135 completed, 47 unknown, 38 recruiting, 11 active not recruiting. 185 Not applicable, 18 Phase 2, 7 Phase 1, 5 Phase 3, 3 Phase 4.
Follow Chronic Low-back Pain: new trials by email Literature Review of Chronic Low-back Pain trials Research Report on Chronic Low-back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multichannel Neuromuscular Electrical Stimulation With Core Exercise for Chronic Low Back Pain Core exercise program, StimaWELL 120MTRS - lumbar strengthening program, StimaWELL 120MTRS - muscle relaxation program - Chronic Low-back Pain | Not applicable | Recruiting | Uskudar University | 45 | 2026-08-14 | 2026-08-18 |
| Algorithm-informed Decision-making to Advance Pain Treatment Algorithmically informed randomization (taking into account phenotypes), Physical Therapy (PT) and Exercise, Cognitive-Behavioral Therapy for Pain (PRISM-CBT) - Chronic Low-back Pain | Not applicable | Recruiting | University of Michigan | 500 | 2026-07-23 | 2026-09-15 |
| Effectiveness of Thread-Embedding Acupuncture at EX-B2 on the Oswestry Disability Index and Finger-to-Floor Distance in Chronic Low Back Pain Thread Embedding Acupuncture, Sham Thread Embedding Acupuncture - Chronic Low-back Pain | Not applicable | Completed | Universitas Indonesia | 32 | 2026-03-13 | 2026-07-07 |
| Effect of Connective Tissue Massage in Low Back Pain Connective tissue massage, Sham connective tissue massage - Chronic Low-back Pain | Not applicable | Not yet recruiting | Okan University | 40 | 2026-02-09 | 2026-03-10 |
| Palmitoylethanolamide Modulates Central Sensitisation and Neuroinflammation in Chronic Low Back Pain Palmitoylethanolamide - Chronic Low-back Pain | Not applicable | Recruiting | Beni-Suef University | 106 | 2026-01-01 | 2026-08-19 |
| Effects of Dynamic Neuromuscular Stabilization on Pain, Posture, and Quality of Life in Chronic Low Back Pain DNS Group, Control Group - Chronic Low-back Pain | Not applicable | Completed | Uskudar University | 20 | 2025-12-03 | 2026-05-05 |
| Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control Boston Scientific WaveWriter Alpha™ SCS Systems - Chronic Pain, Intractable Pain | Not applicable | Recruiting | Boston Scientific Corporation | 70 | 2025-11-07 | 2026-10-13 |
| Movement Performance in Persons With Chronic Back Pain SMT, ET, OLP - Chronic Low-back Pain, Back Disorder | Not applicable | Recruiting | Karolinska Institutet | 40 | 2025-09-01 | 2025-07-14 |
| Modulation Effect of tACS on Chronic Low Back Pain Real tACS, Sham tACS - Chronic Low-back Pain | Phase 2 | Recruiting | Massachusetts General Hospital | 80 | 2025-08-25 | 2026-03-16 |
| AuriculoTherapy NeuroImaging Cryo-auriculotherapy, Sham auriculotherapy, Experimental auricular stimulation - Low Back Pain, Chronic Low-back Pain | Not applicable | Recruiting | Keith M Vogt | 60 | 2025-07-30 | 2026-02-18 |
| Clinician Satisfaction With the VERABAND™ VERABAND information - Chronic Low-back Pain | Not applicable | Recruiting | University of Michigan | 360 | 2025-06-09 | 2026-06-03 |
| Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain iovera system, Radiofrequency ablation alone - Chronic Low-back Pain | Not applicable | Active not recruiting | University of Kansas Medical Center | 30 | 2025-05-13 | 2026-10-08 |
| Weight Reduction in CLBP Pain Neuroscience Education, Cognition-targeted exercise therapy, Behavioral weight reduction program - Chronic Low-back Pain, Overweight or Obesity | Not applicable | Recruiting | Vrije Universiteit Brussel | 84 | 2025-05-01 | 2026-08-20 |
| Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain Intracept™ Intraosseous Nerve Ablation - Chronic Low-back Pain, Vertebrogenic Pain Syndrome | Recruiting | Boston Scientific Corporation | 1500 | 2025-03-26 | 2026-10-09 | |
| Effects Of Inversion Table Therapy Vs MT On Pain And Lumbar Flexibility In Patients With Chronic Low Back Pain Inversion Table, Mulligan flexion biased exercises - Chronic Low-back Pain | Not applicable | Active not recruiting | Superior University | 54 | 2025-03-17 | 2025-07-09 |
| HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain Open-label Placebo, Standard Rationale, Mindfulness - Chronic Low-back Pain, Chronic Pain | Not applicable | Completed | Rhode Island Hospital | 327 | 2025-03-10 | 2026-07-23 |
