37 unknown, 32 completed, 19 recruiting, 10 active not recruiting. 48 Phase 2, 29 Phase 3, 14 Not applicable, 8 Phase 1, 3 Early Phase 1.
Follow Hyperthermic Intraperitoneal Chemotherapy: new trials by email Literature Review of Hyperthermic Intraperitoneal Chemotherapy trials Research Report on Hyperthermic Intraperitoneal Chemotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HIPEC Priming Followed by Serplulimab Plus SOX/XELOX in Locally Advanced Gastric Cancer Hyperthermic Intraperitoneal Chemotherapy, Serplulimab, S-1 - Locally Advanced Gastric Cancer, Gastric Adenocarcinoma | Phase 2 | Recruiting | Shanghai Changzheng Hospital | 48 | 2026-07-13 | 2026-10-22 |
| To Evaluate the Feasibility and Safety of Combining Surgery (Pancreatectomy and Cytoreduction) With HIPEC for Treating Pancreatic Cancer With Peritoneal Involvement. Pancreatectomy, Complete Cytoreduction, Hyperthermic Intraperitoneal Chemotherapy (HIPEC) - Pancreatic Adenocarcinoma, Peritoneal (Metastatic) Cancer | Not applicable | Recruiting | Unidade Local de Saúde São João, Oporto | 20 | 2026-03-01 | 2026-03-25 |
| Heated Versus Aerosol-based Laparoscopic Chemotherapy for Cancer That Has Spread to the Peritoneum (Abdominal Lining) Heated intra-peritoneal chemotherapy, Aerosolized intra-peritoneal chemotherapy - Peritoneal (Metastatic) Cancer, Peritoneal Carcinomatosis | Phase 2 | Recruiting | Patrick Wagner, MD, FACS | 200 | 2026-01-05 | 2026-02-27 |
| A Prospective, Phase II Clinical Study of HIPEC Combined With NIPS and Tislelizumab Conversion Therapy for Gastric Cancer With Peritoneal Metastasis With Positive Cytology Alone or PCI Score ≤10 HIPEC, NIPS, Paclitaxel Injection, S-1, tislelizumab - Gastric Cancer Peritoneal Metastases | Phase 2 | Not yet recruiting | Hebei Medical University | 30 | 2025-12-12 | 2025-12-26 |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Paclitaxel for Gastric Cancer at High Risk of Peritoneal Recurrence Biopsy Procedure, Biospecimen Collection, Cisplatin - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Enrolling by invitation | Mayo Clinic | 16 | 2025-12-03 | 2026-07-01 |
| Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer curative-intent surgery + HIPEC - Gastric Cancer (GC), HIPEC | Recruiting | Ukrainian Society of Clinical Oncology | 200 | 2025-12-01 | 2026-01-13 | |
| INTERACT Stomach-II intraperitoneal chemotherapy - Peritoneal Metastases From Gastric Cancer | Phase 2 | Recruiting | Erasmus Medical Center | 55 | 2025-10-01 | 2026-10-21 |
| Effects of HIPEC on Postoperative Bowel Motility and Complications Hyperthermic Intraperitoneal Chemotherapy (HIPEC) - HIPEC, Gastro Intestinal Cancer | Active not recruiting | Peking University People's Hospital | 193 | 2025-04-20 | 2026-01-20 | |
| The Safety and Effectiveness of Hyperthermic Intraperitoneal Chemotherapy Combined With Intravenous Chemotherapy for Peritoneal Metastatic Pancreatic Cancer, a Phase II Clinical Trial Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with Cisplatin + Systemic AG Chemotherapy - Hyperthermic Intraperitoneal Chemotherapy, Peritoneal Metastatic Pancreatic Cancer | Phase 2 | Recruiting | Shanghai Zhongshan Hospital | 90 | 2025-04-03 | 2025-04-27 |
| A Clinical Study Evaluating the Efficacy of Systemic Chemotherapy and Immune Checkpoint Inhibitors Combined With Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer Patients With Peritoneal Metastasis HIPEC, SOX, Immune Checkpoint Inhibitors - Gastric Cancer | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 34 | 2025-02-15 | 2025-04-11 |
| Study to Evaluate the Non-inferiority of Low-dose HIPEC Versus High-dose HIPEC in the Treatment of PMP (HIPEC-PMP) Mitomycin c - Pseudomyxoma Peritonei | Phase 3 | Recruiting | University of Southampton | 176 | 2024-12-04 | 2026-02-19 |
| A Prospective Cohort Study on the Treatment of Locally Advanced Gastric Cancer Tislelizumab, SOX, HIPEC - Gastric Cancer, Gastroesophageal Junction Cancer | Recruiting | Southwest Hospital, China | 122 | 2024-12-01 | 2025-01-07 | |
