20 unknown. 20 Phase 2, 9 Phase 1, 7 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Unknown 20 |
| Phase 1 | 9 | Unknown 9 |
| Phase 3 | 7 | Unknown 7 |
Follow Chronic Limb-Threatening Ischemia: new trials by email Literature Review of Chronic Limb-Threatening Ischemia trials Research Report on Chronic Limb-Threatening Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of AMG0001 to Improve Ulcer Healing and Perfusion in Subjects With Peripheral Ischemic Ulcers AMG0001, Placebo - Peripheral Artery Disease, Ischaemic Ulcer of Lower Leg Due to Atherosclerotic Disease | Phase 2 | Unknown | AnGes USA, Inc. | 60 | 2020-01-30 | 2021-12-22 |
| Revascularization of Stenosed Vessels Using Optimized Treatment of Rejuveinix for Reversing Endothelial Dysfunction Rejuveinix Low Dose, Rejuveinix High Dose - Critical Limb Ischemia, Peripheral Arterial Disease | Phase 1 / Phase 2 | Unknown | Reven Pharmaceuticals, Inc. | 320 | 2020-01-01 | 2018-08-09 |
| Cell Therapy in Critical Limb Ischemia allogeneic umbilical cord-derived mesenchymal stem cells, Placebo (NaCl) - Critical Limb Ischemia | Phase 2 | Unknown | CHU de Reims | 30 | 2019-09-01 | 2019-06-21 |
| Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs Allogeneic Mesenchymal Stromal Cell, Placebo - Peripheral Arterial Disease, Cardiovascular Diseases | Phase 2 / Phase 3 | Unknown | Martin Teraa, MD, PhD | 60 | 2018-12-01 | 2018-05-03 |
| Cardiovascular Clinical Project to Evaluate the Regenerative Capacity of CardioCell in Patients With No-option Critical Limb Ischemia (N-O CLI) CardioCell, Placebos - Critical Limb Ischemia | Phase 2 / Phase 3 | Unknown | John Paul II Hospital, Krakow | 50 | 2018-04-19 | 2021-04-09 |
| An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK) Ranger SL DEB - Lower Limb Ischemia, Peripheral Vascular Diseases | Phase 2 / Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 30 | 2016-11-01 | 2018-05-18 |
| Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia ADRC injection, ADRC isolation, Liposuction - Critical Limb Ischemia, Arteriosclerosis Obliterans | Phase 1 / Phase 2 | Unknown | Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation | 9 | 2016-07-01 | 2016-08-12 |
| To Evaluate the Safety and Efficacy of IM and IV Administration of Autologous ADMSCs for Treatment of CLI Autologous Stromal Vascular Fraction (SVF), Autologous Adipose Derieved MSCs, Control - Critical Limb Ischemia | Phase 1 / Phase 2 | Unknown | Kasiak Research Pvt. Ltd. | 60 | 2014-08-01 | 2014-05-23 |
| Allogeneic Mesenchymal Stem Cells for the Critical Limb Ischemia Therapy Mesenchymal stem cells, Normal saline - Critical Limb Ischemia | Phase 1 / Phase 2 | Unknown | Federal Research Clinical Center of Federal Medical & Biological Agency, Russia | 40 | 2013-10-01 | 2017-08-04 |
| VADOplex Critical Limb Ischemia Study VADOplex system - Peripheral Artery Disease, Quality of Life | Phase 2 / Phase 3 | Unknown | Asklepios Kliniken Hamburg GmbH | 38 | 2013-10-01 | 2014-01-13 |
| Phase I/II Trial of Endometrial Regenerative Cells (ERC) in Patients With Critical Limb Ischemia Administration of ERC - Peripheral Vascular Diseases | Phase 1 / Phase 2 | Unknown | Medistem Inc. | 15 | 2012-05-01 | 2012-03-20 |
| Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb Ischemia ResQ processed bone marrow sample, Ficoll conventional cell processing method - Critical Limb Ischemia, Peripheral Arterial Disease | Phase 1 / Phase 2 | Unknown | Xuanwu Hospital, Beijing | 50 | 2011-10-01 | 2011-10-12 |
| Intramuscular Mononuclear Cells and Mesenchymal Stem Cells Transplantation to Treat Chronic Critical Limb Ischemia Mononuclear and mesenchymal stem cells, Mononuclear cells - Critical Limb Ischemia | Phase 2 | Unknown | National University of Malaysia | 50 | 2011-03-01 | 2015-04-10 |
| Umbilical Cord Mesenchymal Stem Cells Injection for Diabetic Foot umbilical cord mesenchymal stem cells, Standard Therapy - Diabetic Foot, Critical Limb Ischemia | Phase 1 / Phase 2 | Unknown | Qingdao University | 50 | 2011-01-01 | 2010-10-13 |