| Evaluation of the Benefit and Safety of Localized Tissue Hydration in the Management of Chronic Low Back Pain Sodium Chloride injection - Chronic Low-back Pain | Phase 2 | Completed | GCS Ramsay Santé pour l'Enseignement et la Recherche | 30 | 2025-02-28 | 2026-06-15 |
| Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity gp-multitool.de - Asthma Bronchiale, Breast Neoplasms | Not applicable | Active not recruiting | Universitätsklinikum Hamburg-Eppendorf | 659 | 2025-02-26 | 2026-05-29 |
| Comparative Effects of Motor Control and Isolated Strengthening Lumbar Exercises on Functional Outcomes in Patients with Chronic Low Back Pain Motor control exercises, Isolated strengthening lumbar exercises - Chronic Low-back Pain | Not applicable | Not yet recruiting | University of Faisalabad | 35 | 2025-02-01 | 2025-02-19 |
| Improving Health for Patients With Chronic Low Back Pain in Rural Communities Through Telerehabilitation Standardized Education, Telerehabilitation - Chronic Low-back Pain | Not applicable | Recruiting | Johns Hopkins University | 434 | 2025-01-27 | 2026-07-22 |
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Low Back Pain (60) · Chronic Pain (30) · Pain (21) · Back Pain (17) · Motor Activity (12) · Intervertebral Disc Degeneration (11) · Bronchiolitis Obliterans Syndrome (6) · Depression (5) · Fibromyalgia (5) · Intervertebral Disc Displacement (5) · Agnosia (4) · Anxiety Disorders (3) · Kinesiophobia (3) · Obesity (3) · Pain, Intractable (3)
Pathological Conditions, Signs and Symptoms (113) · Signs and Symptoms (110) · Neurologic Manifestations (108) · Pain (85) · Back Pain (53) · Musculoskeletal Diseases (23) · Behavior (21) · Nervous System Diseases (18) · Bone Diseases (15) · Spinal Diseases (14) · Mental Disorders (12) · Respiratory Tract Diseases (9) · Immune System Diseases (8) · Rheumatic Diseases (8) · Joint Diseases (7)
Exercise (11) · Physical Therapy Modalities (9) · Control Groups (7) · Therapeutics (5) · Musculoskeletal Manipulations (4) · Acceptance and Commitment Therapy (3) · Duloxetine Hydrochloride (3) · Exercise Therapy (3) · Movement (3) · Radiofrequency Ablation (3) · Telerehabilitation (3) · Acupuncture Therapy (2) · Dry Needling (2) · High-Intensity Interval Training (2) · Manipulation, Chiropractic (2)
Riphah International University (6) · Eli Lilly and Company (5) · Cairo University (4) · Hacettepe University (4) · Spinal Stabilization Technologies (4) · University of Kansas Medical Center (4) · Vrije Universiteit Brussel (4) · Hasan Kalyoncu University (3) · Hasselt University (3) · Johns Hopkins University (3) · Kutahya Health Sciences University (3) · Massachusetts General Hospital (3) · The Hong Kong Polytechnic University (3) · Universidad de Almeria (3) · University of California, San Francisco (3)
United States (68) · Turkey (Türkiye) (29) · Spain (18) · France (16) · Pakistan (15) · Belgium (10) · Canada (10) · Egypt (10) · Germany (8) · Brazil (6) · Puerto Rico (5) · South Korea (5) · Denmark (4) · Switzerland (4) · United Kingdom (4)
Michael Hess, MD (4) · Daniel Clauw, MD (3) · Afton Hassett, PsyD (2) · Amal Fawzy, Ph.d (2) · Annick Timmermans (2) · Carrie E Brintz, PhD (2) · Jeff Golan, MD (2) · Wolf E Mehling, MD (2) · Abdullah Okur (1) · Adam Gonzalez, PhD (1)
PMID 12952518, PMID 15976161, PMID 16137981, PMID 16449365, PMID 18806553, PMID 19197573, PMID 21083513, PMID 21947373, PMID 22231424, PMID 22336956, PMID 23246998, PMID 23427384, PMID 23891481, PMID 23894731, PMID 24707200, PMID 24994051, PMID 25535198, PMID 25879522, PMID 26023217, PMID 26093806, PMID 26329399, PMID 26444559, PMID 27062464, PMID 27062965, PMID 27209166, PMID 27344193, PMID 27713336, PMID 28441294, PMID 28845185, PMID 28860855, PMID 29126136, PMID 29141611, PMID 29464338, PMID 30116793, PMID 30284083, PMID 30288088, PMID 30526011, PMID 31322903, PMID 31408011, PMID 31443625, PMID 31517832, PMID 31764164, PMID 32026838, PMID 32049888, PMID 32870936, PMID 33762244, PMID 33848704, PMID 34003285, PMID 34011351, PMID 34115979
2019 (2), K23AT011569 (2), 2018 (1), K01AT012066 (1), K23AR083171 (1), K99AG052642 (1), R00AG052642 (1), R01AG041202 (1), R01NS129059 (1), R21AT011577 (1), R33AT012317 (1), R34AT009555 (1), R34AT010921 (1), R41AT011996 (1), R44DA049630 (1)