9 completed, 5 terminated, 4 active not recruiting, 3 withdrawn. 15 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3, 1 Phase 4.
Follow Cervical Degenerative Disc Disease: new trials by email Literature Review of Cervical Degenerative Disc Disease trials Research Report on Cervical Degenerative Disc Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Screw-Integrated vs Traditional Cervical Cages in ACDF for Degenerative Disc Disease cervical cage with integrated screws, traditional standalone cervical cage - Cervical Cage With Screw, Cervical Degenerative Disc Disease | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-03-15 | 2026-02-24 |
| Minimally Invasive Posterior Decompression of the Cervical Spine minimally invasive decompression via the posterior approach - Cervical Degenerative Disc Disease, Cervical Stenosis | Not applicable | Active not recruiting | N.N. Priorov National Medical Research Center of Traumatology and Orthopedics | 30 | 2025-05-19 | 2026-07-06 |
| Post-Market Data Collection to Evaluate the Performance of the Synergy Disc® Synergy cervical spine disc replacement - Cervical Degenerative Disc Disease | Recruiting | Synergy Spine Solutions | 50 | 2025-03-17 | 2026-05-01 | |
| Multi-Centre Post-Market Data Collection Synergy cervical disc system - Cervical Degenerative Disc Disease | Withdrawn | Synergy Spine Solutions | 2024-09-25 | 2025-06-17 | ||
| Real World Data Collection on the Synergy Disc Synergy Cervical Disc system - Cervical Degenerative Disc Disease | Recruiting | Synergy Spine Solutions | 50 | 2024-08-06 | 2026-01-09 | |
| Post Market Data Collection Protocol to Evaluate the Performance of the Synergy Disc Synergy cervical disc system - Cervical Degenerative Disc Disease | Withdrawn | Synergy Spine Solutions | 2024-04-15 | 2026-05-07 | ||
| The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery Anterior Cervical Discectomy and Fusion - Cervical Degenerative Disc Disease | Not applicable | Active not recruiting | Synergy Spine Solutions | 200 | 2023-06-01 | 2026-07-06 |
| Dynamic Cervical Implant (DCI) Versus Anterior Cervical Discectomy And Fusion(ACDF) For The Treatment Of Single-Level Cervical Degenerative Disc Disease (DDD): An RCT Cervical spine surgery - Cervical Degenerative Disc Disease | Not applicable | Unknown | Assiut University | 50 | 2022-08-25 | 2022-08-30 |
| The Synergy Disc To Anterior Cervical Discectomy and Fusion Anterior Cervical Discectomy & Fusion - Cervical Degenerative Disc Disease | Not applicable | Active not recruiting | Synergy Spine Solutions | 175 | 2020-10-30 | 2025-11-19 |
| M6-C Post Approval Study (PAS) standard radiographic imaging, cervical total disc replacement - Cervical Degenerative Disc Disease, Cervical Radiculopathy | Active not recruiting | Spinal Kinetics | 152 | 2019-11-30 | 2025-07-30 | |
| An Investigation of the Metal Concentration in Patients Implanted With the PRESTIGE LP™ Cervical Disc at Two Contiguous Levels in the Cervical Spine PRESTIGE LP™ Cervical Disc - Cervical Degenerative Disc Disease, Radiculopathy | Not applicable | Terminated | Medtronic Spinal and Biologics | 25 | 2018-06-06 | 2024-04-05 |
| Total Disc Replacement Versus Anterior Cervical Decompression and Fusion Surgical treatment of cervical degenerative disc disease (CP ESP®), Surgical treatment of cervical degenerative disc disease (Axelle®) - Cervical Degenerative Disc Disease | Not applicable | Completed | University Hospital, Bordeaux | 79 | 2015-11-04 | 2022-01-03 |
