51 completed, 16 recruiting, 5 active not recruiting, 5 unknown. 30 Not applicable, 18 Phase 2, 17 Phase 1, 14 Early Phase 1, 2 Phase 3.
Follow Cocaine Use Disorder: new trials by email Literature Review of Cocaine Use Disorder trials Research Report on Cocaine Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety Profile of Psilocybin for Cocaine Use Disorder Psilocybin - Cocaine Use Disorder | Early Phase 1 | Suspended | University of California, Los Angeles | 10 | 2029-02-01 | 2026-04-07 |
| Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder High Definition Transcranial Direct Current Stimulation - Cocaine Use Disorder | Not applicable | Recruiting | Virginia Commonwealth University | 36 | 2026-10-01 | 2026-09-28 |
| Imaging Mitochondrial Complex-I in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study [F-18]BCPP-EF - Cocaine Use Disorder, Healthy Controls Group - Age and Sex-matched | Early Phase 1 | Recruiting | Rajesh Narendran | 40 | 2026-09-04 | 2026-09-14 |
| An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder Tirzepatide - Obesity, Methamphetamine Use Disorder | Phase 2 | Active not recruiting | University of Texas Southwestern Medical Center | 45 | 2026-08-19 | 2026-10-29 |
| rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder Active H7-coil repetitive transcranial magnetic stimulation (rTMS), Sham H7-coil repetitive transcranial magnetic stimulation (rTMS) - Cocaine Use, Cocaine Dependence | Not applicable | Recruiting | New York State Psychiatric Institute | 30 | 2026-08-14 | 2026-10-22 |
| LDART for Stimulant Use Disorder LDART, Psychoeducational booklet - Stimulant Use Disorder, Cocaine Use Disorder | Not applicable | Enrolling by invitation | Yale University | 80 | 2026-04-29 | 2026-05-01 |
| Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder Sustained-release Dexamphetamine, Placebo - Cocaine Use Disorder | Phase 2 | Recruiting | Parnassia Addiction Research Centre | 204 | 2026-04-22 | 2026-05-29 |
| Impact of Cocaine Use and Withdrawal on Sleep Multimodal Sleep and Biomarker Assessment - Cocaine Use Disorder | Recruiting | Hôpital le Vinatier | 32 | 2026-03-19 | 2026-06-11 | |
| Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 240 | 2026-02-25 | 2026-10-13 |
| Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder clonidine, clonazepam 0,25 mg - Cocaine Use Disorder, Crack Abuse or Dependence | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 36 | 2026-01-28 | 2026-02-24 |
| Repurposing Semaglutide for the Treatment of Cocaine Use Disorder Semaglutide, Placebo, cognitive behavioral therapy (CBT). - Cocaine Use Disorder | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 75 | 2026-01-15 | 2026-03-19 |
| Cocaine and Pentoxifylline (BED IN 47) Placebo, Cocaine (IV), Pentoxifylline - Cocaine Use Disorder | Early Phase 1 | Recruiting | William Stoops | 30 | 2025-11-10 | 2026-06-08 |
| Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV Semaglutide, Placebo - Cocaine Use Disorder, HIV | Phase 2 | Active not recruiting | University of Maryland, Baltimore | 40 | 2025-08-07 | 2026-09-10 |
| CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter, 3 blood tests - Cocaine Use Disorder | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 20 | 2025-03-04 | 2026-01-15 |
| A Study to Investigate the Interaction Between TMP-301 and Cocaine. TMP-301, Placebo - Cocaine Use Disorder | Phase 1 | Completed | Tempero Bio, Inc. | 18 | 2025-01-04 | 2025-05-18 |
| Cocaine Cue-reactivity Incubation Study Cognitive Reappraisal, Control cue-reactivity task - Cocaine Use Disorder | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 252 | 2024-12-15 | 2025-07-29 |
| Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder TMS to dmPFC, TMS to dlPFC, Sham iTBS - Cocaine Use Disorder | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 75 | 2024-11-08 | 2025-05-08 |
| SXC-2023 Cocaine Interaction Study SXC-2023, SXC-2023 Placebo - Cocaine Use Disorder | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 19 | 2024-10-08 | 2026-04-24 |
| Role of Pavlovian Mechanisms for Control Over Substance Use fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm - Alcohol Use Disorder (AUD), Alcoholism | Recruiting | Technische Universität Dresden | 200 | 2024-08-05 | 2024-11-22 | |
| Exenatide For Reducing the Reinforcing Effects of Cocaine Exenatide, Placebo - Cocaine Use Disorder | Phase 1 | Withdrawn | Christopher D. Verrico | 2024-08-01 | 2026-03-13 |
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Cocaine-Related Disorders (16) · Substance-Related Disorders (14) · Opioid-Related Disorders (13) · Alcoholism (5) · Behavior, Addictive (3) · Anxiety Disorders (1) · Chemically-Induced Disorders (1) · Cognitive Dysfunction (1) · Heroin Dependence (1) · Impulsive Behavior (1) · Lymphoma, Follicular (1) · Marijuana Abuse (1) · Obesity (1) · Overweight (1) · Parasomnias (1)
Mental Disorders (39) · Chemically-Induced Disorders (34) · Substance-Related Disorders (21) · Narcotic-Related Disorders (13) · Alcohol-Related Disorders (5) · Behavior (5) · Compulsive Behavior (3) · Impulsive Behavior (3) · Pathological Conditions, Signs and Symptoms (2) · Body Weight (1) · Cognition Disorders (1) · Disease Attributes (1) · Hemic and Lymphatic Diseases (1) · Immune System Diseases (1) · Immunoproliferative Disorders (1)
Cocaine (10) · Therapeutics (6) · Methylphenidate (3) · Starch (3) · Transcranial Magnetic Stimulation (3) · BaseLine dental cement (2) · Cognitive Behavioral Therapy (2) · Exenatide (2) · Metyrapone (2) · Oxazepam (2) · Oxytocin (2) · Pioglitazone (2) · Sodium Chloride (2) · cariprazine (2) · lorcaserin (2)
The University of Texas Health Science Center, Houston (7) · William Stoops (7) · Embera NeuroTherapeutics, Inc. (4) · Yale University (4) · Icahn School of Medicine at Mount Sinai (3) · New York State Psychiatric Institute (3) · Rajesh Narendran (3) · University of Kentucky (3) · Virginia Commonwealth University (3) · Assistance Publique - Hôpitaux de Paris (2) · Friends Research Institute, Inc. (2) · Medical University of South Carolina (2) · National Institute on Drug Abuse (NIDA) (2) · Soterix Medical (2) · Tempero Bio, Inc. (2)
United States (71) · France (4) · Italy (2) · Switzerland (2) · Brazil (1) · Germany (1) · Martinique (1) · Netherlands (1) · Spain (1) · United Kingdom (1)
Debra Kelsh, MD (3) · Abhishek Datta, PhD (2) · Heather Webber, PhD (2) · Joy M Schmitz, PhD (2) · Luba Yammine, PhD (2) · Madhukar Trivedi, MD (2) · Rajesh Narendran (2) · William W Stoops, Ph.D. (2) · Aimee L McRae-Clark, PharmD (1) · Anna Rose Childress, PhD (1) · Ariel Zucher, PhD (1) · Ariel Zucker, PhD (1) · Birgit Kleim, Prof. Dr. (1) · Boris B. Quednow, Prof. Dr. (1)
PMID 31736689, PMID 32252720, PMID 33819055, PMID 34265007, PMID 34784373, PMID 36122968, PMID 36937712, PMID 37579116, PMID 38006674, PMID 38678216, PMID 38761123, PMID 38937824, PMID 39504756, PMID 40336040, PMID 40360074, PMID 40673228, PMID 40983318, PMID 40999531, PMID 41343351, PMID 42161545
R01DA026472 (3), U01DA038879 (3), P50DA009241 (2), U54DA038999 (2), K01DA058765 (1), P50DA009262 (1), R01DA030932 (1), R01DA032254 (1), R01DA035846 (1), R01DA036553 (1), R01DA037942 (1), R01DA043938 (1), R01DA045023 (1), R01DA048026 (1), R01DA048617 (1)