9 recruiting, 8 not yet recruiting, 5 completed, 1 active not recruiting. 14 Not applicable, 2 Phase 3, 2 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 14 | Recruiting 5, Completed 4, Not yet recruiting 4, Active not recruiting 1 |
| Phase 3 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 4 | 2 | Not yet recruiting 2 |
| Phase 1 | 1 | Completed 1 |
Follow Chronic Migraine Headache: new trials by email Literature Review of Chronic Migraine Headache trials Research Report on Chronic Migraine Headache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine Neurostimulator - Resistant Migraine, Chronic Migraine Headache | Not applicable | Recruiting | Salvia BioElectronics | 150 | 2026-12-01 | 2026-08-28 |
| Laser Acupuncture for Chronic Migraine: Clinical Response, Traditional Chinese Medicine Syndrome Patterns, and Brain Function 810 nm laser acupuncture, Sham Laser Acupuncture - Chronic Migraine Headache | Not applicable | Not yet recruiting | Taichung Veterans General Hospital | 300 | 2026-11-01 | 2026-10-23 |
| Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine Low-Intensity Focused Ultrasound Stimulation, Sham Low-Intensity Focused Ultrasound Stimulation - Chronic Migraine Headache | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 36 | 2026-10-08 | 2026-10-05 |
| Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine Ultrasound-guided pulsed radiofrequency (PRF), OnabotulinumtoxinA - Chronic Migraine Headache | Phase 4 | Not yet recruiting | Assiut University | 70 | 2026-10-01 | 2026-09-22 |
| Psychological Support for Chronic Migraine Patients Treated With Anti-CGRP (Anti-Calcitonin Gene-Related Peptide ) Monoclonal Antibodies Chronic Migraine Headache, Psychologic Adaptation | Not yet recruiting | Central Hospital, Nancy, France | 30 | 2026-10-01 | 2026-10-16 | |
| Efficacy of Ultrasound-Guided Combined Greater Occipital Nerve Block and Greater Auricular Nerve Block Versus Greater Occipital Nerve Block Alone in the Management of Chronic Migraine greater occipital nerve block, Greater Auricular Nerve Block - Chronic Migraine Headache | Phase 4 | Not yet recruiting | Assiut University | 80 | 2026-09-01 | 2026-08-13 |
| EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine Middle Meningeal Artery Embolization - Migraine Disorders, Chronic Migraine Headache | Recruiting | Cortex Neurovascular | 50 | 2026-09-01 | 2026-09-23 | |
| EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) OF PRIMARY MOTOR CORTEX ON HEADACHE FREQUENCY IN PATIENTS WITH CHRONIC MIGRAINE Transcranial Direct Current stimulation - Chronic Migraine Headache, Chronic Migraine, Headache | Phase 3 | Not yet recruiting | Dr. Ram Manohar Lohia Hospital | 32 | 2026-08-01 | 2026-08-04 |
| The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine Chronic Migraine Headache | Recruiting | Istituto per la Ricerca e l'Innovazione Biomedica | 200 | 2026-07-01 | 2026-06-01 | |
| Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine embolization of middle meningeal arteries - Migraine, Chronic Migraine Headache | Not applicable | Recruiting | Johns Hopkins University | 13 | 2026-04-24 | 2026-09-03 |
| Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine OnabotulinumtoxinA, Greater Occipital Nerve Block (GONB) - Chronic Migraine Headache, OnabotulinumtoxinA | Not applicable | Not yet recruiting | Beni-Suef University | 90 | 2026-04-01 | 2026-04-17 |
| TCDS for the Treatment of Chronic Migraine Transcranial direct current stimulation (Nettle device) 2mA stimulation for 20 minutes per day - Chronic Migraine Headache, Transcranial Direct Current Stimulation | Not applicable | Not yet recruiting | University College, London | 20 | 2026-02-01 | 2025-12-04 |
| Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Chronic Migraine MTrPs Injection, Greater occipital nerve block group - Myofascial Trigger Points, Chronic Migraine Headache | Not applicable | Recruiting | Beijing Tiantan Hospital | 1036 | 2025-12-01 | 2026-01-16 |