| Investigation of the Simplify® Cervical Artificial Disc Simplify Disc, Anterior Cervical Discectomy & Fusion - Cervical Degenerative Disc Disease | Not applicable | Completed | NuVasive | 150 | 2015-11-01 | 2026-01-08 |
| Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion Methylprednisolone Acetate, Hemostatic Matrix Kit - Cervical Disc Herniation, Cervical Degenerative Disc Disease | Not applicable | Completed | Hospital for Special Surgery, New York | 128 | 2015-08-01 | 2023-07-10 |
| Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease DTRAX Graft - Cervical Spondylosis, Cervical Radiculopathy | Not applicable | Withdrawn | Providence Medical Technology, Inc. | 2012-05-01 | 2020-03-04 | |
| PureGen: Radiographic Analysis of Fusion for ACDF PureGen Osteoprogenitor Cell Allograft - Cervical Degenerative Disc Disease | Terminated | Alphatec Spine, Inc. | 30 | 2011-02-01 | 2022-03-03 | |
| Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion NeoFuse, MasterGraft Granules - Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 12 | 2010-06-01 | 2020-06-29 |
| Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy NeoFuse, Allograft - Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 2 | Completed | Mesoblast, Ltd. | 24 | 2010-06-01 | 2019-08-16 |
| Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease DISCOVER™ Artificial Cervical Disc, ACDF - Cervical Degenerative Disc Disease | Phase 4 | Terminated | DePuy International | 60 | 2008-05-01 | 2015-09-21 |
| Advent™ Cervical Disc Versus ACDF for Treatment of One Level Degenerative Disc Disease (IDE Study) Cervical Artificial Disc (Advent™ Cervical Disc), Hallmark™ Anterior Cervical Plate System - Cervical Degenerative Disc Disease | Not applicable | Terminated | Orthofix Inc. | 108 | 2008-03-01 | 2014-03-27 |
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Radiculopathy (7) · Spinal Cord Diseases (5) · Intervertebral Disc Degeneration (2) · Spinal Stenosis (2) · Ankylosis (1) · Deglutition Disorders (1) · Kyphosis (1) · Spondylosis (1)
Nervous System Diseases (7) · Neuromuscular Diseases (7) · Peripheral Nervous System Diseases (7) · Bone Diseases (5) · Central Nervous System Diseases (5) · Musculoskeletal Diseases (5) · Spinal Diseases (5) · Digestive System Diseases (1) · Esophageal Diseases (1) · Gastrointestinal Diseases (1) · Joint Diseases (1) · Otorhinolaryngologic Diseases (1) · Pharyngeal Diseases (1) · Spinal Curvatures (1)
Bone Plates (3) · Gene Fusion (2) · Total Disc Replacement (2) · Transplantation, Homologous (2) · Arthrodesis (1) · Arthroplasty (1) · Methylprednisolone Acetate (1)
Synergy Spine Solutions (6) · Medtronic Spinal and Biologics (4) · Assiut University (2) · Mesoblast, Ltd. (2) · Alphatec Spine, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · DePuy International (1) · DePuy Spine (1) · Hospital for Special Surgery, New York (1) · N.N. Priorov National Medical Research Center of Traumatology and Orthopedics (1) · NuVasive (1) · Orthofix Inc. (1) · Providence Medical Technology, Inc. (1) · Spinal Kinetics (1) · University Hospital, Bordeaux (1)
United States (13) · Australia (3) · United Kingdom (3) · France (2) · Germany (2) · Netherlands (2) · Ireland (1) · Italy (1) · Malaysia (1) · Russia (1) · Spain (1)
Roger Brown (2) · Bita P. Ghadimi (1) · Brian Andrews, M.D. (1) · Bruce McCormack, M.D. (1) · Jane M Jacob, PhD (1) · John K Burkus, M.D. (1) · Josh Butters, ME, MBA (1) · Kyle Malone (1) · Mohamed Abdel-Hay El-Meshtawy (1) · Philippe Cottin, MD (1) · Rick C Sasso, MD (1) · Robyn Capobianco, PhD (1)
PMID 31970051, PMID 27129045, PMID 27441182, PMID 28304237, PMID 28387616, PMID 31075769, PMID 31226684, PMID 32049677