theanine, Placebo - Cortical Excitability, Psychiatric Disorder | Early Phase 1 | Completed | Butler Hospital | 11 | 2020-06-09 | 2021-09-23 |
| Assessing the Effectiveness of an N-of-1 Platform Using Study of Cognitive Enhancers L-theanine, Caffeine supplement, N1 app - Cognitive Performance | Phase 4 | Terminated | Icahn School of Medicine at Mount Sinai | 57 | 2019-10-18 | 2021-03-12 |
| Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder L-theanine, Caffeine, L-theanine-Caffeine Combination - Attention Deficit Hyperactivity Disorder | Early Phase 1 | Completed | Texas Tech University | 6 | 2018-05-14 | 2019-04-12 |
| Theanine and Caffeine on Neurophysiology of Attention Theanine, Caffeine, Theanine-Caffeine Combination - L-theanine | Not applicable | Completed | Texas Tech University | 9 | 2016-05-01 | 2016-09-02 |
| Tea Components, Mental Stress and Blood Pressure Combination of caffeine and theanine, Caffeine - Healthy | Not applicable | Completed | Unilever R&D | 56 | 2015-03-01 | 2015-12-04 |
| The Effect of the Amino Acid L-Theanine on Alertness and Vigilance L-theanine capsule, Placebo capsule - Theanine, (L)-Isomer | Not applicable | Completed | The University of Texas Health Science Center, Houston | 26 | 2011-11-01 | 2023-12-13 |
| Anti-stress Effect of Theanine on Students During Long-term Pharmacy Practices Theanine - Healthy Students | Not applicable | Completed | University of Shizuoka | 20 | 2011-05-01 | 2013-07-16 |
| Pregnenolone and L-theanine Augmentation in the Treatment for Schizophrenia and Schizoaffective Disorders Pregnenolone and L-Theanine, Placebo - Schizophrenia, Schizoaffective Disorder | Not applicable | Unknown | Sha'ar Menashe Mental Health Center | 60 | 2011-01-01 | 2013-12-05 |
| The Effects of Caffeine and L-theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood Caffeine and L-theanine - Cognitive Function, Mood | Phase 4 | Completed | Northumbria University | 24 | 2009-08-01 | 2010-07-23 |
| L-Theanine in the Management of Schizophrenia L-Theanine, Placebo - Schizophrenia | Phase 3 | Completed | Sha'ar Menashe Mental Health Center | 60 | 2006-10-01 | 2008-12-16 |
| Effects of L-Theanine in Boys With ADHD L-theanine - Attention Deficit Hyperactivity Disorder | Phase 2 | Completed | University of British Columbia | 100 | 2005-10-01 | 2008-05-06 |
Attention Deficit Disorder with Hyperactivity (3) · Sleep Initiation and Maintenance Disorders (3) · Parasomnias (2) · Psychotic Disorders (2) · Schizophrenia (2) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Burnout, Psychological (1) · Disorders of Excessive Somnolence (1) · Fatigue (1) · Mental Disorders (1) · Motor Activity (1) · Spasm (1)
Bonafide Health (2) · Sha'ar Menashe Mental Health Center (2) · Texas Tech University (2) · Butler Hospital (1) · City of Hope Medical Center (1) · Icahn School of Medicine at Mount Sinai (1) · Northumbria University (1) · Ocean Spray Cranberries, Inc. (1) · PepsiCo Global R&D (1) · Supplement Formulators, Inc. (1) · Texas Tech University Health Sciences Center (1) · The University of Texas Health Science Center, Houston (1) · Ulaş Can YILDIRIM (1) · Unilever R&D (1) · University of British Columbia (1)
United States (12) · United Kingdom (2) · Australia (1) · Canada (1) · Israel (1) · Japan (1) · Turkey (Türkiye) (1)
Michael S Ritsner, MD, PhD (2) · Trisha VanDusseldorp, PhD (2) · Alice Eggleston, PA-C, MPH (1) · Anatoly Gibel, MD (1) · Andrew Swick, PhD (1) · Chanaka Kahathuduwa, MBBS PhD (1) · Chanoch Miodownik, MD (1) · Crystal Haskell, PhD (1) · Dr. Michael Lyon (1) · Erica Veguilla (1) · Jason Bobe (1) · Linda Carpenter, MD (1) · Mark Hamer, Dr (1) · Martin Binks, PhD (1) · Shona Halson, PhD (1)
PMID 12062586, PMID 15272110, PMID 21208586, PMID 21617527, PMID 25360512, PMID 26218236, PMID 30999017, PMID 31287117, PMID 31758301, PMID 31913135, PMID 33782647, PMID 34293527, PMID 41668720, PMID 9566605
P30CA033572 (1)