19 completed, 6 recruiting, 3 unknown, 1 enrolling by invitation. 30 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 30 | Completed 19, Recruiting 6, Unknown 3, Enrolling by invitation 1, Terminated 1 |
Follow Cocaine Use Disorder: new trials by email Literature Review of Cocaine Use Disorder trials Research Report on Cocaine Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder High Definition Transcranial Direct Current Stimulation - Cocaine Use Disorder | Not applicable | Recruiting | Virginia Commonwealth University | 36 | 2026-10-01 | 2026-09-28 |
| rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder Active H7-coil repetitive transcranial magnetic stimulation (rTMS), Sham H7-coil repetitive transcranial magnetic stimulation (rTMS) - Cocaine Use, Cocaine Dependence | Not applicable | Recruiting | New York State Psychiatric Institute | 30 | 2026-08-14 | 2026-10-22 |
| LDART for Stimulant Use Disorder LDART, Psychoeducational booklet - Stimulant Use Disorder, Cocaine Use Disorder | Not applicable | Enrolling by invitation | Yale University | 80 | 2026-04-29 | 2026-05-01 |
| Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 240 | 2026-02-25 | 2026-10-13 |
| CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter, 3 blood tests - Cocaine Use Disorder | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 20 | 2025-03-04 | 2026-01-15 |
| Cocaine Cue-reactivity Incubation Study Cognitive Reappraisal, Control cue-reactivity task - Cocaine Use Disorder | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 252 | 2024-12-15 | 2025-07-29 |
| Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder TMS to dmPFC, TMS to dlPFC, Sham iTBS - Cocaine Use Disorder | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 75 | 2024-11-08 | 2025-05-08 |
| Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories Imagery, Minocycline, Placebo - Post-traumatic Stress Disorder, Cocaine Use Disorder | Not applicable | Completed | Psychiatric University Hospital, Zurich | 138 | 2023-05-10 | 2026-03-06 |
| Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder Virtual Reality Cue Exposure (VRCE) Therapy for Cocaine Craving - 2 weeks, Memory Focused Cognitive Therapy (MFCT) - 1 week, Pictures-based Cue Exposure (PCE) Therapy for Cocaine Craving - 3 weeks - Cocaine Use Disorder | Not applicable | Unknown | Thomas Lehoux | 54 | 2023-05-01 | 2024-06-10 |
| Contingency Management for Drug Use: Does Age Matter? DynamiCare app (app-based contingency management), Sham control - Opioid Use Disorder, Methamphetamine Abuse | Not applicable | Completed | Wake Forest University Health Sciences | 62 | 2023-05-01 | 2026-08-18 |
| Low-Intensity Focused Ultrasound for Cocaine Use Disorder Low-Intensity Focused Ultrasound, Sham LIFU device - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Completed | University of Virginia | 25 | 2023-03-24 | 2026-05-28 |
| Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot Study) iTBS to dmPFC, Sham iTBS - Cocaine Use Disorder | Not applicable | Completed | The University of Texas Health Science Center, Houston | 6 | 2023-02-23 | 2024-01-31 |
| Temporal Window and Episodic Future Thinking in CUD Episodic Future Thinking (EFT), Control Episodic Thinking - Cocaine Use Disorder | Not applicable | Completed | Virginia Polytechnic Institute and State University | 141 | 2022-11-30 | 2025-12-02 |
| rTMS for Stimulant Use Disorders rTMS, Sham (Placebo) - Cocaine Use Disorder, Methamphetamine Abuse | Not applicable | Completed | Medical University of South Carolina | 129 | 2022-02-04 | 2025-07-03 |
| Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives App-Based Contingency Management, Sham Control - Opioid-use Disorder, Cocaine Use Disorder | Not applicable | Completed | Wake Forest University Health Sciences | 206 | 2021-09-15 | 2026-09-29 |