| Safety Study of MultiGeneAngio in Patients With Chronic Critical Limb Ischemia MultiGeneAngio - Peripheral Arterial Disease, Peripheral Vascular Disease | Phase 1 / Phase 2 | Unknown | MultiGene Vascular Systems Ltd. | 28 | 2010-02-01 | 2015-03-05 |
| Distal Venous Arterialisation of Ischemic Limb distal venous arterialisation, Aspirin - Critical Limb Ischemia | Phase 2 / Phase 3 | Unknown | Clinical Centre of Serbia | 30 | 2009-09-01 | 2010-09-30 |
| A Clinical Trial on Diabetic Foot Using Peripheral Blood Derived Stem Cells for Treating Critical Limb Ischemia will receive G-CSF and peripheral blood derived mononuclear cells, G-CSF, Standard Therapy - Diabetic Foot, Critical Limb Ischemia | Phase 1 / Phase 2 | Unknown | Beike Biotech India Pvt.ltd | 36 | 2009-07-01 | 2009-06-17 |
| Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia bone marrow derived mononuclear cells, placebo - Intermittent Claudication, Peripheral Vascular Diseases | Phase 2 / Phase 3 | Unknown | Leiden University Medical Center | 108 | 2007-10-01 | 2011-07-06 |
| PTA and Drug Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia PTA with placement of paclitaxel-eluting stent, PTA - Peripheral Vascular Disease | Phase 2 / Phase 3 | Unknown | Netherlands Society for Interventional Radiology | 144 | 2007-08-01 | 2020-09-16 |
| UT-15C SR in the Treatment of Critical Limb Ischemia UT-15C SR (treprostinil diethanolamine) 1mg oral tablets - Critical Limb Ischemia | Phase 2 | Unknown | Southern Arizona Vascular Institute | 20 | 2006-11-01 | 2007-03-08 |
Peripheral Arterial Disease (8) · Peripheral Vascular Diseases (6) · Diabetic Foot (3) · Thromboangiitis Obliterans (2) · Arteriosclerosis Obliterans (1) · Cardiovascular Diseases (1) · Diabetes Complications (1) · Diabetic Angiopathies (1) · Intermittent Claudication (1) · Leg Ulcer (1) · Peripheral Arterial Occlusive Disease 1 (1) · Vascular Diseases (1)
Arterial Occlusive Diseases (20) · Arteriosclerosis (20) · Atherosclerosis (20) · Chronic Disease (20) · Disease Attributes (20) · Ischemia (20) · Pathologic Processes (20) · Pathological Conditions, Signs and Symptoms (20) · Cardiovascular Diseases (19) · Vascular Diseases (19) · Peripheral Vascular Diseases (14) · Peripheral Arterial Disease (12) · Diabetes Mellitus (4) · Endocrine System Diseases (4) · Diabetes Complications (3)
Standard of Care (2) · Aspirin (1) · Drug Therapy (1) · Granulocyte Colony-Stimulating Factor (1) · Lipectomy (1) · Saline Solution (1) · ascorbic acid, magnesium sulfate heptahydrate, cyanocobalamin, thiamine hydrochloride, riboflavin 5' phosphate, niacinamide, pyridoxine hydrochloride, and calcium D-pantothenate drug combination (1) · treprostinil (1)
AnGes USA, Inc. (1) · Asklepios Kliniken Hamburg GmbH (1) · Assistance Publique - Hôpitaux de Paris (1) · Beike Biotech India Pvt.ltd (1) · CHU de Reims (1) · Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation (1) · Clinical Centre of Serbia (1) · Federal Research Clinical Center of Federal Medical & Biological Agency, Russia (1) · John Paul II Hospital, Krakow (1) · Kasiak Research Pvt. Ltd. (1) · Leiden University Medical Center (1) · Martin Teraa, MD, PhD (1) · Medistem Inc. (1) · MultiGene Vascular Systems Ltd. (1) · National University of Malaysia (1)
Netherlands (3) · United States (3) · China (2) · France (2) · India (2) · Russia (2) · Germany (1) · Israel (1) · Malaysia (1) · Poland (1) · Serbia (1)
Andrey A Kalinin, MD, PhD (1) · Andrey A Pulin, MD, PhD (1) · Colleen Johnson, MD (1) · David G Armstrong, MD, DPM, PhD (1) · Dr. Anoop Misra, MD (1) · Dr. Arun B Bal, M.B.B.S.M.S. (1) · Dr. Ashish S Johari, M.B.B.S.M.S. (1) · Dr. Meena Kumar, M.B.B.S.M.S. (1) · Evgeny R Lysenko, MD, PhD, Prof (1) · Gert Jan de Borst, MD, PhD (1) · Hanafiah Harunarashid, MD (1) · Hans Van Overhagen, MD PhD (1) · Holger Lawall, MD (1) · Jan HN Lindeman, MD, PhD (1)
PMID 19700099, PMID 26861113, PMID 28411244, PMID 29242062, PMID 30004916, PMID 35802393, PMID 41186002