20 completed, 19 recruiting, 3 active not recruiting, 3 terminated. 15 Not applicable, 6 Phase 2, 3 Phase 1, 1 Early Phase 1, 1 Phase 3.
Follow Spastic Paraplegia, Hereditary: new trials by email Literature Review of Spastic Paraplegia, Hereditary trials Research Report on Spastic Paraplegia, Hereditary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-09-30 | 2026-10-23 | |
| Neuromodulation to Enhance Motor Function in HSP transcutaneous spinal cord stimulation - Hereditary Spastic Paraplegia | Not applicable | Recruiting | Rahul Sachdeva | 15 | 2026-04-09 | 2026-04-22 |
| Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease Whole-body Electrical Muscle Stimulation Exercise - Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | University of Missouri-Columbia | 50 | 2026-03-10 | 2026-03-17 |
| Dental-Oral and Craniofacial Characteristics of Hereditary Spastic Paraplegia: A Preliminary Study Hereditary Spastic Paraplegia | Completed | University of Barcelona | 50 | 2025-10-15 | 2026-09-02 | |
| Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) BFB-101 (AAV9-CBh-AP4B1) - HSP, Hereditary Spastic Paraplegia | Phase 1 / Phase 2 | Not yet recruiting | BlackfinBio Ltd | 5 | 2025-08-01 | 2025-04-28 |
| A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP Hereditary Spastic Paraplegia | Recruiting | Shanghai 6th People's Hospital | 100 | 2025-03-01 | 2025-04-20 | |
| A Prospective Cohort Study of ITB Treatment for HSP Hereditary Spastic Paraplegia | Recruiting | Shanghai 6th People's Hospital | 50 | 2025-01-01 | 2025-02-26 | |
| Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia Flexibility, Resistance, Aerobic, Movement Execution training - Hereditary Spastic Paraplegia | Not applicable | Recruiting | IRCCS Eugenio Medea | 20 | 2024-12-23 | 2025-01-30 |
| Enhancement of Quality of Work And Life Preventive Participatory workplace intervention - Parkinson Disease, Hereditary Spastic Paraparesis | Not applicable | Active not recruiting | Radboud University Medical Center | 124 | 2024-10-08 | 2026-08-14 |
| TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias Hereditary Spastic Paraplegia, Spastic Ataxia | Recruiting | Heidelberg University | 4000 | 2024-07-16 | 2026-09-01 | |
| D-Cycloserine for Serine Palmitoyltransferase Inhibition D-cycloserine - Hereditary Spastic Paraplegia | Phase 4 | Completed | Massachusetts General Hospital | 1 | 2024-07-10 | 2026-04-21 |
| Calcium Folinate Treatment of Spastic Paraplegia 56 calcium folinate - Hereditary Spastic Paraplegia | Early Phase 1 | Recruiting | Shanghai 6th People's Hospital | 10 | 2024-07-01 | 2024-06-27 |
| Spastic Paraplegia - Centers of Excellence Research Network Hereditary Spastic Paraplegia, Primary Lateral Sclerosis | Recruiting | Boston Children's Hospital | 100 | 2024-06-04 | 2026-03-18 | |
| 12-Week Strength and Functional Exercise Program for Hereditary Spastic Paraplegia Trial (HSPMOVE) Individualized Functional and Strength Exercises - Hereditary Spastic Paraplegia | Not applicable | Enrolling by invitation | Hospital de Clinicas de Porto Alegre | 20 | 2024-04-27 | 2026-05-01 |
| Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast intensive reeducation - Hereditary Spastic Paraparesis | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2024-04-04 | 2024-11-25 |
| Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology Syde, Dynamometric measurements of muscle strength, The 6-minute walk test (6MWT) - Neuromuscular Diseases, Obesity (Disorder) | Not applicable | Recruiting | Centre Hospitalier Universitaire de Liege | 300 | 2024-03-29 | 2025-08-22 |
| STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies Hereditary Spastic Paraplegia | Recruiting | IRCCS Fondazione Stella Maris | 500 | 2024-01-24 | 2026-03-27 | |
| Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals MTR-601 - Muscle Spasticity, Hypertonia, Muscle | Phase 1 | Completed | Motric Bio | 89 | 2023-09-11 | 2026-06-05 |
| Natural History Study of Patients with HPDL Mutations Patient Registry, Dry blood spots sampling - Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia | Recruiting | University of California, San Diego | 50 | 2023-05-18 | 2025-03-30 | |
| The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendoachilles (TA) lengthening or gastrocnemius (GN) recession - Idiopathic Toe Walking, Cerebral Palsy | Not applicable | Recruiting | University of Alberta | 42 | 2023-03-13 | 2026-03-12 |
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Motor Neuron Disease (9) · Amyotrophic Lateral Sclerosis (6) · Muscle Spasticity (6) · Paraplegia (6) · Neuromuscular Diseases (5) · Muscular Atrophy, Spinal (4) · Adrenoleukodystrophy (3) · Cerebral Palsy (3) · Charcot-Marie-Tooth Disease (3) · Leukoencephalopathies (3) · Spastic paraplegia 3, autosomal dominant (3) · Adrenal Insufficiency (2) · Brain Diseases, Metabolic (2) · Brain Diseases, Metabolic, Inborn (2)
Congenital Abnormalities (49) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (49) · Hereditary Sensory and Motor Neuropathy (49) · Nervous System Malformations (49) · Peripheral Nervous System Diseases (49) · Polyneuropathies (49) · Nervous System Diseases (48) · Genetic Diseases, Inborn (47) · Heredodegenerative Disorders, Nervous System (47) · Neurodegenerative Diseases (47) · Neuromuscular Diseases (44) · Central Nervous System Diseases (19) · Neurologic Manifestations (16) · Pathological Conditions, Signs and Symptoms (16) · Brain Diseases (14)
Physical Therapy Modalities (2) · 4-Aminopyridine (1) · Atorvastatin (1) · Blood Specimen Collection (1) · Chenodeoxycholic Acid (1) · Cycloserine (1) · Extracorporeal Shockwave Therapy (1) · Leucovorin (1) · Pliability (1) · Resveratrol (1) · Spinal Cord Stimulation (1) · Spinal Puncture (1) · Walk Test (1) · miglustat (1)
IRCCS Eugenio Medea (4) · Assistance Publique - Hôpitaux de Paris (3) · Boston Children's Hospital (3) · IRCCS Fondazione Stella Maris (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Shanghai 6th People's Hospital (3) · University Hospital Tuebingen (3) · Massachusetts General Hospital (2) · Radboud University Medical Center (2) · SwanBio Therapeutics, Inc. (2) · University of Miami (2) · BlackfinBio Ltd (1) · Centre Hospitalier Universitaire de Liege (1) · Dr. Rebecca Schule (1) · European University of Lefke (1)
United States (17) · Italy (9) · Germany (7) · China (5) · France (5) · Netherlands (5) · Austria (2) · Brazil (2) · Canada (2) · Poland (2) · South Africa (2) · Spain (2) · Belgium (1) · Cyprus (1) · Czechia (1)
Filippo M Santorelli, MD PhD (2) · Li Cao, phD (2) · Michael Benatar, MD, PhD (2) · Alan Hand, MD (1) · Callyn Kirk, MSPH (1) · Craig D Blackstone, M.D. (1) · Darius Ebrahimi-Fakhari, MD, PhD (1) · Elbrich Postma, PhD (1) · Ferda Selcuk (1) · Filippo M Santorelli, Dr. (1) · Jakub M Antczak, MD (1) · James D. Berry, MD, MPH (1)
PMID 41491634, PMID 10540002, PMID 17030772, PMID 17364435, PMID 17709710, PMID 17980667, PMID 19833552, PMID 19922132, PMID 21706151, PMID 22507681, PMID 23421600, PMID 23944684, PMID 23952636, PMID 24067398, PMID 24070404, PMID 24778202, PMID 25054277, PMID 26205535, PMID 29228183, PMID 31214256, PMID 31646384, PMID 32139654, PMID 33101180, PMID 33413555, PMID 35472722, PMID 37804674, PMID 38058356, PMID 38291924, PMID 38557877, PMID 39185513, PMID 39270623, PMID 40040914, PMID 40368591, PMID 4056836, PMID 41199121, PMID 41667181, PMID 8229050, PMID 8302340, PMID 8423829, PMID 8639063, PMID 8858057
U54NS092091 (2), 2019 (1), 5RC1NS068179-02 (1), R01NS072248 (1), T32GM007748 (1), U01TR001263 (1)