23 completed, 9 terminated, 8 recruiting, 6 not yet recruiting. 57 Phase 2, 5 Phase 1, 4 Phase 3.
Follow Cholangitis: new trials by email Literature Review of Cholangitis trials Research Report on Cholangitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FEAST and HOPE: Redox PSC Pilot Study N-Acetyl Cysteine (NAC), Alpha-Lipoic Acid (ALA), Nicotinamide Riboside (NR) - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 15 | 2027-01-01 | 2026-10-27 |
| Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Nemolizumab-ilto - Chronic Hepatic Pruritus, Cholestatic Liver Disease | Phase 2 | Not yet recruiting | Mayo Clinic | 15 | 2026-11-01 | 2026-09-28 |
| Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis Oral Vancomycin - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Tampere University Hospital | 140 | 2026-10-01 | 2026-09-10 |
| Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Placebo (blinded), Vancomycin (blinded), Vancomycin (open-label extension) - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Recruiting | McMaster University | 14 | 2026-06-17 | 2026-10-09 |
| The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching Upadacitinib 15 MG - Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | RenJi Hospital | 44 | 2026-06-01 | 2026-07-01 |
| Fecal Microbiota Transplantation for Primary Sclerosing Cholangitis - Randomized Study Versus Sham Transplantation Fecal microbiota transplantation (FMT), Sham-transplantation (placebo) - Primary Sclerosing Cholangitis (PSC), Inflammatory Bowel Disease (IBD) | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 72 | 2026-05-01 | 2026-03-17 |
| A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSC LB-P8 low-dose, LB-P8 high-dose, Placebo - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Recruiting | LISCure Biosciences | 87 | 2025-11-01 | 2025-10-24 |
| Efficacy and Safety of HK-660S in the Treatment of Primary Sclerosing Cholangitis HK-660S 100mg, HK-660S 200mg, Placebo - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | CuromeBiosciences | 105 | 2025-08-18 | 2025-05-16 |
| A Study Evaluating the Safety, Tolerability, and Efficacy of Aramchol Meglumine in Primary Sclerosing Cholangitis Aramchol meglumine - Primary Sclerosing Cholangitis | Phase 2 | Withdrawn | Galmed Pharmaceuticals Ltd | 2025-06-01 | 2025-06-12 | |
| Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation Fenofibrate (drug), Blood draw for the laboratory assessment, MRI using a hepatobiliary phase contrast agent (Gd-EOB-DPTA) - Primary Sclerosing Cholangitis, Liver Transplant, Complications | Phase 2 | Recruiting | Mayo Clinic | 80 | 2025-04-15 | 2026-07-17 |
| A Multi-center Evaluation of Aldafermin in a Randomized, Double-blind, Placebo-controlled Study in Subjects With Primary Sclerosing Cholangitis. aldafermin, Placebo - Primary Sclerosing Cholangitis | Phase 2 / Phase 3 | Withdrawn | NGM Biopharmaceuticals, Inc | 2024-10-21 | 2025-05-07 | |
| Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis Gentamicin - single dose, Distilled water - Acute Cholangitis, Biliary Tract Infection | Phase 2 | Recruiting | National University of Malaysia | 172 | 2024-07-09 | 2026-02-12 |
| The Effects of Bromelain Supplement in Patients With Ulcerative Colitis Bromlein, Placebo - Ulcerative Colitis, Primary Sclerosing Cholangitis | Phase 2 / Phase 3 | Completed | National Nutrition and Food Technology Institute | 52 | 2024-04-20 | 2026-10-27 |
| FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis Faecal Microbiota Transplant, FMT Placebo - Primary Sclerosing Cholangitis, Inflammatory Bowel Diseases | Phase 2 | Recruiting | University of Birmingham | 58 | 2024-03-27 | 2026-09-24 |
| Detoxification of the Liver In PSC (Dolphin) BRS201, Placebo - Primary Sclerosing Cholangitis | Phase 2 | Recruiting | Brigham and Women's Hospital | 28 | 2023-12-12 | 2026-07-21 |
| CS0159 in Chinese Patients With PSC (Primary Sclerosing Cholangitis) CS0159 - Primary Sclerosing Cholangitis | Phase 2 | Active not recruiting | Cascade Pharmaceuticals, Inc | 50 | 2023-08-07 | 2026-03-13 |
| Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography. Ketamine, Midazolam, Pethidin - Cholangitis, Pancreatic Cancer | Phase 2 | Completed | National University of Malaysia | 90 | 2023-07-18 | 2025-03-25 |
| Vancomycin in Primary Sclerosing Cholangitis in Italy Oral Vancomycin, Placebo - Primary Sclerosing Cholangitis, Liver and Intrahepatic Bile Duct Disorder | Phase 2 | Recruiting | University of Milano Bicocca | 84 | 2023-06-15 | 2025-07-25 |
| Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis. Hymecromone - Primary Sclerosing Cholangitis | Phase 2 | Recruiting | Aparna Goel | 24 | 2023-05-10 | 2025-06-13 |
| Safety and Tolerability of A3907 in Primary Sclerosing Cholangitis Ritivixibat - Primary Sclerosing Cholangitis | Phase 2 | Terminated | Albireo, an Ipsen Company | 18 | 2023-01-09 | 2026-05-04 |
Showing 20 of 57. Sign in to see all of them.
