96 completed, 38 recruiting, 34 unknown, 19 terminated. 57 Phase 2, 43 Not applicable, 25 Phase 1, 18 Phase 3, 7 Phase 4.
Follow Cholangitis: new trials by email Literature Review of Cholangitis trials Research Report on Cholangitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FEAST and HOPE: Redox PSC Pilot Study N-Acetyl Cysteine (NAC), Alpha-Lipoic Acid (ALA), Nicotinamide Riboside (NR) - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 15 | 2027-01-01 | 2026-10-27 |
| Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Nemolizumab-ilto - Chronic Hepatic Pruritus, Cholestatic Liver Disease | Phase 2 | Not yet recruiting | Mayo Clinic | 15 | 2026-11-01 | 2026-09-28 |
| Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis Oral Vancomycin - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Tampere University Hospital | 140 | 2026-10-01 | 2026-09-10 |
| Rifaximin for Prevention of Recurrent Mild-to-moderate Ascending Cholangitis After Biliary-enteric Anastomosis Rifaximin combined with standard care, Standard Care (in control arm) - Cholangitis, Ascending Cholangitis | Phase 4 | Not yet recruiting | Ruijin Hospital | 60 | 2026-10-01 | 2026-10-30 |
| LEOPARD Prospective Validation Cohort 1 Standardized assessments, guided tumor biopsy and biobanking, Standardized assessments and biobanking - Decompensated Liver Cirrhosis, Primary Biliary Cholangitis | Recruiting | Assistance Publique - Hôpitaux de Paris | 630 | 2026-07-07 | 2026-07-29 | |
| EUS-Guided Gallbladder Drainage Versus Conservative Management in Patients Unfit for Surgery After a Biliary Event Without Cholecystitis. DRECON Study EUS-guided gallbladder drainage (EUS-GBD), Conservative management (CM) - Cholecystectomy, Gallbladder | Not applicable | Not yet recruiting | Hospital Mutua de Terrassa | 110 | 2026-07-01 | 2026-06-22 |
| Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Placebo (blinded), Vancomycin (blinded), Vancomycin (open-label extension) - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Recruiting | McMaster University | 14 | 2026-06-17 | 2026-10-09 |
| The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching Upadacitinib 15 MG - Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | RenJi Hospital | 44 | 2026-06-01 | 2026-07-01 |
| A Study to Assess How Well and Safely Elafibranor Works in Adult Participants With Primary Sclerosing Cholangitis Elafibranor, Placebo - Primary Sclerosing Cholangitis | Phase 3 | Recruiting | Ipsen | 350 | 2026-05-14 | 2026-10-23 |
| Fecal Microbiota Transplantation for Primary Sclerosing Cholangitis - Randomized Study Versus Sham Transplantation Fecal microbiota transplantation (FMT), Sham-transplantation (placebo) - Primary Sclerosing Cholangitis (PSC), Inflammatory Bowel Disease (IBD) | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 72 | 2026-05-01 | 2026-03-17 |
| Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Injection of 37℃ contrast agent - Cholangitis | Not applicable | Not yet recruiting | Hepatopancreatobiliary Surgery Institute of Gansu Province | 100 | 2026-04-01 | 2025-12-26 |
| Biodegradable Stents in Primary Sclerosing Cholangitis archimedes stent - Primary Sclerosing Cholangitis (PSC) | Not applicable | Recruiting | King's College Hospital NHS Trust | 20 | 2026-03-01 | 2026-05-29 |
| Biochemical Response and Clinical Outcomes in Patients With PBC Only observation - Primary Biliary Cholangitis (PBC), Primary Biliary Cholangitis | Recruiting | RenJi Hospital | 3000 | 2026-02-01 | 2026-03-04 | |
| Sedation Methods in Percutaneous Transhepatic Biliary Drainage: Procedure Quality and Recovery Remifentanil, Ketamine - Fragility, Biliary Obstruction | Not applicable | Recruiting | Ankara City Hospital Bilkent | 98 | 2026-02-01 | 2026-11-12 |
| A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC) TAK-781, Placebo - Healthy Volunteers, Primary Sclerosing Cholangitis | Phase 1 | Recruiting | Takeda | 134 | 2026-01-07 | 2026-03-05 |
| A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSC LB-P8 low-dose, LB-P8 high-dose, Placebo - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Recruiting | LISCure Biosciences | 87 | 2025-11-01 | 2025-10-24 |
| Cholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Cholangitis Post Kasai in Biliary Atresia) Biliary Atresia, Kasai Portoenterostomy Status, Cholangitis | Not yet recruiting | University Hospital, Geneva | 40 | 2025-10-01 | 2025-08-19 | |
| Efficacy and Safety of HK-660S in the Treatment of Primary Sclerosing Cholangitis HK-660S 100mg, HK-660S 200mg, Placebo - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | CuromeBiosciences | 105 | 2025-08-18 | 2025-05-16 |
| A Study Evaluating the Safety, Tolerability, and Efficacy of Aramchol Meglumine in Primary Sclerosing Cholangitis Aramchol meglumine - Primary Sclerosing Cholangitis | Phase 2 | Withdrawn | Galmed Pharmaceuticals Ltd | 2025-06-01 | 2025-06-12 | |
| Prospective Cohort of Immune Checkpoint Inhibitor-induced Hepatitis Blood samples - Liver Injury, Secondary to Immune Checkpoint Inhibitors | Recruiting | University Hospital, Montpellier | 250 | 2025-04-22 | 2026-06-18 |
Showing 20 of 216. Sign in to see all of them.