| Secondary Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for PARP Inhibitors Resistance Patients Secondary cytoreduction, Hyperthermic intraperitoneal chemotherapy - Ovarian Cancer | Phase 2 | Not yet recruiting | Fudan University | 94 | 2024-08-31 | 2024-08-09 |
| The Efficacy and Safety of HIPEC Combined With PD-1 and SOX Chemotherapy for the Translational Treatment of GC or EGJC With PM HIPEC, Systemic therapy - Gastric Cancer, Metastatic | Phase 2 | Active not recruiting | The First Affiliated Hospital with Nanjing Medical University | 50 | 2024-05-31 | 2025-07-16 |
| Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Nab-paclitaxel - Metastatic Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 2 | Active not recruiting | Mayo Clinic | 40 | 2024-02-15 | 2026-10-15 |
| Intraperitoneal LSTA1 in CRS-HIPEC CRS-HIPEC + LSTA1, CRS-HIPEC alone - Colorectal Cancer, Ovarian Carcinoma | Phase 1 | Withdrawn | University of California, San Diego | 2023-11-30 | 2024-08-20 | |
| Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study Cisplatin, Computed Tomography, Gastrectomy - Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Recruiting | Mayo Clinic | 40 | 2023-04-20 | 2026-04-08 |
| HIPEC Combined Gastrectomy in Patients With Advanced Gastric Cancer Received Neoadjuvant Chemotherapy HIPEC - Gastric Cancer, Peritoneal Metastases | Phase 2 / Phase 3 | Not yet recruiting | Zhixin Cao | 200 | 2023-01-01 | 2022-12-06 |
| Laparoscopic Gastrectomy With D2 Lymphadenectomy Combined With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) or Not Hyperthermic Intraperitoneal Chemotherapy (HIPEC) - Gastric Cancer | Phase 3 | Recruiting | The Affiliated Hospital of Qingdao University | 616 | 2022-11-20 | 2026-03-06 |
| Glycocalyx Monitoring in Major Abdominal Surgery Cytoreduction surgery with Hyperthermic Intraperitoneal Chemotherapy, Cephalic DuodenoPancreatectomy - Major Abdominal Surgery | Completed | University Hospital, Rouen | 78 | 2022-07-05 | 2026-05-22 |
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Stomach Neoplasms (34) · Ovarian Neoplasms (31) · Peritoneal Neoplasms (28) · Colorectal Neoplasms (14) · Fallopian Tube Neoplasms (14) · Carcinoma, Ovarian Epithelial (13) · Appendiceal Neoplasms (7) · Neoplasm Metastasis (5) · Pancreatic Neoplasms (4) · Carcinoma (3) · Neoplasms (3) · Pseudomyxoma Peritonei (3) · Recurrence (3) · Uterine Neoplasms (3) · Colonic Neoplasms (2)
Wuhan University (6) · Affiliated Cancer Hospital & Institute of Guangzhou Medical University (4) · Fudan University (4) · Hospices Civils de Lyon (4) · Mayo Clinic (4) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (3) · Wake Forest University Health Sciences (3) · City of Hope Medical Center (2) · Loma Linda University (2) · M.D. Anderson Cancer Center (2) · National Cancer Center, Korea (2) · Shu-Zhong Cui (2) · University Hospital Tuebingen (2) · Zhejiang Cancer Hospital (2) · A.O. Ospedale Papa Giovanni XXIII (1)
China (41) · United States (28) · France (9) · Germany (7) · Spain (7) · Belgium (5) · Netherlands (4) · South Korea (3) · Switzerland (3) · Austria (2) · Italy (2) · Poland (2) · Singapore (2) · Argentina (1) · Australia (1)
Shuzhong Cui, M.D (2) · Zhongqiu Lin, M.D (2) · Aaron S Mansfield (1) · Andre Roncon Dias, MD, PhD (1) · Andrea Hayes-Jordan, MD (1) · Andrea Jewell, MD (1) · Anna Fagotti, MD, PhD (1) · Armando Sardi, M.D. (1) · Beate Rau, Prof. (1) · Brian Boone, MD (1) · Brian D Badgwell (1) · Cornelius A. Thiels, DO, MBA (1)
PMID 16394300, PMID 16485159, PMID 17708508, PMID 19169758, PMID 21424369, PMID 21448361, PMID 24378877, PMID 24628950, PMID 26669784, PMID 26811651, PMID 26903580, PMID 27633880, PMID 27650694, PMID 28273222, PMID 29263704, PMID 29743140, PMID 30131226, PMID 30473706, PMID 30954352, PMID 31060544, PMID 31069579, PMID 32556731, PMID 32594200, PMID 32667582, PMID 32696309, PMID 32717180, PMID 33198674, PMID 35100917, PMID 35262624, PMID 35549912, PMID 35712968, PMID 36608383, PMID 37596449, PMID 37673112, PMID 37690994, PMID 37906724, PMID 37916797, PMID 39549720, PMID 39760061, PMID 39955184, PMID 40115934, PMID 40953882, PMID 41888710, PMID 42419336
2009 (3), 2015 (2), P30CA033572 (2), 2014 (1), 2016 (1), 2018 (1), 2019 (1), 2025 (1), P30CA012197 (1), U10CA180821 (1)