33 completed, 4 terminated, 3 unknown, 2 withdrawn. 15 Phase 1, 13 Not applicable, 7 Phase 2, 2 Early Phase 1, 1 Phase 3.
Follow Cocaine Abuse: new trials by email Literature Review of Cocaine Abuse trials Research Report on Cocaine Abuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War) AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central) - Asperger's Disorder, Asperger Disorder | Not applicable | Not yet recruiting | Veterans Recovery Network Inc. | 1000000 | 2026-10-01 | 2026-10-29 |
| Comparing Efficacy & Safety Of TNX-1300 To Placebo With UC For Treatment Of Acute Cocaine Intoxication In ED Subjects (CATALYST) TNX-1300 (Injection), Placebo (Injection) - Cocaine Use, Cocaine Intoxication | Phase 2 | Terminated | Tonix Pharmaceuticals, Inc. | 3 | 2024-08-16 | 2025-06-24 |
| Dopamine Rhythms in Health and Addiction Brain Dopamine Reactivity, Brain Dopamine Receptor - Cocaine Abuse | Early Phase 1 | Withdrawn | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 2024-04-23 | 2024-04-24 | |
| Clinical and Atherosclerotic Characteristics of Patients With ACS Associated With Cocaine Use Myocardial Infarction, Acute Coronary Syndrome | Unknown | Hospital El Cruce | 400 | 2023-11-17 | 2024-01-05 | |
| Effect of rTMS on Neurotrophines Levels in CUD rTMS - Cocaine Use, Cocaine Dependence | Not applicable | Unknown | ITAB - Institute for Advanced Biomedical Technologies | 60 | 2023-04-30 | 2023-04-21 |
| Low-Intensity Focused Ultrasound for Cocaine Use Disorder Low-Intensity Focused Ultrasound, Sham LIFU device - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Completed | University of Virginia | 25 | 2023-03-24 | 2026-05-28 |
| rTMS for Stimulant Use Disorders rTMS, Sham (Placebo) - Cocaine Use Disorder, Methamphetamine Abuse | Not applicable | Completed | Medical University of South Carolina | 129 | 2022-02-04 | 2025-07-03 |
| The Effect of Self-Forgiveness on Self-Stigma in Addiction. Six Step Model of Self-Forgiveness, Treatment as Usual (TAU) - Substance Use Disorders, Opiate Dependence | Not applicable | Completed | University of Pittsburgh | 130 | 2019-08-01 | 2021-09-05 |
| Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study Clavulanic acid, Intravenous cocaine, Placebo - Cocaine Dependence, Cocaine Addiction | Phase 1 | Completed | Temple University | 10 | 2016-10-24 | 2023-11-03 |
| Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin Lorcaserin, Placebo, Cocaine Infusion - Cocaine Abuse | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 20 | 2015-05-01 | 2017-01-11 |
| n-Acetylcysteine and Cocaine Cocaine, n-Acetylcysteine, Placebo - Cocaine Abuse, Cocaine Dependence | Early Phase 1 | Completed | University of Kentucky | 15 | 2014-05-01 | 2017-01-04 |
| Prize Contingency Management for Cocaine-Dependent Methadone Patients prize contingency management - Cocaine Abuse | Not applicable | Completed | UConn Health | 280 | 2011-11-01 | 2019-03-13 |
| Pramipexole as a Treatment for Cocaine Dependence Pramipexole, Placebo - Cocaine Addiction, Cocaine Abuse | Phase 1 | Completed | Baylor College of Medicine | 10 | 2011-10-01 | 2014-07-22 |
| Exercise as a Behavioral Treatment for Cocaine Dependence Sitting, Running, Walking - Cocaine Dependence, Cocaine Addiction | Not applicable | Completed | Baylor College of Medicine | 24 | 2011-09-01 | 2015-01-27 |
| ALK33BUP-101: Safety and Pharmacodynamic Effects of ALKS 33-BUP Administered Alone and When Co-administered With Cocaine ALKS 33-BUP, ALKS 33, Placebo - Cocaine Abuse | Phase 1 | Completed | Alkermes, Inc. | 33 | 2011-08-01 | 2012-03-09 |
| A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence Placebo, Cabergoline - Cocaine Dependence, Cocaine Abuse | Phase 1 | Completed | Baylor College of Medicine | 11 | 2011-07-01 | 2012-07-27 |
| Progesterone for Postpartum Cocaine Relapse Progesterone, Placebo - Cocaine Abuse, Cocaine Dependence | Not applicable | Completed | Yale University | 50 | 2011-02-01 | 2017-03-28 |
| Modafinil - Escitalopram Study for Cocaine Dependence Modafinil and Escitalopram, Placebo, Modafinil - Cocaine Dependence, Cocaine Abuse | Phase 1 | Completed | Baylor College of Medicine | 68 | 2010-08-01 | 2012-05-18 |
| Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE) L-dopa / carbidopa / entacapone (LCE) - Cocaine Abuse | Phase 1 | Completed | New York State Psychiatric Institute | 15 | 2010-08-01 | 2018-05-21 |
| Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence Citicoline, Placebo - Mania, Hypomania | Phase 3 | Completed | University of Texas Southwestern Medical Center | 44 | 2010-07-01 | 2014-08-11 |
Showing 20 of 43. Sign in to see all of them.