Cholangitis, Sclerosing (147) · Liver Cirrhosis, Biliary (27) · Cholangiocarcinoma (17) · Hepatitis, Autoimmune (16) · Inflammatory Bowel Diseases (16) · Cholestasis (14) · Biliary Atresia (12) · Choledocholithiasis (11) · Pancreatitis (10) · Gallstones (9) · Colitis, Ulcerative (8) · Digestive System Diseases (8) · Liver Diseases (8) · Pruritus (8)
Biliary Tract Diseases (210) · Bile Duct Diseases (209) · Digestive System Diseases (208) · Pathological Conditions, Signs and Symptoms (58) · Pathologic Processes (49) · Liver Diseases (38) · Fibrosis (28) · Cholestasis, Intrahepatic (27) · Liver Cirrhosis (26) · Neoplasms (25) · Gastroenteritis (24) · Gastrointestinal Diseases (24) · Intestinal Diseases (23) · Adenocarcinoma (21)
Vancomycin (13) · Ursodeoxycholic Acid (5) · cilofexor (4) · Ceftriaxone (3) · Cholangiopancreatography, Endoscopic Retrograde (3) · Ciprofloxacin (3) · Gentamicins (3) · Ketamine (3) · 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid (2) · Bezafibrate (2) · Blood Specimen Collection (2) · Fecal Microbiota Transplantation (2) · Fenofibrate (2) · Meropenem (2) · Metronidazole (2)
Mayo Clinic (13) · Assistance Publique - Hôpitaux de Paris (8) · Gilead Sciences (7) · Brigham and Women's Hospital (5) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (4) · Hepatopancreatobiliary Surgery Institute of Gansu Province (4) · HighTide Therapeutics (Hong Kong) Limited (4) · Mirum Pharmaceuticals, Inc. (4) · Stanford University (4) · Children's Hospital Medical Center, Cincinnati (3) · Dr. Falk Pharma GmbH (3) · Karolinska University Hospital (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · Perspectum (3) · RenJi Hospital (3)
United States (82) · United Kingdom (24) · France (22) · China (21) · Canada (20) · Germany (17) · Italy (16) · Netherlands (15) · Spain (14) · Belgium (11) · South Korea (11) · Sweden (9) · Israel (8) · Austria (7) · Switzerland (7)
Alexander Miethke, MD (2) · Azlanudin Azman (2) · Elizabeth Carey, MD (2) · Joshua Korzenik, MD (2) · Joshua R Korzenik, MD (2) · Li Yang, MD (2) · Michael Trauner, MD (2) · Michel Kahaleh, MD (2) · Xiong Ma, MD, PhD (2) · Xun Li, M.D., Ph. D. (2) · Abeer Sharaf, AP (1)
PMID 23054338, PMID 32633158, PMID 41804276, PMID 10526025, PMID 10655252, PMID 12145577, PMID 15067627, PMID 15557948, PMID 15933689, PMID 16185975, PMID 17252293, PMID 17252297, PMID 17509029, PMID 17696583, PMID 18061594, PMID 18462108, PMID 19238021, PMID 19249039, PMID 19286178, PMID 19585548, PMID 19792866, PMID 20083751, PMID 20135172, PMID 20927758, PMID 21134112, PMID 21295641, PMID 21692712, PMID 21791473, PMID 21835401, PMID 21885599, PMID 2209498, PMID 23081843, PMID 23307001, PMID 23307003, PMID 23384404, PMID 23612857, PMID 23871320, PMID 23997958, PMID 24162138, PMID 24206748, PMID 24338858, PMID 24493296, PMID 24914504, PMID 25005650, PMID 25399287, PMID 25442089, PMID 25446490, PMID 25451659, PMID 25534776, PMID 25616752
2014 (4), 2019 (2), 2023 (2), 2015 (1), 2016 (1), 2018 (1), 2025 (1), R01DK056924 (1), R03DK052344 (1), R03DK071851 (1), RC2DK118619 (1), U24DK062456 (1)