| Improvement of Cocaine Use Disorder Treatment Through Cognitive Behavioral Therapy Web-based Treatment (CBT4CBT) CBT4CBT - Cocaine Use Disorder | Not applicable | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 70 | 2021-04-12 | 2022-06-02 |
| Virtual Reality Exposure and Respiratory Relaxation-Based Coping With Cocaine Craving in Cocaine Users Virtual Reality Exposure to Neutral Cues, Respiratory Relaxation, Virtual Reality Exposure to Cocaine-Related Cues - Virtual Reality Exposure Therapy, Cocaine Use Disorder | Not applicable | Completed | Laboratoire de Psychologie des Cognitions | 11 | 2021-03-31 | 2022-09-27 |
| Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project Prize-Based Contingency Management, Treatment As Usual Outpatient Substance Use Treatment - Cocaine Use Disorder | Not applicable | Completed | VA Office of Research and Development | 63 | 2019-11-13 | 2025-09-30 |
| The Effect of Self-Forgiveness on Self-Stigma in Addiction. Six Step Model of Self-Forgiveness, Treatment as Usual (TAU) - Substance Use Disorders, Opiate Dependence | Not applicable | Completed | University of Pittsburgh | 130 | 2019-08-01 | 2021-09-05 |
| TDCS for Cocaine Addiction Craving Soterix Medical mini-CT tDCS stimulator - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Completed | Soterix Medical | 25 | 2019-02-01 | 2024-11-18 |
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Cocaine-Related Disorders (10) · Substance-Related Disorders (9) · Opioid-Related Disorders (6) · Alcoholism (2) · Behavior, Addictive (1) · Chemically-Induced Disorders (1) · Cognitive Dysfunction (1) · Heroin Dependence (1) · Lymphoma, Follicular (1) · Marijuana Abuse (1) · Stress Disorders, Post-Traumatic (1) · cyclopia sequence (1)
Mental Disorders (18) · Chemically-Induced Disorders (15) · Substance-Related Disorders (7) · Narcotic-Related Disorders (6) · Alcohol-Related Disorders (2) · Behavior (1) · Cognition Disorders (1) · Compulsive Behavior (1) · Hemic and Lymphatic Diseases (1) · Immune System Diseases (1) · Immunoproliferative Disorders (1) · Impulsive Behavior (1) · Lymphatic Diseases (1) · Lymphoma (1) · Lymphoma, Non-Hodgkin (1)
Therapeutics (4) · Transcranial Magnetic Stimulation (2) · Behavior Observation Techniques (1) · Minocycline (1) · Standard of Care (1)
Icahn School of Medicine at Mount Sinai (2) · New York State Psychiatric Institute (2) · The University of Texas Health Science Center, Houston (2) · Wake Forest University Health Sciences (2) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Ospedaliero-Universitaria Careggi (1) · Friends Research Institute, Inc. (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Hunter Holmes Mcguire Veteran Affairs Medical Center (1) · King's College London (1) · Laboratoire de Psychologie des Cognitions (1) · Medical University of South Carolina (1) · National Institute on Drug Abuse (NIDA) (1) · Psychiatric University Hospital, Zurich (1) · Soterix Medical (1)
United States (23) · France (2) · Italy (1) · Martinique (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Heather Webber, PhD (2) · Abhishek Datta, PhD (1) · Ariel Zucher, PhD (1) · Ariel Zucker, PhD (1) · Birgit Kleim, Prof. Dr. (1) · Boris B. Quednow, Prof. Dr. (1) · Craig R. Rush, Ph.D. (1) · Holly P Branthoover, EdD. (1) · James Bjork (1) · James M Bjork, PhD (1) · Jan Gryczynski, PhD (1) · John Mariani, MD (1) · John Marsden (1)
PMID 31736689, PMID 33819055, PMID 34784373, PMID 36122968, PMID 36937712, PMID 38006674, PMID 38678216, PMID 38937824, PMID 39504756, PMID 40336040, PMID 40983318, PMID 41343351
K01DA058765 (1), P50DA009241 (1), R01DA035846 (1), R01DA037942 (1), R01DA043938 (1), R01DA058039 (1), R01DA060914 (1), R34DA038869 (1), UG1DA013727 (1), UG3DA056138-01A1 (1), UG3DA063211 (1)