Cocaine-Related Disorders (43) · Substance-Related Disorders (13) · Opioid-Related Disorders (6) · Behavior, Addictive (5) · Alcoholism (4) · Heroin Dependence (3) · Marijuana Abuse (3) · Smoking (2) · Acute Coronary Syndrome (1) · Asperger Syndrome (1) · Attention Deficit Disorder with Hyperactivity (1) · Autistic Disorder (1) · Chemically-Induced Disorders (1) · Coitus (1) · Compulsive Sexual Behavior Disorder (1)
Chemically-Induced Disorders (42) · Mental Disorders (42) · Substance-Related Disorders (30) · Behavior (7) · Narcotic-Related Disorders (6) · Compulsive Behavior (5) · Impulsive Behavior (5) · Alcohol-Related Disorders (4) · Pathological Conditions, Signs and Symptoms (4) · Pathologic Processes (3) · Disease Attributes (2) · Attention Deficit and Disruptive Behavior Disorders (1) · Autism Spectrum Disorder (1) · Cardiovascular Diseases (1) · Child Development Disorders, Pervasive (1)
Sugars (7) · Modafinil (4) · Levodopa (3) · Carbidopa (2) · Cocaine (2) · Cognitive Behavioral Therapy (2) · Naltrexone (2) · Progesterone (2) · Therapeutics (2) · carbidopa, levodopa drug combination (2) · Acetylcysteine (1) · Aripiprazole (1) · Buprenorphine (1) · Cabergoline (1) · Citalopram (1)
Yale University (7) · Baylor College of Medicine (6) · National Institute on Drug Abuse (NIDA) (5) · The University of Texas Health Science Center, Houston (5) · New York State Psychiatric Institute (2) · Alkermes, Inc. (1) · Hospital El Cruce (1) · ITAB - Institute for Advanced Biomedical Technologies (1) · Johns Hopkins University (1) · Medical University of South Carolina (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · Seattle Institute for Biomedical and Clinical Research (1) · Temple University (1) · Tonix Pharmaceuticals, Inc. (1) · Treatment Research Institute (1)
United States (40) · Argentina (1) · Italy (1)
John Grabowski, PhD (2) · Joy M Schmitz, PhD (2) · Richard De La Garza, II, PhD (2) · Adam Bisaga, M.D. (1) · Andre M Tapp, MD (1) · Angela L Stotts, PhD (1) · Bernard L. Silverman, MD (1) · Deanna L Kelly, Pharm.D., BCPP (1) · Debra Kelsh, Ph.D. (1) · E. Sherwood Brown, PH.D., M.D. (1) · F. Gerard Moeller, M.D. (1) · Frederick G Moeller, MD (1) · Frederick G. Moeller, PhD (1) · Gene-Jack Wang, M.D. (1) · Gregory Sullivan, MD (1)
PMID 22775772, PMID 42423707, PMID 11484693, PMID 16887281, PMID 17084789, PMID 17523584, PMID 17624688, PMID 17907858, PMID 17931826, PMID 18056026, PMID 18068905, PMID 21190403, PMID 21690608, PMID 22319592, PMID 22695473, PMID 22795046, PMID 24424425, PMID 24447885, PMID 24577287, PMID 25124257, PMID 25982006, PMID 26239766, PMID 27658192, PMID 28270105, PMID 29535062, PMID 29622433, PMID 30240978, PMID 30700023, PMID 32515821, PMID 34453835, PMID 40336040
P50DA009262 (5), P50DA018197 (3), 1RC1DA028387 (1), P50DA009236 (1), P50DA009241 (1), R01DA012952 (1), R01DA013444 (1), R01DA014573 (1), R01DA017444 (1), R01DA019078 (1), R01DA019135 (1), R01DA023624 (1), R01DA031000 (1), R21DA029914 (1), R21DA030722 (1)