Cholangitis, Sclerosing (51) · Cholestasis (5) · Digestive System Diseases (5) · Liver Cirrhosis, Biliary (5) · Pruritus (5) · Biliary Tract Diseases (4) · Colitis, Ulcerative (4) · Inflammatory Bowel Diseases (4) · Bile Duct Diseases (3) · Choledocholithiasis (2) · Hepatitis, Autoimmune (2) · Liver Diseases (2) · Aortic Arch Syndromes (1) · Arthritis, Rheumatoid (1)
Bile Duct Diseases (54) · Biliary Tract Diseases (53) · Digestive System Diseases (52) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (9) · Gastroenteritis (8) · Gastrointestinal Diseases (8) · Intestinal Diseases (8) · Fibrosis (6) · Liver Diseases (6) · Signs and Symptoms (6) · Skin Diseases (6) · Skin Manifestations (6) · Skin and Connective Tissue Diseases (6)
Vancomycin (4) · Fecal Microbiota Transplantation (2) · Fenofibrate (2) · Ketamine (2) · Ursodeoxycholic Acid (2) · aldafermin (2) · volixibat (2) · (2-methyl-4-(5-methyl-2-(4-trifluoromethyl-phenyl)-2H-(1,2,3)triazol-4-ylmethylsulfanyl)phenoxy)acetic acid (1) · 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid (1) · Acetylcysteine (1) · Blood Specimen Collection (1) · Ceftriaxone (1) · Cladribine (1) · Curcumin (1) · Gentamicins (1)
Brigham and Women's Hospital (4) · Mayo Clinic (4) · Gilead Sciences (3) · HighTide Therapeutics (Hong Kong) Limited (3) · Mirum Pharmaceuticals, Inc. (3) · University of Birmingham (3) · Assistance Publique - Hôpitaux de Paris (2) · CuromeBiosciences (2) · Elizabeth Carey (2) · NGM Biopharmaceuticals, Inc (2) · National University of Malaysia (2) · Albireo, an Ipsen Company (1) · Aparna Goel (1) · Assiut University (1) · Cascade Pharmaceuticals, Inc (1)
United States (32) · United Kingdom (13) · Canada (12) · France (8) · Germany (7) · Italy (7) · Spain (7) · Netherlands (6) · Belgium (5) · Israel (4) · Austria (3) · China (3) · Argentina (2) · Australia (2) · Brazil (2)
Azlanudin Azman (2) · Elizabeth Carey, MD (2) · Joshua R Korzenik, MD (2) · Adrian Di Bisceglie, MD,FACP,FAASLD (1) · Adrian DiBisceglie, MD (1) · Alastair Smith, MD (1) · Aparna Goel, MD (1) · Arun Sanyal, MD (1) · Azita Hekmatdoost, MD, PhD (1) · Channa Jayasekera (1) · Cynthia Levy, MD (1) · Do-hyun Park (1) · George Harb, MD (1)
PMID 17252293, PMID 17252297, PMID 19585548, PMID 23997958, PMID 25674457, PMID 26988206, PMID 28337833, PMID 28529147, PMID 28674140, PMID 28941329, PMID 30153359, PMID 30472651, PMID 30661255, PMID 32165251, PMID 33681680, PMID 33898959, PMID 36327436, PMID 37055910, PMID 37184523, PMID 38967589, PMID 39762111, PMID 39996122, PMID 40350321, PMID 40439725, PMID 4083861, PMID 41016442, PMID 41387825, PMID 41513411, PMID 42489629
2014 (3), 2023 (2), 2015 (1), 2016 (1), 2019 (1), 2025 (1), R01DK056924 (1)