| The Nordic Chronic Migraine Trial of CGRP Monoclonal Antibody and Onabotulinumtoxin A Dual Therapy Compared to CGRP mAbs Monotherapy CGRP mAbs and onabotulinumtoxin A, CGRP mAbs and placebo - Migraine, Chronic Migraine Headache | Phase 3 | Recruiting | Oslo University Hospital | 450 | 2025-06-06 | 2025-06-27 |
| The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block - Chronic Migraine Headache, Radiofrequency Ablation | Not applicable | Active not recruiting | Aydin Adnan Menderes University | 100 | 2025-05-29 | 2026-02-09 |
| Efficacy of Traditional Integrated Islamic Psychotherapy and Cognitive Behavioural Therapy for Migraine: A Randomized Controlled Trial Cognitive Behavioral Therapy (CBT), Traditional Integrated Islamic Psychotherapy (TIIP), Medication Group - Chronic Migraine Headache | Not applicable | Completed | GIFT University | 45 | 2025-03-10 | 2026-09-03 |
| Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache Bupivacaine, Normal Saline (0.9% NaCl), Greater occipital nerve blockade - Chronic Migraine Headache, Chronic Tension-type Headache | Not applicable | Completed | Saglik Bilimleri Universitesi | 290 | 2025-01-01 | 2026-03-27 |
| CHROnic Migraine Embolization liquid embolic agent SQUID 12, liquid embolic agent SQUID 18 - Chronic Migraine Headache | Not applicable | Recruiting | Vedanta University Clinic | 30 | 2024-10-17 | 2026-09-11 |
| Relieving Chronic Pain: Psychosomatic Mechanisms and Psychological Interventions in Fibromyalgia and Chronic Headache Dynamic interpersonal therapy (DIT), technique of expressive writing (TSE), Treatment as Usual (TAU) - Fibromyalgia (FM), Chronic Migraine Headache | Not applicable | Recruiting | University of Roma La Sapienza | 400 | 2024-09-17 | 2024-10-22 |
| Clinical Exploration of NEUROMARK System in Participants With Chronic Migraine NEUROMARK System - Chronic Migraine Headache | Not applicable | Completed | Neurent Medical | 24 | 2024-09-06 | 2026-09-16 |
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Migraine Disorders (7) · Headache (4) · Headache Disorders (2) · Chronic Pain (1) · Cluster Headache (1) · Fibromyalgia (1) · Migraine with Aura (1) · Migraine without Aura (1)
Nervous System Diseases (10) · Brain Diseases (9) · Central Nervous System Diseases (9) · Headache Disorders (7) · Headache Disorders, Primary (7) · Neurologic Manifestations (5) · Pain (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Muscular Diseases (1) · Musculoskeletal Diseases (1) · Neuromuscular Diseases (1) · Rheumatic Diseases (1) · Trigeminal Autonomic Cephalalgias (1)
Botulinum Toxins, Type A (3) · Transcranial Direct Current Stimulation (2) · Bupivacaine (1) · Cognitive Behavioral Therapy (1) · Hematologic Tests (1) · Implantable Neurostimulators (1) · Saline Solution (1) · Sodium Chloride (1) · Therapeutics (1)
Assiut University (2) · Ankara City Hospital Bilkent (1) · Aydin Adnan Menderes University (1) · Beijing Tiantan Hospital (1) · Beni-Suef University (1) · Central Hospital, Nancy, France (1) · Chinese PLA General Hospital (1) · Cortex Neurovascular (1) · Dr. Ram Manohar Lohia Hospital (1) · GIFT University (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Istituto per la Ricerca e l'Innovazione Biomedica (1) · Johns Hopkins University (1) · MedtronicNeuro (1) · Neurent Medical (1)
United States (5) · Turkey (Türkiye) (3) · China (2) · Italy (2) · Canada (1) · Egypt (1) · France (1) · India (1) · Kyrgyzstan (1) · Norway (1) · Pakistan (1) · Spain (1) · Taiwan (1) · United Kingdom (1)
Andrey S Petrov, MD, PhD (1) · Ashish K Duggal, DM Neurology (1) · Ather Mujitaba, pHD in Clincal Psychology (1) · Cristina Iannuccelli, Dr (1) · Federica Galli, Professor (1) · Joel Saper, M.D. (1) · Lorys Castelli, Professor (1) · Piercarlo Sarzi-Puttini, MD, Professor (1) · Risheng Xu, MD, PhD (1) · Sara Bottiroli, Professor (1)
PMID 17504651, PMID 17682008, PMID 19614709, PMID 20838644, PMID 20861241, PMID 30612462, PMID 37901421, PMID 39198866, PMID 39801092